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Article: A study of pre-antibiotic bacteriology in 125 patients with necrotizing enterocolitis

TitleA study of pre-antibiotic bacteriology in 125 patients with necrotizing enterocolitis
Authors
Issue Date1994
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-APA.html
Citation
Acta Paediatrica, 1994, v. 83 n. suppl. 396, p. 45-48 How to Cite?
AbstractOver a five-year period, 125 newborns with necrotizing enterocolitis (NEC) were managed by us. Their mean birthweight was 1700 g and mean maturity was 32 weeks. Before commencement of antibiotics, routine septic work-up was done in order to define the bacterial spectrum and antibiotic sensitivity. The study includes aerobic and anaerobic cultures of gastric and pharyngeal aspirates, blood cultures, umbilical swabs and culture of umbilical catheter tips in relevant cases. Peritoneal swab results were also analyzed if laparotomy was performed. Positive cultures were present in 45 patients (36%) with 55 positive specimens. Fifteen types of organism were isolated: the commonest was Enterobacter (29%), followed by E. coli (14.5%) and Klebsiella (13%). They were resistant to ampicillin and first-generation cephalosporin. These organisms were usually opportunistic pathogens. Overgrowth of them may be the cause of NEC. Regular review of the antibiotic sensitivity of these organisms allows prompt and appropriate choice of antibiotics. At the same time, antibiotic sensitivity for these organisms was analyzed to guide us in the choice of antibiotic therapy.
Persistent Identifierhttp://hdl.handle.net/10722/210020
ISSN
2015 Impact Factor: 1.647
2015 SCImago Journal Rankings: 0.794

 

DC FieldValueLanguage
dc.contributor.authorChan, KL-
dc.contributor.authorSaing, H-
dc.contributor.authorYung, RWH-
dc.contributor.authorYeung, YP-
dc.contributor.authorTsoi, NS-
dc.date.accessioned2015-05-20T01:32:28Z-
dc.date.available2015-05-20T01:32:28Z-
dc.date.issued1994-
dc.identifier.citationActa Paediatrica, 1994, v. 83 n. suppl. 396, p. 45-48-
dc.identifier.issn0803-5253-
dc.identifier.urihttp://hdl.handle.net/10722/210020-
dc.description.abstractOver a five-year period, 125 newborns with necrotizing enterocolitis (NEC) were managed by us. Their mean birthweight was 1700 g and mean maturity was 32 weeks. Before commencement of antibiotics, routine septic work-up was done in order to define the bacterial spectrum and antibiotic sensitivity. The study includes aerobic and anaerobic cultures of gastric and pharyngeal aspirates, blood cultures, umbilical swabs and culture of umbilical catheter tips in relevant cases. Peritoneal swab results were also analyzed if laparotomy was performed. Positive cultures were present in 45 patients (36%) with 55 positive specimens. Fifteen types of organism were isolated: the commonest was Enterobacter (29%), followed by E. coli (14.5%) and Klebsiella (13%). They were resistant to ampicillin and first-generation cephalosporin. These organisms were usually opportunistic pathogens. Overgrowth of them may be the cause of NEC. Regular review of the antibiotic sensitivity of these organisms allows prompt and appropriate choice of antibiotics. At the same time, antibiotic sensitivity for these organisms was analyzed to guide us in the choice of antibiotic therapy.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-APA.html-
dc.relation.ispartofActa Paediatrica-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article]. Authors are not required to remove preprints posted prior to acceptance of the submitted version. Postprint This is the accepted version of the following article: [full citation], which has been published in final form at [Link to final article]. -
dc.subject.meshAnti-Bacterial Agents - pharmacology - therapeutic use-
dc.subject.meshEnterocolitis, Pseudomembranous - drug therapy - microbiology-
dc.subject.meshGram-Negative Bacteria - drug effects - isolation & purification-
dc.subject.meshInfant, Premature, Diseases - drug therapy - microbiology-
dc.subject.meshKlebsiella - drug effects - isolation & purification-
dc.titleA study of pre-antibiotic bacteriology in 125 patients with necrotizing enterocolitis-
dc.typeArticle-
dc.identifier.emailSaing, H: saing@hkucc.hku.hk-
dc.identifier.doi10.1111/j.1651-2227.1994.tb13242.x-
dc.identifier.pmid8086682-
dc.identifier.hkuros3875-
dc.identifier.volume83-
dc.identifier.issuesuppl. 396-
dc.identifier.spage45-
dc.identifier.epage48-
dc.publisher.placeUnited Kingdom-

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