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Article: Cross-sectional study of the retinal nerve fiber layer thickness at 7 years after an acute episode of unilateral primary acute angle closure

TitleCross-sectional study of the retinal nerve fiber layer thickness at 7 years after an acute episode of unilateral primary acute angle closure
Authors
Issue Date2015
Citation
Medicine (Baltimore), 2015, v. 94 n. 2, p. e391-e391 How to Cite?
AbstractThe purpose of this article is to investigate the long-term retinal nerve fiber layer (RNFL) status and determinants of RNFL thinning after an episode of unilateral primary acute angle closure (AAC).This cross-sectional study analyzed the medical records of consecutive patients with a single episode of unilateral AAC from 1999 to 2009 in Hong Kong. The peripapillary RNFL thickness was correlated with age, gender, presenting intraocular pressure (IOP), time to laser iridotomy, time to cataract extraction, follow-up duration, as well as the last IOP, vertical cup-to-disc ratio (CDR), and vision. The fellow uninvolved eye was used as a proxy comparison of RNFL loss in the attack eye.In 40 eligible patients, the mean age was 68.3 +/- 8.7 years with a male-to-female ratio of 1:7. The mean presenting IOP was 49.2 +/- 14.0 mm Hg and the time from presentation to laser iridotomy was 6.7 +/- 6.9 days. Forty percent of subjects received a cataract extraction at 3.2 +/- 2.9 years after the attack. The last IOP, CDR, and LogMAR vision were 16.0 +/- 3.8 mm Hg, 0.6 +/- 0.2, and 0.6 +/- 0.6 LogMAR units, respectively, at 7.9 +/- 2.4 years. The RNFL thickness in the attack eye (69.2 +/- 19.1 mum) was 25.2 +/- 17.9% thinner than the fellow eye (93.0 +/- 17.8 mum) at 7.5 +/- 2.9 years post-AAC. Using univariate analysis, the last vertical CDR (odds ratio [OR] = 17.2, P = 0.049) and LogMAR visual acuity (VA) (OR = 6.6, P = 0.03) were the only significant predictors for RNFL thinning whereas none of the other covariates showed significant associations (P > 0.1).At 7.5 years following unilateral AAC, the RNFL thickness was 25% thinner than the fellow eye. CDR enlargement and poor VA were the only significant predictors for RNFL loss.
Persistent Identifierhttp://hdl.handle.net/10722/208503
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, WYJen_US
dc.contributor.authorWoo, TTen_US
dc.contributor.authorYau, GSen_US
dc.contributor.authorYip, Sen_US
dc.contributor.authorYick, DWen_US
dc.contributor.authorWong, Jen_US
dc.contributor.authorWong, RLen_US
dc.contributor.authorWong, IYen_US
dc.date.accessioned2015-03-11T07:06:28Z-
dc.date.available2015-03-11T07:06:28Z-
dc.date.issued2015en_US
dc.identifier.citationMedicine (Baltimore), 2015, v. 94 n. 2, p. e391-e391en_US
dc.identifier.issn1536-5964en_US
dc.identifier.urihttp://hdl.handle.net/10722/208503-
dc.description.abstractThe purpose of this article is to investigate the long-term retinal nerve fiber layer (RNFL) status and determinants of RNFL thinning after an episode of unilateral primary acute angle closure (AAC).This cross-sectional study analyzed the medical records of consecutive patients with a single episode of unilateral AAC from 1999 to 2009 in Hong Kong. The peripapillary RNFL thickness was correlated with age, gender, presenting intraocular pressure (IOP), time to laser iridotomy, time to cataract extraction, follow-up duration, as well as the last IOP, vertical cup-to-disc ratio (CDR), and vision. The fellow uninvolved eye was used as a proxy comparison of RNFL loss in the attack eye.In 40 eligible patients, the mean age was 68.3 +/- 8.7 years with a male-to-female ratio of 1:7. The mean presenting IOP was 49.2 +/- 14.0 mm Hg and the time from presentation to laser iridotomy was 6.7 +/- 6.9 days. Forty percent of subjects received a cataract extraction at 3.2 +/- 2.9 years after the attack. The last IOP, CDR, and LogMAR vision were 16.0 +/- 3.8 mm Hg, 0.6 +/- 0.2, and 0.6 +/- 0.6 LogMAR units, respectively, at 7.9 +/- 2.4 years. The RNFL thickness in the attack eye (69.2 +/- 19.1 mum) was 25.2 +/- 17.9% thinner than the fellow eye (93.0 +/- 17.8 mum) at 7.5 +/- 2.9 years post-AAC. Using univariate analysis, the last vertical CDR (odds ratio [OR] = 17.2, P = 0.049) and LogMAR visual acuity (VA) (OR = 6.6, P = 0.03) were the only significant predictors for RNFL thinning whereas none of the other covariates showed significant associations (P > 0.1).At 7.5 years following unilateral AAC, the RNFL thickness was 25% thinner than the fellow eye. CDR enlargement and poor VA were the only significant predictors for RNFL loss.en_US
dc.languageengen_US
dc.relation.ispartofMedicine (Baltimore)en_US
dc.titleCross-sectional study of the retinal nerve fiber layer thickness at 7 years after an acute episode of unilateral primary acute angle closureen_US
dc.typeArticleen_US
dc.identifier.emailLee, WYJ: jackylee@hku.hken_US
dc.identifier.authorityLee, WYJ=rp01498en_US
dc.identifier.doi10.1097/MD.0000000000000391en_US
dc.identifier.pmid25590844-
dc.identifier.scopuseid_2-s2.0-84921941447-
dc.identifier.volume94en_US
dc.identifier.issue2en_US
dc.identifier.spagee391en_US
dc.identifier.epagee391en_US
dc.identifier.isiWOS:000348142400018-

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