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Article: Increase of proenkepahlin mRNA and enkephalin content of rat striatum after daily injection of haloperidol for 2 to 3 weeks

TitleIncrease of proenkepahlin mRNA and enkephalin content of rat striatum after daily injection of haloperidol for 2 to 3 weeks
Authors
Issue Date1983
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings of the National Academy of Sciences, 1983, v. 80 n. 12, p. 3841-3844 How to Cite?
AbstractProenkephalin mRNA has been detected in striatum, hypothalamus, cortex, cerebellum, hippocampus, midbrain, and brain stem of rat by RNA ('Northern') blot analysis using a 918-base-pair DNA hybridization probe complementary to proenkephalin mRNA [Comb, M., Seeburg, P. H., Adelman, J., Eiden, L. & Herbert, E. (1982) Nature (London) 295, 663-666]. The size of the mRNA species in all brain regions is approximately 1,400 bases, and it was found to be comparable with that of bovine adrenal medulla and human pheochromocytoma. The data were quantified by densitometric scanning of the autoradiograms: the area under the peak is proportional to the amount of standard proenkephalin mRNA from bovine adrenal medulla. The relative content of proenkephalin mRNA in the various brain regions correlates generally with the content of [Met5]enkephalin-like immunoactivity of these regions. Rats receiving daily intraperitoneal injection of haloperidol (1 or 2 mg/kg) show a fourfold increase of proenkephalin mRNA content in striatum but not other brain regions. In agreement with previous reports, [Met5]enkephalin-like immunoactivity increased twofold in striatum.
Persistent Identifierhttp://hdl.handle.net/10722/207989
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorTang, F-
dc.contributor.authorCosta, E-
dc.contributor.authorSchwartz, JP-
dc.date.accessioned2015-02-05T09:35:46Z-
dc.date.available2015-02-05T09:35:46Z-
dc.date.issued1983-
dc.identifier.citationProceedings of the National Academy of Sciences, 1983, v. 80 n. 12, p. 3841-3844-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10722/207989-
dc.description.abstractProenkephalin mRNA has been detected in striatum, hypothalamus, cortex, cerebellum, hippocampus, midbrain, and brain stem of rat by RNA ('Northern') blot analysis using a 918-base-pair DNA hybridization probe complementary to proenkephalin mRNA [Comb, M., Seeburg, P. H., Adelman, J., Eiden, L. & Herbert, E. (1982) Nature (London) 295, 663-666]. The size of the mRNA species in all brain regions is approximately 1,400 bases, and it was found to be comparable with that of bovine adrenal medulla and human pheochromocytoma. The data were quantified by densitometric scanning of the autoradiograms: the area under the peak is proportional to the amount of standard proenkephalin mRNA from bovine adrenal medulla. The relative content of proenkephalin mRNA in the various brain regions correlates generally with the content of [Met5]enkephalin-like immunoactivity of these regions. Rats receiving daily intraperitoneal injection of haloperidol (1 or 2 mg/kg) show a fourfold increase of proenkephalin mRNA content in striatum but not other brain regions. In agreement with previous reports, [Met5]enkephalin-like immunoactivity increased twofold in striatum.-
dc.languageeng-
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org-
dc.relation.ispartofProceedings of the National Academy of Sciences-
dc.titleIncrease of proenkepahlin mRNA and enkephalin content of rat striatum after daily injection of haloperidol for 2 to 3 weeksen_US
dc.typeArticleen_US
dc.identifier.emailTang, F: ftang@hkucc.hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid6190182-
dc.identifier.pmcidPMC394148-
dc.identifier.volume80-
dc.identifier.issue12-
dc.identifier.spage3841-
dc.identifier.epage3844-
dc.publisher.placeUnited States-

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