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Conference Paper: Roles of endothelin-1 in beta-amyloid-induced neurotoxicity in hippocampus: an implication for Alzheimer’s pathology

TitleRoles of endothelin-1 in beta-amyloid-induced neurotoxicity in hippocampus: an implication for Alzheimer’s pathology
Authors
Issue Date2015
PublisherBritish Neuroscience Association. The Poster abstracts' website is located at http://www.bna2015.org/BNA2015-Abstract-Book.pdf
Citation
The 2015 Conference of the British Neuroscience Association (BNA 2015), Edinburgh, UK., 12-15 April 2015. In Abstract Book, 2015, p. 735, abstract no. P3-F-012 How to Cite?
AbstractAlzheimer’s disease (AD) is an incurable neurodegenerative disorder. Abnormal levels of endothelin-1 (ET-1) have been demonstrated in parietal white matter(1), cerebral cortex and vessels of the AD brain(2). Neuronal death and accumulation of beta-amyloid (Aβ) are prominent pathological features of AD. Significant neuronal death is found in Aβ-treated primary neurons and Aβ-overexpressing mouse models(3,4). ET-1 is a known vasoconstrictor and neuro-active peptide. ET-1 induces apoptosis in primary retinal neurons(5). In contrary, ET-receptor (ETR) type B agonist can rescue neurons from Aβ-induced apoptosis(6). These findings suggest ET-1 plays dual roles in neurodegeneration and neuroprotection, respectively. This study aims to investigate the effect of ET-1 on Aβ-induced cell death in hippocampal neurons. Primary hippocampal neurons were pretreated with or without ETR antagonists prior to the treatment of oligomeric form of Aβ1-42, ET-1 or both on 14 DIV. Cell viability was measured by MTT assay. Changes in protein expression in apoptotic and ET-1 signaling pathways were assessed by western-blot analysis. This study shed light on the roles of ET-1 in Aβ1-42-neurotoxicity, building upon which the ET-1 signaling pathway as a potential therapeutic target for AD can be further investigated.
DescriptionThe British Neuroscience Association’s Festival of Neuroscience
Poster F - Nervous System Disorders: abstract no. P3-F-012
Persistent Identifierhttp://hdl.handle.net/10722/210569

 

DC FieldValueLanguage
dc.contributor.authorTam, SW-
dc.contributor.authorChung, SK-
dc.contributor.authorLaw, ACK-
dc.date.accessioned2015-06-18T01:43:44Z-
dc.date.available2015-06-18T01:43:44Z-
dc.date.issued2015-
dc.identifier.citationThe 2015 Conference of the British Neuroscience Association (BNA 2015), Edinburgh, UK., 12-15 April 2015. In Abstract Book, 2015, p. 735, abstract no. P3-F-012-
dc.identifier.urihttp://hdl.handle.net/10722/210569-
dc.descriptionThe British Neuroscience Association’s Festival of Neuroscience-
dc.descriptionPoster F - Nervous System Disorders: abstract no. P3-F-012-
dc.description.abstractAlzheimer’s disease (AD) is an incurable neurodegenerative disorder. Abnormal levels of endothelin-1 (ET-1) have been demonstrated in parietal white matter(1), cerebral cortex and vessels of the AD brain(2). Neuronal death and accumulation of beta-amyloid (Aβ) are prominent pathological features of AD. Significant neuronal death is found in Aβ-treated primary neurons and Aβ-overexpressing mouse models(3,4). ET-1 is a known vasoconstrictor and neuro-active peptide. ET-1 induces apoptosis in primary retinal neurons(5). In contrary, ET-receptor (ETR) type B agonist can rescue neurons from Aβ-induced apoptosis(6). These findings suggest ET-1 plays dual roles in neurodegeneration and neuroprotection, respectively. This study aims to investigate the effect of ET-1 on Aβ-induced cell death in hippocampal neurons. Primary hippocampal neurons were pretreated with or without ETR antagonists prior to the treatment of oligomeric form of Aβ1-42, ET-1 or both on 14 DIV. Cell viability was measured by MTT assay. Changes in protein expression in apoptotic and ET-1 signaling pathways were assessed by western-blot analysis. This study shed light on the roles of ET-1 in Aβ1-42-neurotoxicity, building upon which the ET-1 signaling pathway as a potential therapeutic target for AD can be further investigated.-
dc.languageeng-
dc.publisherBritish Neuroscience Association. The Poster abstracts' website is located at http://www.bna2015.org/BNA2015-Abstract-Book.pdf-
dc.relation.ispartofBritish Neuroscience Association Conference, BNA 2015-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleRoles of endothelin-1 in beta-amyloid-induced neurotoxicity in hippocampus: an implication for Alzheimer’s pathology-
dc.typeConference_Paper-
dc.identifier.emailChung, SK: skchung@hkucc.hku.hk-
dc.identifier.emailLaw, ACK: acklaw@hku.hk-
dc.identifier.authorityChung, SK=rp00381-
dc.identifier.authorityLaw, ACK=rp00262-
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros243605-
dc.identifier.spage735, abstract no. P3-F-012-
dc.identifier.epage735, abstract no. P3-F-012-
dc.publisher.placeUnited Kingdom-

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