granted patent: Cell-Matrix Microspheres, Methods for Preparation and Applications

TitleCell-Matrix Microspheres, Methods for Preparation and Applications
Granted PatentUS 20140170745
Granted Date2014-06-19
Priority Date2014-02-18 US 12/4183260
2007-05-18 US 11/750863
2006-05-19 US 11/801975P
Inventors
Issue Date2014
Citation
US Patent US 20140170745. Washington, DC: US Patent and Trademark Office (USPTO), 2014 How to Cite?
AbstractA method has been developed to produce stable cell-matrix microspheres with up to 100% encapsulation efficiency and high cell viability, using matrix or biomaterial systems with poor shape and mechanical stability for applications including cell therapeutics via microinjection or surgical implantation, 3D culture for in vitro expansion without repeated cell splitting using enzymatic digestion or mechanical dissociation and for enhanced production of therapeutic biomolecules, and in vitro modeling for morphogenesis studies. The modified droplet generation method is simple and scalable and enables the production of cell-matrix microspheres when the matrix or biomaterial system used has low concentration, with slow phase transition, with poor shape and mechanical stability.
Persistent Identifierhttp://hdl.handle.net/10722/208093

 

DC FieldValueLanguage
dc.date.accessioned2015-02-11T01:42:41Z-
dc.date.available2015-02-11T01:42:41Z-
dc.date.issued2014en_US
dc.identifier.citationUS Patent US 20140170745. Washington, DC: US Patent and Trademark Office (USPTO), 2014en_US
dc.identifier.urihttp://hdl.handle.net/10722/208093-
dc.description.abstractA method has been developed to produce stable cell-matrix microspheres with up to 100% encapsulation efficiency and high cell viability, using matrix or biomaterial systems with poor shape and mechanical stability for applications including cell therapeutics via microinjection or surgical implantation, 3D culture for in vitro expansion without repeated cell splitting using enzymatic digestion or mechanical dissociation and for enhanced production of therapeutic biomolecules, and in vitro modeling for morphogenesis studies. The modified droplet generation method is simple and scalable and enables the production of cell-matrix microspheres when the matrix or biomaterial system used has low concentration, with slow phase transition, with poor shape and mechanical stability.en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License for public patent documentsen_US
dc.titleCell-Matrix Microspheres, Methods for Preparation and Applicationsen_US
dc.typePatenten_US
dc.identifier.authorityCHAN BARBARA PUI=rp00087en_US
dc.identifier.authorityCHAN GODFREY CHI-FUNG=rp00431en_US
dc.identifier.authorityCHEUNG PIK TO=rp00351en_US
dc.identifier.authorityCHEAH SONG-ENG KATHRYN=rp00342en_US
dc.identifier.authorityCHAN DANNY=rp00540en_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorChan, BPen_US
dc.contributor.inventorChan, GCFen_US
dc.contributor.inventorWong, HLen_US
dc.contributor.inventorCheung, PTen_US
dc.contributor.inventorCheah, KSEen_US
dc.contributor.inventorChan, Den_US
patents.identifier.applicationUS 12/4183260en_US
patents.identifier.grantedUS 20140170745en_US
patents.description.assigneeUNIV HONG KONG [CN]en_US
patents.description.countryUnited States of Americaen_US
patents.date.granted2014-06-19en_US
patents.identifier.hkutechidME-2006-00213-1en_US
patents.date.application2014-02-18en_US
patents.date.priority2014-02-18 US 12/4183260en_US
patents.date.priority2007-05-18 US 11/750863en_US
patents.date.priority2006-05-19 US 11/801975Pen_US
patents.description.ccusen_US
patents.relation.familyCN 101448527 (A) 2009-06-03en_US
patents.relation.familyEP 2021035 (A2) 2009-02-11en_US
patents.relation.familyUS 2008031858 (A1) 2008-02-07en_US
patents.relation.familyU S8679809 (B2) 2014-03-25en_US
patents.relation.familyUS 2012148537 (A1) 2012-06-14en_US
patents.relation.familyWO 2008075206 (A2) 2008-06-26en_US
patents.description.kindA1en_US
patents.typePatent_granteden_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats