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Article: Effects of gender, age, and body mass index on fat contents and apparent diffusion coefficients in healthy parotid glands: An MRI evaluation

TitleEffects of gender, age, and body mass index on fat contents and apparent diffusion coefficients in healthy parotid glands: An MRI evaluation
Authors
KeywordsFat saturation
Parotid ADC measurement
IDEAL fat-water separation
PROPELLER
Parotid fat content
Issue Date2014
Citation
European Radiology, 2014, v. 24, n. 9, p. 2069-2076 How to Cite?
AbstractObjectives: To establish standard apparent diffusion coefficient (ADC) and the fat content as a function of age, gender and body mass index (BMI) in healthy parotid glands, and to address the influences of fat suppression on ADC measurements. Methods: A total of 100 healthy adults (gender and age evenly distributed) were prospectively recruited, with parotid fat content measured from gradient-echo images with fat-water separated using iterative decomposition with echo asymmetry and least squares (IDEAL). The ADCs were estimated using both fat-saturated and non-fat-saturated diffusion-weighted imaging via a periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) technique. Results: Parotid fat content was larger in men than in women by about 10 percentage points (P<0.005), and positively associated with BMI and age for both genders (mostly with P<0.001). ADCs estimated with non-fat-saturated PROPELLER were significantly lower in men than in women (P<0.005), but showed no gender difference if measured using fat-saturated PROPELLER (P=0.840). The negative association between parotid ADC and age/BMI/fat (P<0.001) showed greater regression slopes in non-fat-saturated PROPELLER than in fat-saturated data. Conclusions: Parotid fat content in healthy adults correlates positively with both age and BMI; the correlation with age is gender-dependent. Parotid ADC measurements are strongly influenced by fat saturation. Key Points: • Parotid fat content in healthy adults correlates positively with age and BMI. • The rate of aging-related increase in fat contents is gender-dependent. • Parotid ADC measurements are strongly influenced by fat saturation. © 2014 European Society of Radiology.
Persistent Identifierhttp://hdl.handle.net/10722/210134
ISSN
2015 Impact Factor: 3.64
2015 SCImago Journal Rankings: 2.064

 

DC FieldValueLanguage
dc.contributor.authorChang, Hing Chiu-
dc.contributor.authorJuan, Chun Jung-
dc.contributor.authorChiu, Hui Chu-
dc.contributor.authorCheng, Cheng Chieh-
dc.contributor.authorChiu, Su Chin-
dc.contributor.authorLiu, Yi Jui-
dc.contributor.authorChung, Hsiao Wen-
dc.contributor.authorHsu, Hsian He-
dc.date.accessioned2015-05-22T06:06:44Z-
dc.date.available2015-05-22T06:06:44Z-
dc.date.issued2014-
dc.identifier.citationEuropean Radiology, 2014, v. 24, n. 9, p. 2069-2076-
dc.identifier.issn0938-7994-
dc.identifier.urihttp://hdl.handle.net/10722/210134-
dc.description.abstractObjectives: To establish standard apparent diffusion coefficient (ADC) and the fat content as a function of age, gender and body mass index (BMI) in healthy parotid glands, and to address the influences of fat suppression on ADC measurements. Methods: A total of 100 healthy adults (gender and age evenly distributed) were prospectively recruited, with parotid fat content measured from gradient-echo images with fat-water separated using iterative decomposition with echo asymmetry and least squares (IDEAL). The ADCs were estimated using both fat-saturated and non-fat-saturated diffusion-weighted imaging via a periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) technique. Results: Parotid fat content was larger in men than in women by about 10 percentage points (P<0.005), and positively associated with BMI and age for both genders (mostly with P<0.001). ADCs estimated with non-fat-saturated PROPELLER were significantly lower in men than in women (P<0.005), but showed no gender difference if measured using fat-saturated PROPELLER (P=0.840). The negative association between parotid ADC and age/BMI/fat (P<0.001) showed greater regression slopes in non-fat-saturated PROPELLER than in fat-saturated data. Conclusions: Parotid fat content in healthy adults correlates positively with both age and BMI; the correlation with age is gender-dependent. Parotid ADC measurements are strongly influenced by fat saturation. Key Points: • Parotid fat content in healthy adults correlates positively with age and BMI. • The rate of aging-related increase in fat contents is gender-dependent. • Parotid ADC measurements are strongly influenced by fat saturation. © 2014 European Society of Radiology.-
dc.languageeng-
dc.relation.ispartofEuropean Radiology-
dc.subjectFat saturation-
dc.subjectParotid ADC measurement-
dc.subjectIDEAL fat-water separation-
dc.subjectPROPELLER-
dc.subjectParotid fat content-
dc.titleEffects of gender, age, and body mass index on fat contents and apparent diffusion coefficients in healthy parotid glands: An MRI evaluation-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00330-014-3265-z-
dc.identifier.scopuseid_2-s2.0-84905912917-
dc.identifier.volume24-
dc.identifier.issue9-
dc.identifier.spage2069-
dc.identifier.epage2076-
dc.identifier.eissn1432-1084-

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