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Article: IHH and FGF8 coregulate elongation of digit primordia

TitleIHH and FGF8 coregulate elongation of digit primordia
Authors
KeywordsAnimals
Cartilage/embryology/metabolism
Cell Differentiation/genetics/physiology
Chick Embryo
Chickens
Chondrogenesis/genetics/physiology
Fibroblast Growth Factor 8/genetics/metabolism/*physiology
Gene Expression Regulation, Developmental
Hedgehog Proteins/genetics/metabolism/*physiology
Humans
In Situ Hybridization
Limb Buds/cytology/*embryology/metabolism
Issue Date2007
Citation
Biochemical and Biophysical Research Communications, 2007, v. 363 n. 3, p. 513-518 How to Cite?
AbstractIn the developing limb bud, digit pattern arises from anterior-posterior (A-P) positional information which is provided by the concentration gradient of SHH. However, the mechanisms of translating early asymmetry into morphological form are still unclear. Here, we examined the ability of IHH and FGF8 signaling to regulate digital chondrogenesis, by implanting protein-loaded beads in the interdigital space singly and in combination. We found that IHH protein induced an elongated digit and that FGF8 protein blocked the terminal phalange formation. Molecular marker analysis showed that IHH expanded Sox9 expression in mesenchymal cells possibly through up-regulated FGF8 expression. Application of both IHH and FGF8 protein induced a large terminal phalange. These results suggest that both enhanced IHH and FGF8 signaling are required for the development of additional cartilage element in limbs. IHH and FGF8 maybe play different roles and act synergistically to promote chondrogenesis during digit primordia elongation.
Persistent Identifierhttp://hdl.handle.net/10722/208436
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Jen_US
dc.contributor.authorMeng, Jen_US
dc.contributor.authorGuo, Sen_US
dc.contributor.authorGao, Ben_US
dc.contributor.authorMa, Gen_US
dc.contributor.authorZhu, Xen_US
dc.contributor.authorHu, Jen_US
dc.contributor.authorXiao, Yen_US
dc.contributor.authorLin, Cen_US
dc.contributor.authorWang, Hen_US
dc.contributor.authorDing, Len_US
dc.contributor.authorFeng, Gen_US
dc.contributor.authorGuo, Xen_US
dc.contributor.authorHe, Len_US
dc.date.accessioned2015-03-11T03:00:55Z-
dc.date.available2015-03-11T03:00:55Z-
dc.date.issued2007en_US
dc.identifier.citationBiochemical and Biophysical Research Communications, 2007, v. 363 n. 3, p. 513-518en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/208436-
dc.description.abstractIn the developing limb bud, digit pattern arises from anterior-posterior (A-P) positional information which is provided by the concentration gradient of SHH. However, the mechanisms of translating early asymmetry into morphological form are still unclear. Here, we examined the ability of IHH and FGF8 signaling to regulate digital chondrogenesis, by implanting protein-loaded beads in the interdigital space singly and in combination. We found that IHH protein induced an elongated digit and that FGF8 protein blocked the terminal phalange formation. Molecular marker analysis showed that IHH expanded Sox9 expression in mesenchymal cells possibly through up-regulated FGF8 expression. Application of both IHH and FGF8 protein induced a large terminal phalange. These results suggest that both enhanced IHH and FGF8 signaling are required for the development of additional cartilage element in limbs. IHH and FGF8 maybe play different roles and act synergistically to promote chondrogenesis during digit primordia elongation.en_US
dc.languageengen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subjectAnimalsen_US
dc.subjectCartilage/embryology/metabolismen_US
dc.subjectCell Differentiation/genetics/physiologyen_US
dc.subjectChick Embryoen_US
dc.subjectChickensen_US
dc.subjectChondrogenesis/genetics/physiologyen_US
dc.subjectFibroblast Growth Factor 8/genetics/metabolism/*physiologyen_US
dc.subjectGene Expression Regulation, Developmentalen_US
dc.subjectHedgehog Proteins/genetics/metabolism/*physiologyen_US
dc.subjectHumansen_US
dc.subjectIn Situ Hybridizationen_US
dc.subjectLimb Buds/cytology/*embryology/metabolismen_US
dc.titleIHH and FGF8 coregulate elongation of digit primordiaen_US
dc.typeArticleen_US
dc.identifier.emailGao, B: gaobo@hku.hken_US
dc.identifier.authorityGao, B=rp02012en_US
dc.identifier.doi10.1016/j.bbrc.2007.08.198en_US
dc.identifier.pmid17889828-
dc.identifier.scopuseid_2-s2.0-34848904485-
dc.identifier.volume363en_US
dc.identifier.issue3en_US
dc.identifier.spage513en_US
dc.identifier.epage518en_US
dc.identifier.isiWOS:000250359400011-

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