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Article: MicroRNA and messenger RNA profiling reveals new biomarkers and mechanisms for RDX induced neurotoxicity

TitleMicroRNA and messenger RNA profiling reveals new biomarkers and mechanisms for RDX induced neurotoxicity
Authors
Issue Date2014
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcgenomics/
Citation
BMC Genomics, 2014, v. 15 n. Suppl 11, p. S1 How to Cite?
AbstractBackground RDX is a well-known pollutant to induce neurotoxicity. MicroRNAs (miRNA) and messenger RNA (mRNA) profiles are useful tools for toxicogenomics studies. It is worthy to integrate MiRNA and mRNA expression data to understand RDX-induced neurotoxicity. Results Rats were treated with or without RDX for 48 h. Both miRNA and mRNA profiles were conducted using brain tissues. Nine miRNAs were significantly regulated by RDX. Of these, 6 and 3 miRNAs were up- and down-regulated respectively. The putative target genes of RDX-regulated miRNAs were highly nervous system function genes and pathways enriched. Fifteen differentially genes altered by RDX from mRNA profiles were the putative targets of regulated miRNAs. The induction of miR-71, miR-27ab, miR-98, and miR-135a expression by RDX, could reduce the expression of the genes POLE4, C5ORF13, SULF1 and ROCK2, and eventually induce neurotoxicity. Over-expression of miR-27ab, or reduction of the expression of unknown miRNAs by RDX, could up-regulate HMGCR expression and contribute to neurotoxicity. RDX regulated immune and inflammation response miRNAs and genes could contribute to RDX- induced neurotoxicity and other toxicities as well as animal defending reaction response to RDX exposure. Conclusions Our results demonstrate that integrating miRNA and mRNA profiles is valuable to indentify novel biomarkers and molecular mechanisms for RDX-induced neurological disorder and neurotoxicity.
Persistent Identifierhttp://hdl.handle.net/10722/209726
ISSN
2015 Impact Factor: 3.867
2015 SCImago Journal Rankings: 2.343

 

DC FieldValueLanguage
dc.contributor.authorDeng, Y-
dc.contributor.authorAi, J-
dc.contributor.authorGuan, X-
dc.contributor.authorWang, Z-
dc.contributor.authorYan, B-
dc.contributor.authorZhang, D-
dc.contributor.authorLiu, C-
dc.contributor.authorWilbanks, MS-
dc.contributor.authorEscalon, BL-
dc.contributor.authorMeyers, SA-
dc.contributor.authorYang, MQ-
dc.contributor.authorPerkins, EJ-
dc.date.accessioned2015-05-14T02:58:43Z-
dc.date.available2015-05-14T02:58:43Z-
dc.date.issued2014-
dc.identifier.citationBMC Genomics, 2014, v. 15 n. Suppl 11, p. S1-
dc.identifier.issn1471-2164-
dc.identifier.urihttp://hdl.handle.net/10722/209726-
dc.description.abstractBackground RDX is a well-known pollutant to induce neurotoxicity. MicroRNAs (miRNA) and messenger RNA (mRNA) profiles are useful tools for toxicogenomics studies. It is worthy to integrate MiRNA and mRNA expression data to understand RDX-induced neurotoxicity. Results Rats were treated with or without RDX for 48 h. Both miRNA and mRNA profiles were conducted using brain tissues. Nine miRNAs were significantly regulated by RDX. Of these, 6 and 3 miRNAs were up- and down-regulated respectively. The putative target genes of RDX-regulated miRNAs were highly nervous system function genes and pathways enriched. Fifteen differentially genes altered by RDX from mRNA profiles were the putative targets of regulated miRNAs. The induction of miR-71, miR-27ab, miR-98, and miR-135a expression by RDX, could reduce the expression of the genes POLE4, C5ORF13, SULF1 and ROCK2, and eventually induce neurotoxicity. Over-expression of miR-27ab, or reduction of the expression of unknown miRNAs by RDX, could up-regulate HMGCR expression and contribute to neurotoxicity. RDX regulated immune and inflammation response miRNAs and genes could contribute to RDX- induced neurotoxicity and other toxicities as well as animal defending reaction response to RDX exposure. Conclusions Our results demonstrate that integrating miRNA and mRNA profiles is valuable to indentify novel biomarkers and molecular mechanisms for RDX-induced neurological disorder and neurotoxicity.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcgenomics/-
dc.relation.ispartofBMC Genomics-
dc.rightsBMC Genomics. Copyright © BioMed Central Ltd.-
dc.titleMicroRNA and messenger RNA profiling reveals new biomarkers and mechanisms for RDX induced neurotoxicity-
dc.typeArticle-
dc.identifier.emailYan, B: yanbinai6017@gmail.com-
dc.identifier.authorityYan, B=rp01940-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1186/1471-2164-15-S11-S1-
dc.identifier.volume15-
dc.identifier.issueSuppl 11-
dc.identifier.spageS1-
dc.identifier.epageS1-
dc.publisher.placeUnited Kingdom-

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