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Article: The injury resistant ability of melanopsin-expressing intrinsically photosensitive retinal ganglion cells

TitleThe injury resistant ability of melanopsin-expressing intrinsically photosensitive retinal ganglion cells
Authors
Issue Date2015
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience
Citation
Neuroscience, 2015, v. 284, p. 845-853 How to Cite?
AbstractNeurons in the mammalian retina expressing the photopigment melanopsin have been identified as a class of intrinsically photosensitive retinal ganglion cells (ipRGCs). This discovery more than a decade ago has opened up an exciting new field of retinal research, and following the initial identification of photosensitive ganglion cells, several subtypes have been described. A number of studies have shown that ipRGCs subserve photoentrainment of circadian rhythms. They also influence other nonimage forming functions of the visual system, such as the pupillary light reflex, sleep, cognition, mood, light aversion and development of the retina. These novel photosensitive neurons also influence form vision by contributing to contrast detection. Furthermore, studies have shown that ipRGCs are more injury-resistant following optic nerve injury, in animal models of glaucoma, and in patients with mitochondrial optic neuropathies, i.e., Leber’s hereditary optic neuropathy and dominant optic atrophy. There is also an indication that these cells may be resistant to glutamateinduced excitotoxicity. Herein we provide an overview of ipRGCs and discuss the injury-resistant character of these neurons under certain pathological and experimental conditions.
Persistent Identifierhttp://hdl.handle.net/10722/209428
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.768

 

DC FieldValueLanguage
dc.contributor.authorCui, Qen_US
dc.contributor.authorRen, Cen_US
dc.contributor.authorSollars, PJen_US
dc.contributor.authorPickard, GEen_US
dc.contributor.authorSo, KFen_US
dc.date.accessioned2015-04-17T05:16:51Z-
dc.date.available2015-04-17T05:16:51Z-
dc.date.issued2015en_US
dc.identifier.citationNeuroscience, 2015, v. 284, p. 845-853en_US
dc.identifier.issn0306-4522en_US
dc.identifier.urihttp://hdl.handle.net/10722/209428-
dc.description.abstractNeurons in the mammalian retina expressing the photopigment melanopsin have been identified as a class of intrinsically photosensitive retinal ganglion cells (ipRGCs). This discovery more than a decade ago has opened up an exciting new field of retinal research, and following the initial identification of photosensitive ganglion cells, several subtypes have been described. A number of studies have shown that ipRGCs subserve photoentrainment of circadian rhythms. They also influence other nonimage forming functions of the visual system, such as the pupillary light reflex, sleep, cognition, mood, light aversion and development of the retina. These novel photosensitive neurons also influence form vision by contributing to contrast detection. Furthermore, studies have shown that ipRGCs are more injury-resistant following optic nerve injury, in animal models of glaucoma, and in patients with mitochondrial optic neuropathies, i.e., Leber’s hereditary optic neuropathy and dominant optic atrophy. There is also an indication that these cells may be resistant to glutamateinduced excitotoxicity. Herein we provide an overview of ipRGCs and discuss the injury-resistant character of these neurons under certain pathological and experimental conditions.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscienceen_US
dc.relation.ispartofNeuroscienceen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in [Neuroscience]. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL 284, (2015)] DOI 10.1016/j.neuroscience.2014.11.002-
dc.titleThe injury resistant ability of melanopsin-expressing intrinsically photosensitive retinal ganglion cellsen_US
dc.typeArticleen_US
dc.identifier.emailSo, KF: hrmaskf@hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.neuroscience.2014.11.002en_US
dc.identifier.pmid25446359en_US
dc.identifier.hkuros242732en_US
dc.identifier.volume284en_US
dc.identifier.spage845en_US
dc.identifier.epage853en_US
dc.publisher.placeNetherlandsen_US

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