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Article: Parotid perfusion in nasopharyngeal carcinoma patients in early-to-intermediate stage after low-dose intensity-modulated radiotherapy: Evaluated by fat-saturated dynamic contrast-enhanced magnetic resonance imaging

TitleParotid perfusion in nasopharyngeal carcinoma patients in early-to-intermediate stage after low-dose intensity-modulated radiotherapy: Evaluated by fat-saturated dynamic contrast-enhanced magnetic resonance imaging
Authors
Issue Date2013
Citation
Magnetic Resonance Imaging, 2013, v. 31, n. 8, p. 1278-1284 How to Cite?
AbstractPurpose: To investigate parotid perfusion in early-to-intermediate stage after parotid-sparing radiation dose using fat-saturated DCE-MRI, and to verify whether the perfusion alteration was related to radiation dose and the PSV. Methods and Materials: Thirty-two parotid glands from 16 consecutive patients with pathologically proven nasopharyngeal carcinoma treated by IMRT were examined. The parotid glands received a radiation dose of 28.9. ±. 3.9. Gy with a PSV of 43.1%. ±. 13.9%. Perfusion parameters were calculated using time-shifted Brix model from fat-saturated DCE-MRI data before (pre-RT) and in early-to-intermediate stage after (post-RT) IMRT. Paired t-test was used to evaluate perfusion changes, while Pearson's correlation test was used to examine perfusion dependency on radiation dose and PSV. For multiple comparisons Bonferroni correction was applied. Results: Successful fat saturation was achieved in 29 of 32 parotid glands. Compared with pre-RT, the post-RT parotid glands showed significantly higher A, peak enhancement, and wash-in slope, plus a lower Kel, suggesting a mixed effect of increased vascular permeability and acinar loss. Linear regression showed that peak enhancement was positively associated with radiation dose in post-RT parotid glands. Kel and slope were negatively associated with PSV, while time-to-peak was positively associated with PSV significantly. Conclusions: Our results suggest that time-shifted Brix model is feasible for quantifying parotid perfusion using DCE-MRI. The perfusion alterations in early-to-intermediate stage after IMRT might be related to a mixed effect of increased vascular permeability and acinar loss with dose and PSV dependencies. © 2013 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/210119
ISSN
2015 Impact Factor: 1.98
2015 SCImago Journal Rankings: 1.139

 

DC FieldValueLanguage
dc.contributor.authorCheng, Cheng Chieh-
dc.contributor.authorChiu, Su Chin-
dc.contributor.authorJen, Yee Min-
dc.contributor.authorChang, Hing Chiu-
dc.contributor.authorChung, Hsiao Wen-
dc.contributor.authorLiu, Yi Jui-
dc.contributor.authorChiu, Hui Chu-
dc.contributor.authorChen, Cheng Yu-
dc.contributor.authorHuang, Guo Shu-
dc.contributor.authorJuan, Chun Jung-
dc.date.accessioned2015-05-22T06:06:41Z-
dc.date.available2015-05-22T06:06:41Z-
dc.date.issued2013-
dc.identifier.citationMagnetic Resonance Imaging, 2013, v. 31, n. 8, p. 1278-1284-
dc.identifier.issn0730-725X-
dc.identifier.urihttp://hdl.handle.net/10722/210119-
dc.description.abstractPurpose: To investigate parotid perfusion in early-to-intermediate stage after parotid-sparing radiation dose using fat-saturated DCE-MRI, and to verify whether the perfusion alteration was related to radiation dose and the PSV. Methods and Materials: Thirty-two parotid glands from 16 consecutive patients with pathologically proven nasopharyngeal carcinoma treated by IMRT were examined. The parotid glands received a radiation dose of 28.9. ±. 3.9. Gy with a PSV of 43.1%. ±. 13.9%. Perfusion parameters were calculated using time-shifted Brix model from fat-saturated DCE-MRI data before (pre-RT) and in early-to-intermediate stage after (post-RT) IMRT. Paired t-test was used to evaluate perfusion changes, while Pearson's correlation test was used to examine perfusion dependency on radiation dose and PSV. For multiple comparisons Bonferroni correction was applied. Results: Successful fat saturation was achieved in 29 of 32 parotid glands. Compared with pre-RT, the post-RT parotid glands showed significantly higher A, peak enhancement, and wash-in slope, plus a lower Kel, suggesting a mixed effect of increased vascular permeability and acinar loss. Linear regression showed that peak enhancement was positively associated with radiation dose in post-RT parotid glands. Kel and slope were negatively associated with PSV, while time-to-peak was positively associated with PSV significantly. Conclusions: Our results suggest that time-shifted Brix model is feasible for quantifying parotid perfusion using DCE-MRI. The perfusion alterations in early-to-intermediate stage after IMRT might be related to a mixed effect of increased vascular permeability and acinar loss with dose and PSV dependencies. © 2013 Elsevier Inc.-
dc.languageeng-
dc.relation.ispartofMagnetic Resonance Imaging-
dc.titleParotid perfusion in nasopharyngeal carcinoma patients in early-to-intermediate stage after low-dose intensity-modulated radiotherapy: Evaluated by fat-saturated dynamic contrast-enhanced magnetic resonance imaging-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.mri.2013.03.018-
dc.identifier.pmid23664679-
dc.identifier.scopuseid_2-s2.0-84883740913-
dc.identifier.volume31-
dc.identifier.issue8-
dc.identifier.spage1278-
dc.identifier.epage1284-
dc.identifier.eissn1873-5894-

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