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Article: Passive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infection

TitlePassive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infection
Authors
Issue Date2015
Citation
Journal of Virology, 2015, v. 89 n. 11, p. 6117-6120 How to Cite?
AbstractMiddle East respiratory syndrome (MERS) is a highly lethal pulmonary infection. Serum from convalescent MERS patients may provide some benefit but is not readily available. In contrast, nearly all camels in the Middle East have been infected with MERS-CoV. Here, we show that sera obtained from MERS-immune camels augment the kinetics of MERS-CoV clearance and reduce the severity of pathological changes in infected lungs, with efficacy proportional to the titer of MERS-CoV-neutralizing serum antibody.
Persistent Identifierhttp://hdl.handle.net/10722/209992

 

DC FieldValueLanguage
dc.contributor.authorZhao, Jen_US
dc.contributor.authorPerera, RAPMen_US
dc.contributor.authorKayali, Gen_US
dc.contributor.authorMeyerholz, Den_US
dc.contributor.authorPerlman, Sen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorSandri-Goldin, RMen_US
dc.date.accessioned2015-05-18T03:39:19Z-
dc.date.available2015-05-18T03:39:19Z-
dc.date.issued2015en_US
dc.identifier.citationJournal of Virology, 2015, v. 89 n. 11, p. 6117-6120en_US
dc.identifier.urihttp://hdl.handle.net/10722/209992-
dc.description.abstractMiddle East respiratory syndrome (MERS) is a highly lethal pulmonary infection. Serum from convalescent MERS patients may provide some benefit but is not readily available. In contrast, nearly all camels in the Middle East have been infected with MERS-CoV. Here, we show that sera obtained from MERS-immune camels augment the kinetics of MERS-CoV clearance and reduce the severity of pathological changes in infected lungs, with efficacy proportional to the titer of MERS-CoV-neutralizing serum antibody.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Virologyen_US
dc.titlePassive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infectionen_US
dc.typeArticleen_US
dc.identifier.emailPerera, RAPM: mahenp@hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.identifier.doi10.1128/JVI.00446-15en_US
dc.identifier.hkuros243343en_US
dc.identifier.volume89en_US
dc.identifier.issue11en_US
dc.identifier.spage6117en_US
dc.identifier.epage6120en_US

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