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Article: Epidermal growth factor-induced epithelial–mesenchymal transition in human esophageal carcinoma cells – A model for the study of metastasis

TitleEpidermal growth factor-induced epithelial–mesenchymal transition in human esophageal carcinoma cells – A model for the study of metastasis
Authors
KeywordsEpidermal growth factor
Epithelial–mesenchymal transition
Esophageal squamous cell carcinoma
Metastasis
Issue Date2010
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2010, v. 296 n. 1, p. 88-95 How to Cite?
AbstractDeciphering the molecular basis of esophageal cancer metastasis requires adequate experimental models. Epithelial–mesenchymal transition (EMT) is the hallmark of tumor metastasis. As a promoter of the malignant progression of esophageal cancer, epidermal growth factor (EGF) has been shown to induce EMT in several cell lines. In this study we examined the effects of EGF on esophageal carcinoma EC109 cells. We found that EGF at high concentration induced the cells to undergo morphological change, exhibit higher invasive and metastatic potential, as well as change in the expression of lineage markers. This EMT model might facilitate mechanistic studies of esophageal cancer metastasis.
Persistent Identifierhttp://hdl.handle.net/10722/209245
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331

 

DC FieldValueLanguage
dc.contributor.authorCai, Z-
dc.contributor.authorWang, Q-
dc.contributor.authorZhou, Y-
dc.contributor.authorZheng, L-
dc.contributor.authorChiu, J-
dc.contributor.authorHe, QY-
dc.date.accessioned2015-04-14T04:08:39Z-
dc.date.available2015-04-14T04:08:39Z-
dc.date.issued2010-
dc.identifier.citationCancer Letters, 2010, v. 296 n. 1, p. 88-95-
dc.identifier.issn0304-3835-
dc.identifier.urihttp://hdl.handle.net/10722/209245-
dc.description.abstractDeciphering the molecular basis of esophageal cancer metastasis requires adequate experimental models. Epithelial–mesenchymal transition (EMT) is the hallmark of tumor metastasis. As a promoter of the malignant progression of esophageal cancer, epidermal growth factor (EGF) has been shown to induce EMT in several cell lines. In this study we examined the effects of EGF on esophageal carcinoma EC109 cells. We found that EGF at high concentration induced the cells to undergo morphological change, exhibit higher invasive and metastatic potential, as well as change in the expression of lineage markers. This EMT model might facilitate mechanistic studies of esophageal cancer metastasis.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet-
dc.relation.ispartofCancer Letters-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in [Journal title]. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI# -
dc.subjectEpidermal growth factor-
dc.subjectEpithelial–mesenchymal transition-
dc.subjectEsophageal squamous cell carcinoma-
dc.subjectMetastasis-
dc.titleEpidermal growth factor-induced epithelial–mesenchymal transition in human esophageal carcinoma cells – A model for the study of metastasis-
dc.typeArticle-
dc.identifier.emailZhou, Y: yzhou@hku.hk-
dc.identifier.emailChiu, J: jfchiu@hkucc.hku.hk-
dc.identifier.doi10.1016/j.canlet.2010.03.020-
dc.identifier.hkuros196621-
dc.identifier.volume296-
dc.identifier.issue1-
dc.identifier.spage88-
dc.identifier.epage95-
dc.publisher.placeIreland-

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