File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Efficacy of selective laser trabeculoplasty for normal tension glaucoma: 1 year results

TitleEfficacy of selective laser trabeculoplasty for normal tension glaucoma: 1 year results
Authors
Issue Date2015
Citation
BMC Ophthalmology, 2015, v. 15, article no. 1 How to Cite?
AbstractBACKGROUND: Normal tension glaucoma (NTG) is commonly treated with anti-glaucoma medications. Recently, selective laser trabeculoplasty (SLT) has been demonstrated to lower the intraocular pressure (IOP) and medication use in NTG. The purpose of this study was to investigate the efficacy of a single session of SLT for NTG at 1 year. METHODS: This prospective cohort study recruited NTG patients taking anti-glaucoma medication. Potential subjects were excluded if they had had previous glaucoma surgery or laser and also if intraocular surgery or additional SLT procedures were performed after the first treatment. All subjects underwent a 1-month washout. A 30% IOP reduction was set as the target IOP. A single session of SLT was performed to 360 degrees of the trabecular meshwork. At 1-month after SLT, medication was resumed to achieve the target IOP. The IOP was measured every 3 months, and the number of medications was recorded at 3, 6, and 12 months. Only the right eye was used for statistical analysis. RESULTS: In 41 right eyes, the mean pre-study IOP was 14.3 +/- 3.4 mmHg while on 1.5 +/- 0.8 eye drops. The post-washout IOP was 16.2 +/- 2.2 mmHg. A mean of 191.1 +/- 26.3 SLT shots at 1.0 +/- 0.07 mJ were applied. There was significant IOP reduction at all time intervals following SLT when compared to the post-washout IOP (P < 0.0001). The number of medications was significantly reduced at all time intervals following SLT when compared to the pre-study level (P < 0.0001). At 12 months, the mean IOP was 12.2 +/- 2.2 mmHg while on 1.1 +/- 0.9 eye drops. CONCLUSIONS: A single session of SLT for NTG achieved an additional 15% IOP reduction while using 27% less medication at 1 year compared to pre-study levels.Trial registration: The Clinical Trials Register of the University of Hong Kong HKCTR1847The European Clinical Trials Database 2014-003305-15 (August 11, 2014) (https://eudract.ema.europa.eu/).
Persistent Identifierhttp://hdl.handle.net/10722/208505
ISSN
2015 Impact Factor: 1.238
2015 SCImago Journal Rankings: 0.938
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, WYJen_US
dc.contributor.authorHo, WLen_US
dc.contributor.authorChan, JCen_US
dc.contributor.authorLai, JSen_US
dc.date.accessioned2015-03-11T07:06:29Z-
dc.date.available2015-03-11T07:06:29Z-
dc.date.issued2015en_US
dc.identifier.citationBMC Ophthalmology, 2015, v. 15, article no. 1en_US
dc.identifier.issn1471-2415en_US
dc.identifier.urihttp://hdl.handle.net/10722/208505-
dc.description.abstractBACKGROUND: Normal tension glaucoma (NTG) is commonly treated with anti-glaucoma medications. Recently, selective laser trabeculoplasty (SLT) has been demonstrated to lower the intraocular pressure (IOP) and medication use in NTG. The purpose of this study was to investigate the efficacy of a single session of SLT for NTG at 1 year. METHODS: This prospective cohort study recruited NTG patients taking anti-glaucoma medication. Potential subjects were excluded if they had had previous glaucoma surgery or laser and also if intraocular surgery or additional SLT procedures were performed after the first treatment. All subjects underwent a 1-month washout. A 30% IOP reduction was set as the target IOP. A single session of SLT was performed to 360 degrees of the trabecular meshwork. At 1-month after SLT, medication was resumed to achieve the target IOP. The IOP was measured every 3 months, and the number of medications was recorded at 3, 6, and 12 months. Only the right eye was used for statistical analysis. RESULTS: In 41 right eyes, the mean pre-study IOP was 14.3 +/- 3.4 mmHg while on 1.5 +/- 0.8 eye drops. The post-washout IOP was 16.2 +/- 2.2 mmHg. A mean of 191.1 +/- 26.3 SLT shots at 1.0 +/- 0.07 mJ were applied. There was significant IOP reduction at all time intervals following SLT when compared to the post-washout IOP (P < 0.0001). The number of medications was significantly reduced at all time intervals following SLT when compared to the pre-study level (P < 0.0001). At 12 months, the mean IOP was 12.2 +/- 2.2 mmHg while on 1.1 +/- 0.9 eye drops. CONCLUSIONS: A single session of SLT for NTG achieved an additional 15% IOP reduction while using 27% less medication at 1 year compared to pre-study levels.Trial registration: The Clinical Trials Register of the University of Hong Kong HKCTR1847The European Clinical Trials Database 2014-003305-15 (August 11, 2014) (https://eudract.ema.europa.eu/).en_US
dc.languageengen_US
dc.relation.ispartofBMC Ophthalmologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleEfficacy of selective laser trabeculoplasty for normal tension glaucoma: 1 year resultsen_US
dc.typeArticleen_US
dc.identifier.emailLee, WYJ: jackylee@hku.hken_US
dc.identifier.authorityLee, WYJ=rp01498en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1471-2415-15-1en_US
dc.identifier.pmid25571769-
dc.identifier.hkuros264616-
dc.identifier.volume15en_US
dc.identifier.spagearticle no. 1en_US
dc.identifier.epagearticle no. 1en_US
dc.identifier.isiWOS:000349044400001-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats