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Article: The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma

TitleThe Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma
Authors
Issue Date2015
Citation
Journal of Cancer, 2015, v. 6 n. 4, p. 382-386 How to Cite?
AbstractLung cancer is the top cancer killer worldwide. Tyrosine kinase inhibitors (TKIs), for example erlotinib, are commonly used to target epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma (ADC). Autophagy is a cellular response to stress, serving as a protective mechanism during anticancer therapy. The tumor microenvironment (TME) is composed of non-tumor cells that include fibroblasts. Our study aimed to investigate the effect of TME on autophagy and TKI sensitivity. Following cell sorting after direct co-culturing, autophagy and cytokine production were observed in both HCC827 and MRC-5 cells. The synergistic combination of erlotinib and chloroquine (autophagy inhibitor) was observed under TME. Tumor growth was significantly suppressed with combined erlotinib/chloroquine compared with erlotinib in HCC827 xenografts.
Persistent Identifierhttp://hdl.handle.net/10722/209314

 

DC FieldValueLanguage
dc.contributor.authorLi, YVen_US
dc.contributor.authorLam, SKen_US
dc.contributor.authorZheng, Cen_US
dc.contributor.authorHo, JCMen_US
dc.date.accessioned2015-04-17T05:06:24Z-
dc.date.available2015-04-17T05:06:24Z-
dc.date.issued2015en_US
dc.identifier.citationJournal of Cancer, 2015, v. 6 n. 4, p. 382-386en_US
dc.identifier.urihttp://hdl.handle.net/10722/209314-
dc.description.abstractLung cancer is the top cancer killer worldwide. Tyrosine kinase inhibitors (TKIs), for example erlotinib, are commonly used to target epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma (ADC). Autophagy is a cellular response to stress, serving as a protective mechanism during anticancer therapy. The tumor microenvironment (TME) is composed of non-tumor cells that include fibroblasts. Our study aimed to investigate the effect of TME on autophagy and TKI sensitivity. Following cell sorting after direct co-culturing, autophagy and cytokine production were observed in both HCC827 and MRC-5 cells. The synergistic combination of erlotinib and chloroquine (autophagy inhibitor) was observed under TME. Tumor growth was significantly suppressed with combined erlotinib/chloroquine compared with erlotinib in HCC827 xenografts.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Canceren_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleThe Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinomaen_US
dc.typeArticleen_US
dc.identifier.emailLi, YV: avicky@hku.hken_US
dc.identifier.emailLam, SK: sklam77@hku.hken_US
dc.identifier.emailZheng, C: ald324@hku.hken_US
dc.identifier.emailHo, JCM: jhocm@hku.hken_US
dc.identifier.authorityHo, JCM=rp00258en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.7150/jca.11187en_US
dc.identifier.hkuros242817en_US
dc.identifier.volume6en_US
dc.identifier.spage382en_US
dc.identifier.epage386en_US

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