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Conference Paper: Cognitive function in systemic lupus erythematosus patients with past history of neuropsychiatric manifestations: a longitudinal study

TitleCognitive function in systemic lupus erythematosus patients with past history of neuropsychiatric manifestations: a longitudinal study
Authors
KeywordsMedical sciences
Rheumatology
Issue Date2014
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2326-5205
Citation
The 2014 Annual Meeting of the American College of Rheumatology (ACR/ARHP), Boston, MA., 14-19 November 2014. In Arthritis & Rheumatology, 2014, v. 66 n. S10, p. S1162, abstract 2654 How to Cite?
AbstractBACKGROUND/PURPOSE: Cognitive impairment is commonly reported in patients with systemic lupus erythematosus (SLE) and its associations with neuropsychiatric involvement (NPSLE) and psychiatric factors have been inconsistently reported in the literature. OBJECTIVE: To evaluate full neurocognitive function in relation to psychiatric factors including anxiety and depression in NPSLE patients longitudinally compared to matched controls. METHODS: Cognitive symptom inventory (CSI) was used to measure perceived cognitive impairment whereas full neurocognitive battery that covered 8 cognitive domains were performed by trained psychologist at 2 time-points 12 months apart. Depressive and anxiety symptoms were measured by HADS. RESULTS: 18 NPSLE and 18 non-NPSLE patients matched to age, sex and disease duration as well as 16 age- and sex- matched healthy subjects were recruited. NPSLE patients consistently reported more cognitive impairment and anxiety symptoms than non-NPSLE patients over both time-points. NPSLE patients had worse performance on 3 memory tests whereas non-NPSLE patients only showed significantly lower AVLT recognition compared with healthy subjects by post-hoc analysis. Applying age- and education- adjusted Chinese norms, NPSLE patients had significantly worse performance than non-NPSLE patients over 5 cognitive domains including simple and complex attention, memory, reasoning and visuospatial function which remained significant when adjusted for HADS-A. Anxiety contributed only to AVLT delay recall in regression analysis. Longitudinal analysis revealed improvement in some cognitive tests by non-NPSLE patients at re-evaluation whereas NPSLE patients did not show any difference in serial test performance. CONCLUSION: Compared to non-NPSLE patients, NPSLE patients reported more cognitive and anxiety symptoms and had significantly worse cognitive functions involving simple and complex attention, memory, reasoning and visuospatial domains. Unlike non-NPSLE patients, they failed to demonstrate learning effect upon re-evaluation over 12 months.
DescriptionThis free journal suppl. entitled: Special Issue: 2014 ACR/ARHP Annual Meeting Abstract Supplement
Persistent Identifierhttp://hdl.handle.net/10722/208307
ISSN
2015 Impact Factor: 6.009

 

DC FieldValueLanguage
dc.contributor.authorGao, Y-
dc.contributor.authorLo, Y-
dc.contributor.authorWan, JHY-
dc.contributor.authorLau, EYY-
dc.contributor.authorMok, MY-
dc.date.accessioned2015-02-23T08:22:03Z-
dc.date.available2015-02-23T08:22:03Z-
dc.date.issued2014-
dc.identifier.citationThe 2014 Annual Meeting of the American College of Rheumatology (ACR/ARHP), Boston, MA., 14-19 November 2014. In Arthritis & Rheumatology, 2014, v. 66 n. S10, p. S1162, abstract 2654-
dc.identifier.issn2326-5191-
dc.identifier.urihttp://hdl.handle.net/10722/208307-
dc.descriptionThis free journal suppl. entitled: Special Issue: 2014 ACR/ARHP Annual Meeting Abstract Supplement-
dc.description.abstractBACKGROUND/PURPOSE: Cognitive impairment is commonly reported in patients with systemic lupus erythematosus (SLE) and its associations with neuropsychiatric involvement (NPSLE) and psychiatric factors have been inconsistently reported in the literature. OBJECTIVE: To evaluate full neurocognitive function in relation to psychiatric factors including anxiety and depression in NPSLE patients longitudinally compared to matched controls. METHODS: Cognitive symptom inventory (CSI) was used to measure perceived cognitive impairment whereas full neurocognitive battery that covered 8 cognitive domains were performed by trained psychologist at 2 time-points 12 months apart. Depressive and anxiety symptoms were measured by HADS. RESULTS: 18 NPSLE and 18 non-NPSLE patients matched to age, sex and disease duration as well as 16 age- and sex- matched healthy subjects were recruited. NPSLE patients consistently reported more cognitive impairment and anxiety symptoms than non-NPSLE patients over both time-points. NPSLE patients had worse performance on 3 memory tests whereas non-NPSLE patients only showed significantly lower AVLT recognition compared with healthy subjects by post-hoc analysis. Applying age- and education- adjusted Chinese norms, NPSLE patients had significantly worse performance than non-NPSLE patients over 5 cognitive domains including simple and complex attention, memory, reasoning and visuospatial function which remained significant when adjusted for HADS-A. Anxiety contributed only to AVLT delay recall in regression analysis. Longitudinal analysis revealed improvement in some cognitive tests by non-NPSLE patients at re-evaluation whereas NPSLE patients did not show any difference in serial test performance. CONCLUSION: Compared to non-NPSLE patients, NPSLE patients reported more cognitive and anxiety symptoms and had significantly worse cognitive functions involving simple and complex attention, memory, reasoning and visuospatial domains. Unlike non-NPSLE patients, they failed to demonstrate learning effect upon re-evaluation over 12 months.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2326-5205-
dc.relation.ispartofArthritis & Rheumatology (Hoboken)-
dc.rightsArthritis & Rheumatology (Hoboken). Copyright © John Wiley & Sons, Inc..-
dc.subjectMedical sciences-
dc.subjectRheumatology-
dc.titleCognitive function in systemic lupus erythematosus patients with past history of neuropsychiatric manifestations: a longitudinal study-
dc.typeConference_Paper-
dc.identifier.emailLo, Y: yloa@hkucc.hku.hk-
dc.identifier.emailLau, EYY: eyylau@hku.hk-
dc.identifier.emailMok, MY: temy@hkucc.hku.hk-
dc.identifier.authorityLau, EYY=rp00634-
dc.identifier.authorityMok, MY=rp00490-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/art.38914-
dc.identifier.hkuros242357-
dc.identifier.volume66-
dc.identifier.issueS10-
dc.identifier.spageS1162, abstract 2654-
dc.identifier.epageS1162, abstract 2654-
dc.publisher.placeUnited States-

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