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Article: Choosing preclinical study models of diabetic retinopathy: key problems for consideration

TitleChoosing preclinical study models of diabetic retinopathy: key problems for consideration
Authors
Issue Date2014
PublisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?issue_id=142
Citation
Drug Design, Development and Therapy, 2014, v. 8, p. 2311-2319 How to Cite?
AbstractDiabetic retinopathy (DR) is the most common complication of diabetes mellitus in the eye. Although the clinical treatment for DR has already developed to a relative high level, there are still many urgent problems that need to be investigated in clinical and basic science. Currently, many in vivo animal models and in vitro culture systems have been applied to solve these problems. Many approaches have also been used to establish different DR models. However, till now, there has not been a single study model that can clearly and exactly mimic the developmental process of the human DR. Choosing the suitable model is important, not only for achieving our research goals smoothly, but also, to better match with different experimental proposals in the study. In this review, key problems for consideration in choosing study models of DR are discussed. These problems relate to clinical relevance, different approaches for establishing models, and choice of different species of animals as well as of the specific in vitro culture systems. Attending to these considerations will deepen the understanding on current study models and optimize the experimental design for the final goal of preventing DR.
Persistent Identifierhttp://hdl.handle.net/10722/208786
ISSN
2015 Impact Factor: 2.881
2015 SCImago Journal Rankings: 0.931
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorMi, X-
dc.contributor.authorYuan, TF-
dc.contributor.authorDing, Y-
dc.contributor.authorZhong, JX-
dc.contributor.authorSo, KF-
dc.date.accessioned2015-03-18T09:13:02Z-
dc.date.available2015-03-18T09:13:02Z-
dc.date.issued2014-
dc.identifier.citationDrug Design, Development and Therapy, 2014, v. 8, p. 2311-2319-
dc.identifier.issn1177-8881-
dc.identifier.urihttp://hdl.handle.net/10722/208786-
dc.description.abstractDiabetic retinopathy (DR) is the most common complication of diabetes mellitus in the eye. Although the clinical treatment for DR has already developed to a relative high level, there are still many urgent problems that need to be investigated in clinical and basic science. Currently, many in vivo animal models and in vitro culture systems have been applied to solve these problems. Many approaches have also been used to establish different DR models. However, till now, there has not been a single study model that can clearly and exactly mimic the developmental process of the human DR. Choosing the suitable model is important, not only for achieving our research goals smoothly, but also, to better match with different experimental proposals in the study. In this review, key problems for consideration in choosing study models of DR are discussed. These problems relate to clinical relevance, different approaches for establishing models, and choice of different species of animals as well as of the specific in vitro culture systems. Attending to these considerations will deepen the understanding on current study models and optimize the experimental design for the final goal of preventing DR.-
dc.languageeng-
dc.publisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?issue_id=142-
dc.relation.ispartofDrug Design, Development and Therapy-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleChoosing preclinical study models of diabetic retinopathy: key problems for consideration-
dc.typeArticle-
dc.identifier.emailMi, X: mxsong@hku.hk-
dc.identifier.emailYuan, TF: tfyuan@hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.authoritySo, KF=rp00329-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2147/DDDT.S72797-
dc.identifier.pmid25429204-
dc.identifier.pmcidPMC4242133-
dc.identifier.hkuros242710-
dc.identifier.volume8-
dc.identifier.spage2311-
dc.identifier.epage2319-
dc.publisher.placeNew Zealand-

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