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Article: Wnt regulation of planar cell polarity (PCP)

TitleWnt regulation of planar cell polarity (PCP)
Authors
KeywordsAnimals
Cell Movement
*Cell Polarity
Drosophila/embryology/genetics/metabolism
Drosophila Proteins/genetics/metabolism
Embryonic Development
*Gene Expression Regulation, Developmental
Hair/metabolism
Mice
Nerve Tissue Proteins/genetics/metabolism
Neural Tube Defects/metabolism/pathology
Receptor Protein-Tyrosine Kinases/genetics/metabolism
Wing/cytology/metabolism
Wnt Proteins/genetics/metabolism
*Wnt Signaling Pathway
Zebrafish/embryology/genetics/metabolism
Zebrafish Proteins/genetics/metabolism
Issue Date2012
Citation
Current Topics in Developmental Biology, 2012, v. 101, p. 263-295 How to Cite?
AbstractPlanar cell polarity (PCP), a process controlling coordinated, uniformly polarized cellular behaviors in a field of cells, has been identified to be critically required for many fundamental developmental processes. However, a global directional cue that establishes PCP in a three-dimensional tissue or organ with respect to the body axes remains elusive. In vertebrate, while Wnt-secreted signaling molecules have been implicated in regulating PCP in a beta-catenin-independent manner, whether they function permissively or act as a global cue to convey directional information is not clearly defined. In addition, the underlying molecular mechanism by which Wnt signal is transduced to core PCP proteins is largely unknown. In this chapter, I review the roles of Wnt signaling in regulating PCP during vertebrate development and update our knowledge of its regulatory mechanism.
Persistent Identifierhttp://hdl.handle.net/10722/208443
ISSN

 

DC FieldValueLanguage
dc.contributor.authorGao, Ben_US
dc.date.accessioned2015-03-11T03:01:03Z-
dc.date.available2015-03-11T03:01:03Z-
dc.date.issued2012en_US
dc.identifier.citationCurrent Topics in Developmental Biology, 2012, v. 101, p. 263-295en_US
dc.identifier.issn1557-8933en_US
dc.identifier.urihttp://hdl.handle.net/10722/208443-
dc.description.abstractPlanar cell polarity (PCP), a process controlling coordinated, uniformly polarized cellular behaviors in a field of cells, has been identified to be critically required for many fundamental developmental processes. However, a global directional cue that establishes PCP in a three-dimensional tissue or organ with respect to the body axes remains elusive. In vertebrate, while Wnt-secreted signaling molecules have been implicated in regulating PCP in a beta-catenin-independent manner, whether they function permissively or act as a global cue to convey directional information is not clearly defined. In addition, the underlying molecular mechanism by which Wnt signal is transduced to core PCP proteins is largely unknown. In this chapter, I review the roles of Wnt signaling in regulating PCP during vertebrate development and update our knowledge of its regulatory mechanism.en_US
dc.languageengen_US
dc.relation.ispartofCurrent Topics in Developmental Biologyen_US
dc.subjectAnimalsen_US
dc.subjectCell Movementen_US
dc.subject*Cell Polarityen_US
dc.subjectDrosophila/embryology/genetics/metabolismen_US
dc.subjectDrosophila Proteins/genetics/metabolismen_US
dc.subjectEmbryonic Developmenten_US
dc.subject*Gene Expression Regulation, Developmentalen_US
dc.subjectHair/metabolismen_US
dc.subjectMiceen_US
dc.subjectNerve Tissue Proteins/genetics/metabolismen_US
dc.subjectNeural Tube Defects/metabolism/pathologyen_US
dc.subjectReceptor Protein-Tyrosine Kinases/genetics/metabolismen_US
dc.subjectWing/cytology/metabolismen_US
dc.subjectWnt Proteins/genetics/metabolismen_US
dc.subject*Wnt Signaling Pathwayen_US
dc.subjectZebrafish/embryology/genetics/metabolismen_US
dc.subjectZebrafish Proteins/genetics/metabolismen_US
dc.titleWnt regulation of planar cell polarity (PCP)en_US
dc.typeArticleen_US
dc.identifier.emailGao, B: gaobo@hku.hken_US
dc.identifier.authorityGao, B=rp02012en_US
dc.identifier.doi10.1016/B978-0-12-394592-1.00008-9en_US
dc.identifier.pmid23140633-
dc.identifier.scopuseid_2-s2.0-84868665485-
dc.identifier.volume101en_US
dc.identifier.spage263en_US
dc.identifier.epage295en_US

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