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Article: Prospective study on retinal nerve fibre layer thickness changes in isolated unilateral retrobulbar optic neuritis

TitleProspective study on retinal nerve fibre layer thickness changes in isolated unilateral retrobulbar optic neuritis
Authors
KeywordsAdolescent
Aged
Aged, 80 and over
Anti-Inflammatory Agents/*therapeutic use
Cohort Studies
Female
Humans
Male
Middle Aged
Nerve Fibers/drug effects/*pathology
Optic Neuritis/*drug therapy/*pathology
Organ Size/drug effects
Prospective Studies
Reproducibility of Results
Retinal Ganglion Cells/drug effects/*pathology
Sensitivity and Specificity
Tomography, Optical Coherence/*methods
Treatment Outcome
Young Adult
Issue Date2013
Citation
The Scientific World Journal, 2013, v. 2013, p. 694613-694613 How to Cite?
AbstractPURPOSE: To investigate the retinal nerve fibre layer (RNFL) thickness after unilateral acute optic neuritis using optical coherence tomography (OCT). PATIENTS AND METHODS: This prospective cohort study recruited consecutive patients with a first episode of isolated, unilateral acute optic neuritis. RNFL thickness and visual acuity (VA) of the attack and normal fellow eye were measured at presentation and 3 months in both the treatment and nontreatment groups. RESULTS: 11 subjects received systemic steroids and 9 were treated conservatively. The baseline RNFL thickness was similar in the attack and fellow eye (P >/= 0.4). At 3 months, the attack eye had a thinner temporal (P = 0.02) and average (P = 0.05) RNFL compared to the fellow eye. At 3 months, the attack eye had significant RNFL thinning in the 4 quadrants and average thickness (P /= 0.1). Treatment offered better VA at 3 months (0.1 +/- 0.2 versus 0.3 +/- 0.2 LogMAR, P = 0.04). CONCLUSION: Generalized RNFL thinning occurred at 3 months after a first episode of acute optic neuritis most significantly in the temporal quadrant and average thickness. Visual improvement with treatment was independent of RNFL thickness.
Persistent Identifierhttp://hdl.handle.net/10722/208495
ISSN
2013 Impact Factor: 1.219
2015 SCImago Journal Rankings: 0.315

 

DC FieldValueLanguage
dc.contributor.authorYau, GSen_US
dc.contributor.authorLee, WYJen_US
dc.contributor.authorLau, PPen_US
dc.contributor.authorTam, VTen_US
dc.contributor.authorWong, WWen_US
dc.contributor.authorYuen, CYen_US
dc.date.accessioned2015-03-11T07:06:25Z-
dc.date.available2015-03-11T07:06:25Z-
dc.date.issued2013en_US
dc.identifier.citationThe Scientific World Journal, 2013, v. 2013, p. 694613-694613en_US
dc.identifier.issn1537-744Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/208495-
dc.description.abstractPURPOSE: To investigate the retinal nerve fibre layer (RNFL) thickness after unilateral acute optic neuritis using optical coherence tomography (OCT). PATIENTS AND METHODS: This prospective cohort study recruited consecutive patients with a first episode of isolated, unilateral acute optic neuritis. RNFL thickness and visual acuity (VA) of the attack and normal fellow eye were measured at presentation and 3 months in both the treatment and nontreatment groups. RESULTS: 11 subjects received systemic steroids and 9 were treated conservatively. The baseline RNFL thickness was similar in the attack and fellow eye (P >/= 0.4). At 3 months, the attack eye had a thinner temporal (P = 0.02) and average (P = 0.05) RNFL compared to the fellow eye. At 3 months, the attack eye had significant RNFL thinning in the 4 quadrants and average thickness (P </= 0.0002) compared to baseline. The RNFL thickness between the treatment and nontreatment groups was similar at baseline and 3 months (P >/= 0.1). Treatment offered better VA at 3 months (0.1 +/- 0.2 versus 0.3 +/- 0.2 LogMAR, P = 0.04). CONCLUSION: Generalized RNFL thinning occurred at 3 months after a first episode of acute optic neuritis most significantly in the temporal quadrant and average thickness. Visual improvement with treatment was independent of RNFL thickness.en_US
dc.languageengen_US
dc.relation.ispartofThe Scientific World Journalen_US
dc.subjectAdolescenten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectAnti-Inflammatory Agents/*therapeutic useen_US
dc.subjectCohort Studiesen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectNerve Fibers/drug effects/*pathologyen_US
dc.subjectOptic Neuritis/*drug therapy/*pathologyen_US
dc.subjectOrgan Size/drug effectsen_US
dc.subjectProspective Studiesen_US
dc.subjectReproducibility of Resultsen_US
dc.subjectRetinal Ganglion Cells/drug effects/*pathologyen_US
dc.subjectSensitivity and Specificityen_US
dc.subjectTomography, Optical Coherence/*methodsen_US
dc.subjectTreatment Outcomeen_US
dc.subjectYoung Adulten_US
dc.titleProspective study on retinal nerve fibre layer thickness changes in isolated unilateral retrobulbar optic neuritisen_US
dc.typeArticleen_US
dc.identifier.emailLee, WYJ: jackylee@hku.hken_US
dc.identifier.authorityLee, WYJ=rp01498en_US
dc.identifier.doi10.1155/2013/694613en_US
dc.identifier.pmid24459442-
dc.identifier.scopuseid_2-s2.0-84896342494-
dc.identifier.volume2013en_US
dc.identifier.spage694613en_US
dc.identifier.epage694613en_US

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