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Article: Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2

TitleWnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2
Authors
KeywordsAnimals
*Cell Polarity
Embryonic Development
Fibroblasts/*cytology/*metabolism
Mice
Models, Biological
Nerve Tissue Proteins/*metabolism
Phosphorylation
Protein Binding
Protein Transport
Receptor Tyrosine Kinase-like Orphan Receptors/*metabolism
*Signal Transduction
Wnt Proteins/antagonists & inhibitors/*metabolism
beta Catenin/metabolism
Issue Date2011
Citation
Developmental Cell, 2011, v. 20 n. 2, p. 163-176 How to Cite?
AbstractIt is fundamentally important that signaling gradients provide positional information to govern morphogenesis of multicellular organisms. Morphogen gradients can generate different cell types in specific spatial order at distinct threshold concentrations. However, it is largely unknown whether and how signaling gradients also control cell polarities by acting as global cues. Here, we show that Wnt signaling gradient provides directional information to a field of cells. Vangl2, a core component in planar cell polarity, forms Wnt-induced receptor complex with Ror2 to sense Wnt dosages. Wnts dose-dependently induce Vangl2 phosphorylation of serine/threonine residues and Vangl2 activities depend on its levels of phosphorylation. In the limb bud, Wnt5a signaling gradient controls limb elongation by establishing PCP in chondrocytes along the proximal-distal axis through regulating Vangl2 phosphorylation. Our studies have provided new insight to Robinow syndrome, Brachydactyly Type B1, and spinal bifida which are caused by mutations in human ROR2, WNT5A, or VANGL.
Persistent Identifierhttp://hdl.handle.net/10722/208447
ISSN
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGao, Ben_US
dc.contributor.authorSong, Hen_US
dc.contributor.authorBishop, Ken_US
dc.contributor.authorElliot, Gen_US
dc.contributor.authorGarrett, Len_US
dc.contributor.authorEnglish, MAen_US
dc.contributor.authorAndre, Pen_US
dc.contributor.authorRobinson, Jen_US
dc.contributor.authorSood, Ren_US
dc.contributor.authorMinami, Yen_US
dc.contributor.authorEconomides, ANen_US
dc.contributor.authorYang, Yen_US
dc.date.accessioned2015-03-11T03:01:06Z-
dc.date.available2015-03-11T03:01:06Z-
dc.date.issued2011en_US
dc.identifier.citationDevelopmental Cell, 2011, v. 20 n. 2, p. 163-176en_US
dc.identifier.issn1878-1551en_US
dc.identifier.urihttp://hdl.handle.net/10722/208447-
dc.description.abstractIt is fundamentally important that signaling gradients provide positional information to govern morphogenesis of multicellular organisms. Morphogen gradients can generate different cell types in specific spatial order at distinct threshold concentrations. However, it is largely unknown whether and how signaling gradients also control cell polarities by acting as global cues. Here, we show that Wnt signaling gradient provides directional information to a field of cells. Vangl2, a core component in planar cell polarity, forms Wnt-induced receptor complex with Ror2 to sense Wnt dosages. Wnts dose-dependently induce Vangl2 phosphorylation of serine/threonine residues and Vangl2 activities depend on its levels of phosphorylation. In the limb bud, Wnt5a signaling gradient controls limb elongation by establishing PCP in chondrocytes along the proximal-distal axis through regulating Vangl2 phosphorylation. Our studies have provided new insight to Robinow syndrome, Brachydactyly Type B1, and spinal bifida which are caused by mutations in human ROR2, WNT5A, or VANGL.en_US
dc.languageengen_US
dc.relation.ispartofDevelopmental Cellen_US
dc.subjectAnimalsen_US
dc.subject*Cell Polarityen_US
dc.subjectEmbryonic Developmenten_US
dc.subjectFibroblasts/*cytology/*metabolismen_US
dc.subjectMiceen_US
dc.subjectModels, Biologicalen_US
dc.subjectNerve Tissue Proteins/*metabolismen_US
dc.subjectPhosphorylationen_US
dc.subjectProtein Bindingen_US
dc.subjectProtein Transporten_US
dc.subjectReceptor Tyrosine Kinase-like Orphan Receptors/*metabolismen_US
dc.subject*Signal Transductionen_US
dc.subjectWnt Proteins/antagonists & inhibitors/*metabolismen_US
dc.subjectbeta Catenin/metabolismen_US
dc.titleWnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2en_US
dc.typeArticleen_US
dc.identifier.emailGao, B: gaobo@hku.hken_US
dc.identifier.authorityGao, B=rp02012en_US
dc.identifier.doi10.1016/j.devcel.2011.01.001en_US
dc.identifier.pmid21316585-
dc.identifier.pmcid3062198-
dc.identifier.scopuseid_2-s2.0-79751515852-
dc.identifier.volume20en_US
dc.identifier.issue2en_US
dc.identifier.spage163en_US
dc.identifier.epage176en_US
dc.identifier.isiWOS:000287646800006-
dc.identifier.f10009872956-

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