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Article: Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma

TitleMolecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma
Authors
Issue Date2010
PublisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/
Citation
Blood, 2010, v. 115 n. 5, p. 1026-1036 How to Cite?
AbstractPeripheral T-cell lymphoma (PTCL) is often challenging to diagnose and classify. Gene expression profiling was performed on 144 cases of PTCL and natural killer cell lymphoma and robust molecular classifiers were constructed for angioimmunoblastic T-cell lymphoma (AITL), anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large-cell lymphoma (ALCL), and adult T-cell leukemia/lymphoma. PTCL-unclassifiable was molecularly heterogeneous, but we were able to identify a molecular subgroup with features of cytotoxic T lymphocytes and a poor survival compared with the remaining PTCL-not otherwise specified cases. Many of the pathologic features and substantial components of the molecular signature of AITL are contributed by the follicular dendritic cells, B-cell, and other stromal components. The expression of Th17-associated molecules in ALK(+) ALCL was noted and may represent aberrant activation of Th17-cell differentiation by abnormal cytokine secretion. Adult T-cell leukemia/lymphoma has a homogeneous molecular signature demonstrating high expression of human T-lymphotropic virus type 1-induced genes. These classifiers reflect the biology of the tumor cells as well as their microenvironment. We also constructed a molecular prognosticator for AITL that appears to be largely related to the microenvironmental signature, and the high expression of 2 immunosuppressive signatures are associated with poor outcome. Oncogenic pathways and tumor-host interactions also were identified, and these findings may lead to better therapies and outcome in the future.
Persistent Identifierhttp://hdl.handle.net/10722/209200
ISSN
2015 Impact Factor: 11.841
2015 SCImago Journal Rankings: 6.395
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorIqbal, J-
dc.contributor.authorWeisenburger, DD-
dc.contributor.authorGreiner, TC-
dc.contributor.authorVose, JM-
dc.contributor.authorMcKeithan, T-
dc.contributor.authorKucuk, C-
dc.contributor.authorGeng, H-
dc.contributor.authorDeffenbacher, K-
dc.contributor.authorSmith, L-
dc.contributor.authorDybkaer, K-
dc.contributor.authorNakamura, S-
dc.contributor.authorSeto, M-
dc.contributor.authorDelabie, J-
dc.contributor.authorBerger, F-
dc.contributor.authorLoong, F-
dc.contributor.authorAu, WY-
dc.contributor.authorKo, YH-
dc.contributor.authorSng, I-
dc.contributor.authorArmitage, JO-
dc.contributor.authorChan, WC-
dc.date.accessioned2015-04-09T07:21:40Z-
dc.date.available2015-04-09T07:21:40Z-
dc.date.issued2010-
dc.identifier.citationBlood, 2010, v. 115 n. 5, p. 1026-1036-
dc.identifier.issn0006-4971-
dc.identifier.urihttp://hdl.handle.net/10722/209200-
dc.description.abstractPeripheral T-cell lymphoma (PTCL) is often challenging to diagnose and classify. Gene expression profiling was performed on 144 cases of PTCL and natural killer cell lymphoma and robust molecular classifiers were constructed for angioimmunoblastic T-cell lymphoma (AITL), anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large-cell lymphoma (ALCL), and adult T-cell leukemia/lymphoma. PTCL-unclassifiable was molecularly heterogeneous, but we were able to identify a molecular subgroup with features of cytotoxic T lymphocytes and a poor survival compared with the remaining PTCL-not otherwise specified cases. Many of the pathologic features and substantial components of the molecular signature of AITL are contributed by the follicular dendritic cells, B-cell, and other stromal components. The expression of Th17-associated molecules in ALK(+) ALCL was noted and may represent aberrant activation of Th17-cell differentiation by abnormal cytokine secretion. Adult T-cell leukemia/lymphoma has a homogeneous molecular signature demonstrating high expression of human T-lymphotropic virus type 1-induced genes. These classifiers reflect the biology of the tumor cells as well as their microenvironment. We also constructed a molecular prognosticator for AITL that appears to be largely related to the microenvironmental signature, and the high expression of 2 immunosuppressive signatures are associated with poor outcome. Oncogenic pathways and tumor-host interactions also were identified, and these findings may lead to better therapies and outcome in the future.-
dc.languageeng-
dc.publisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/-
dc.relation.ispartofBlood-
dc.rightsThis research was originally published in The Hematologist: ASH News and Reports. Author(s). Title. The Hematologist: ASH News and Reports. Year;Vol,Issue:pp-pp. © the American Society of Hematology.-
dc.titleMolecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma-
dc.typeArticle-
dc.identifier.emailLoong, F: floong@HKUCC.hku.hk-
dc.identifier.emailAu, WY: auwing@HKUCC.hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid19965671-
dc.identifier.pmcidPMC2817630-
dc.identifier.hkuros180712-
dc.identifier.volume115-
dc.identifier.issue5-
dc.identifier.spage1026-
dc.identifier.epage1036-
dc.publisher.placeUnited States-

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