File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Planar cell polarity in vertebrate limb morphogenesis

TitlePlanar cell polarity in vertebrate limb morphogenesis
Authors
KeywordsAnimals
Cell Polarity/*genetics
Extremities/*growth & development
Models, Theoretical
Morphogenesis/*genetics
Signal Transduction
Vertebrates/growth & development
Wnt Proteins/*genetics
Issue Date2013
Citation
Current Opinion in Genetics and Development, 2013, v. 23 n. 4, p. 438-444 How to Cite?
AbstractStudies of the vertebrate limb development have contributed significantly to understanding the fundamental mechanisms underlying growth, patterning, and morphogenesis of a complex multicellular organism. In the limb, well-defined signaling centers interact to coordinate limb growth and patterning along the three axes. Recent analyses of live imaging and mathematical modeling have provided evidence that polarized cell behaviors governed by morphogen gradients play an important role in shaping the limb bud. Furthermore, the Wnt/planar cell polarity (PCP) pathway that controls uniformly polarized cell behaviors in a field of cells has emerged to be critical for directional morphogenesis in the developing limb. Directional information coded in the morphogen gradient may be interpreted by responding cells through regulating the activities of PCP components in a Wnt morphogen dose-dependent manner.
Persistent Identifierhttp://hdl.handle.net/10722/208442
ISSN
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGao, Ben_US
dc.contributor.authorYang, Yen_US
dc.date.accessioned2015-03-11T03:01:02Z-
dc.date.available2015-03-11T03:01:02Z-
dc.date.issued2013en_US
dc.identifier.citationCurrent Opinion in Genetics and Development, 2013, v. 23 n. 4, p. 438-444en_US
dc.identifier.issn1879-0380en_US
dc.identifier.urihttp://hdl.handle.net/10722/208442-
dc.description.abstractStudies of the vertebrate limb development have contributed significantly to understanding the fundamental mechanisms underlying growth, patterning, and morphogenesis of a complex multicellular organism. In the limb, well-defined signaling centers interact to coordinate limb growth and patterning along the three axes. Recent analyses of live imaging and mathematical modeling have provided evidence that polarized cell behaviors governed by morphogen gradients play an important role in shaping the limb bud. Furthermore, the Wnt/planar cell polarity (PCP) pathway that controls uniformly polarized cell behaviors in a field of cells has emerged to be critical for directional morphogenesis in the developing limb. Directional information coded in the morphogen gradient may be interpreted by responding cells through regulating the activities of PCP components in a Wnt morphogen dose-dependent manner.en_US
dc.languageengen_US
dc.relation.ispartofCurrent Opinion in Genetics and Developmenten_US
dc.subjectAnimalsen_US
dc.subjectCell Polarity/*geneticsen_US
dc.subjectExtremities/*growth & developmenten_US
dc.subjectModels, Theoreticalen_US
dc.subjectMorphogenesis/*geneticsen_US
dc.subjectSignal Transductionen_US
dc.subjectVertebrates/growth & developmenten_US
dc.subjectWnt Proteins/*geneticsen_US
dc.titlePlanar cell polarity in vertebrate limb morphogenesisen_US
dc.typeArticleen_US
dc.identifier.emailGao, B: gaobo@hku.hken_US
dc.identifier.authorityGao, B=rp02012en_US
dc.identifier.doi10.1016/j.gde.2013.05.003en_US
dc.identifier.pmid23747034-
dc.identifier.pmcid3759593-
dc.identifier.scopuseid_2-s2.0-84883455409-
dc.identifier.volume23en_US
dc.identifier.issue4en_US
dc.identifier.spage438en_US
dc.identifier.epage444en_US
dc.identifier.isiWOS:000324362900011-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats