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Article: Twenty-four-hour intraocular pressure related changes following adjuvant selective laser trabeculoplasty for normal tension glaucoma

TitleTwenty-four-hour intraocular pressure related changes following adjuvant selective laser trabeculoplasty for normal tension glaucoma
Authors
Issue Date2014
Citation
Medicine (United States), 2014, v. 93 n. 27, p. e238-e238 How to Cite?
AbstractTo investigate intraocular pressure (IOP) related patterns before and after selective laser trabeculoplasty (SLT) for normal tension glaucoma (NTG).In this prospective cohort study, 18 NTG patients underwent SLT. Success was defined as IOP reduction >/= 20% by Goldmann applanation tonometry. 24-hour IOP-related pattern recording with a contact lens sensor (CLS) (SENSIMED Triggerfish, Sensimed, Switzerland) was done before (baseline) and 1 month after SLT. A cosine function was fitted to the mean CLS patterns for each individual in the SLT success and non-success groups and the amplitude before and after SLT was calculated. Diurnal, nocturnal, and 24-hour CLS pattern local variability was determined for pre- and post-SLT sessions. Cosine amplitude and variability were compared before and after SLT by group using paired t-tests, with alpha = 0.05. Patients (11 women, 7 men) had a mean age of 65.1 +/- 13.7 years. Mean IOP was 15.3 +/- 2.2 mm Hg at baseline and was reduced by 17.0% to 12.7 +/- 1.8 mm Hg 1 month after SLT (P = 0.001). SLT was successful in 8 patients (44%). The amplitude of the fitted cosine was reduced by 24.6% in the success group, but displayed an amplitude increase of 19.2% post-SLT in the non-success group. Higher diurnal local variability of the CLS pattern was observed after SLT in non-success subjects (P = 0.002), while nocturnal variability showed no significant change. The increase in diurnal variability in the non-success group led to an increase in 24-hour variability in this group (P = 0.001). No change in local variability (diurnal, nocturnal, and 24-hour) was seen in the success group. The IOP-related pattern cosinor amplitude was reduced in NTG patients with a successful SLT treatment whereas the non-success group exhibited an increase of cosine amplitude. Higher diurnal and 24-hour CLS pattern variability was observed in non-success patients 1 month post-SLT.
Persistent Identifierhttp://hdl.handle.net/10722/208488
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, WYJen_US
dc.contributor.authorFu, Len_US
dc.contributor.authorChan, JCen_US
dc.contributor.authorLai, JSen_US
dc.date.accessioned2015-03-11T07:06:22Z-
dc.date.available2015-03-11T07:06:22Z-
dc.date.issued2014en_US
dc.identifier.citationMedicine (United States), 2014, v. 93 n. 27, p. e238-e238en_US
dc.identifier.issn1536-5964en_US
dc.identifier.urihttp://hdl.handle.net/10722/208488-
dc.description.abstractTo investigate intraocular pressure (IOP) related patterns before and after selective laser trabeculoplasty (SLT) for normal tension glaucoma (NTG).In this prospective cohort study, 18 NTG patients underwent SLT. Success was defined as IOP reduction >/= 20% by Goldmann applanation tonometry. 24-hour IOP-related pattern recording with a contact lens sensor (CLS) (SENSIMED Triggerfish, Sensimed, Switzerland) was done before (baseline) and 1 month after SLT. A cosine function was fitted to the mean CLS patterns for each individual in the SLT success and non-success groups and the amplitude before and after SLT was calculated. Diurnal, nocturnal, and 24-hour CLS pattern local variability was determined for pre- and post-SLT sessions. Cosine amplitude and variability were compared before and after SLT by group using paired t-tests, with alpha = 0.05. Patients (11 women, 7 men) had a mean age of 65.1 +/- 13.7 years. Mean IOP was 15.3 +/- 2.2 mm Hg at baseline and was reduced by 17.0% to 12.7 +/- 1.8 mm Hg 1 month after SLT (P = 0.001). SLT was successful in 8 patients (44%). The amplitude of the fitted cosine was reduced by 24.6% in the success group, but displayed an amplitude increase of 19.2% post-SLT in the non-success group. Higher diurnal local variability of the CLS pattern was observed after SLT in non-success subjects (P = 0.002), while nocturnal variability showed no significant change. The increase in diurnal variability in the non-success group led to an increase in 24-hour variability in this group (P = 0.001). No change in local variability (diurnal, nocturnal, and 24-hour) was seen in the success group. The IOP-related pattern cosinor amplitude was reduced in NTG patients with a successful SLT treatment whereas the non-success group exhibited an increase of cosine amplitude. Higher diurnal and 24-hour CLS pattern variability was observed in non-success patients 1 month post-SLT.en_US
dc.languageengen_US
dc.relation.ispartofMedicine (United States)en_US
dc.titleTwenty-four-hour intraocular pressure related changes following adjuvant selective laser trabeculoplasty for normal tension glaucomaen_US
dc.typeArticleen_US
dc.identifier.emailLee, WYJ: jackylee@hku.hken_US
dc.identifier.authorityLee, WYJ=rp01498en_US
dc.identifier.doi10.1097/MD.0000000000000238en_US
dc.identifier.scopuseid_2-s2.0-84919388684-
dc.identifier.volume93en_US
dc.identifier.issue27en_US
dc.identifier.spagee238en_US
dc.identifier.epagee238en_US
dc.identifier.isiWOS:000346406500043-

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