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Conference Paper: MicroRNA-mediated modulations in hyperactive plasmacytoid dendritic cells in systemic lupus erythematosus

TitleMicroRNA-mediated modulations in hyperactive plasmacytoid dendritic cells in systemic lupus erythematosus
Authors
KeywordsMedical sciences
Allergology and immunology
Issue Date2013
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
Citation
The 2013 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2013™), Honolulu, HI., 3-7 May 2013. In Journal of Immunology, 2013, v. 190 n. 1 meeting abstracts, 51.2, P4072 How to Cite?
AbstractSystemic lupus erythematosus (SLE) patients are typically presented by their increased serum type I interferon (IFN) activities. Plasmacytoid dendritic cells (pDCs), the most potent type I IFN-producing cells, are found to be hyperactive in SLE. Using the New Zealand Black/White F1 lupus mouse model, we sought for the regulatory mechanism of IFN production by pDCs in SLE. Mice with lupus symptoms such as high titers of serum anti-nuclear antibodies and persistent proteinuria were compared with the pre-symptomatic ones. Upon toll-like receptor (TLR) 7 and TLR9 stimulations, the up-regulations of co-stimulatory markers CD40, CD86 and MHC class II were significantly heightened in bone-marrow-derived pDCs from the symptomatic mice. Furthermore, the expression profiles of over 700 microRNA (miRNAs) in pDCs upon TLR7 activation were analyzed by low-density arrays. Among those, miRNA-155 was the most highly induced and its induction was consistently higher in pDCs from the symptomatic mice. It was previously found in human studies that miRNA-155 regulates type I IFN production by pDCs and itself inversely regulated by the autocrine/paracrine IFN dynamics. Current investigations pursue on the correlation between up-regulated miRNA-155 induction and aberrant pDC functions in SLE using miRNA mimics and inhibitors. Together, our study should reveal miRNA-mediated modulations in pDC abnormalities in SLE.
DescriptionThis journal suppl. entitled: Immunology 2013 Meeting Abstracts
Persistent Identifierhttp://hdl.handle.net/10722/209736
ISSN
2015 Impact Factor: 4.985
2015 SCImago Journal Rankings: 3.549

 

DC FieldValueLanguage
dc.contributor.authorYan, S-
dc.contributor.authorTam, RCY-
dc.contributor.authorChan, VSF-
dc.contributor.authorLau, CS-
dc.date.accessioned2015-05-14T04:15:08Z-
dc.date.available2015-05-14T04:15:08Z-
dc.date.issued2013-
dc.identifier.citationThe 2013 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2013™), Honolulu, HI., 3-7 May 2013. In Journal of Immunology, 2013, v. 190 n. 1 meeting abstracts, 51.2, P4072-
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10722/209736-
dc.descriptionThis journal suppl. entitled: Immunology 2013 Meeting Abstracts-
dc.description.abstractSystemic lupus erythematosus (SLE) patients are typically presented by their increased serum type I interferon (IFN) activities. Plasmacytoid dendritic cells (pDCs), the most potent type I IFN-producing cells, are found to be hyperactive in SLE. Using the New Zealand Black/White F1 lupus mouse model, we sought for the regulatory mechanism of IFN production by pDCs in SLE. Mice with lupus symptoms such as high titers of serum anti-nuclear antibodies and persistent proteinuria were compared with the pre-symptomatic ones. Upon toll-like receptor (TLR) 7 and TLR9 stimulations, the up-regulations of co-stimulatory markers CD40, CD86 and MHC class II were significantly heightened in bone-marrow-derived pDCs from the symptomatic mice. Furthermore, the expression profiles of over 700 microRNA (miRNAs) in pDCs upon TLR7 activation were analyzed by low-density arrays. Among those, miRNA-155 was the most highly induced and its induction was consistently higher in pDCs from the symptomatic mice. It was previously found in human studies that miRNA-155 regulates type I IFN production by pDCs and itself inversely regulated by the autocrine/paracrine IFN dynamics. Current investigations pursue on the correlation between up-regulated miRNA-155 induction and aberrant pDC functions in SLE using miRNA mimics and inhibitors. Together, our study should reveal miRNA-mediated modulations in pDC abnormalities in SLE.-
dc.languageeng-
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org-
dc.relation.ispartofJournal of Immunology-
dc.subjectMedical sciences-
dc.subjectAllergology and immunology-
dc.titleMicroRNA-mediated modulations in hyperactive plasmacytoid dendritic cells in systemic lupus erythematosus-
dc.typeConference_Paper-
dc.identifier.emailYan, S: ssyan@hku.hk-
dc.identifier.emailChan, VSF: sfvchan@hku.hk-
dc.identifier.emailLau, CS: cslau@hku.hk-
dc.identifier.authorityChan, VSF=rp01459-
dc.identifier.authorityLau, CS=rp01348-
dc.identifier.volume190-
dc.identifier.issue1, meeting abstracts-
dc.publisher.placeUnited States-

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