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Article: Peritoneal drainage does not stabilize extremely low birth weight infants with perforated bowe: data from the NET trial

TitlePeritoneal drainage does not stabilize extremely low birth weight infants with perforated bowe: data from the NET trial
Authors
Issue Date2010
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
Citation
Journal of Pediatric Surgery, 2010, v. 45 n. 2, p. 324-329 How to Cite?
AbstractINTRODUCTION: Proponents of peritoneal drainage (PD) hypothesize that it allows stabilization before laparotomy. We examined this hypothesis by comparing clinical status before and after either PD or primary laparotomy (LAP). METHODS: In an ethically approved, international, prospective randomized controlled trial (2002-2006), extremely low birth weight (<1000 g) infants with pneumoperitoneum received primary PD (n = 35) or LAP (n = 34). Physiologic data were collected prospectively and organ failure scores calculated and compared between preprocedure and day 1 after procedure. Data, expressed as mean +/- SD or median (range), were analyzed using appropriate statistical tests. RESULTS: There was no postprocedure improvement in either PD or LAP group comparing heart rate (PD, P = 1.0; LAP, P = .6), blood pressure (PD, P = .6; LAP, P = .8), inotrope requirement (PD, P = .2; LAP, P = .3), or Arterial partial pressure of oxygen/fraction of inspired oxygen ratio (PD, P = .1; LAP, P = .5). Infants managed with PD had a worsening cardiovascular status (P = .05). There were no differences in total organ failure score in either group (PD, P = .5; LAP, P = 1). Only 4 infants survived with PD alone with no difference between preprocedure and postprocedure organ failure score (P = .4). CONCLUSIONS: Peritoneal drainage does not immediately improve clinical status in extremely low birth weight infants with bowel perforation. The use of PD as a stabilizing or temporizing measure is not supported by these results. Copyright 2010 Elsevier Inc. All rights reserved.
DescriptionPKH Tam (Queen Mary Hospital, Hong Kong) is one of the memebers in 'The NET Trial Group'
Persistent Identifierhttp://hdl.handle.net/10722/207946
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.802

 

DC FieldValueLanguage
dc.contributor.authorRees, CM-
dc.contributor.authorEaton, S-
dc.contributor.authorKhoo, AK-
dc.contributor.authorKiely, EM-
dc.contributor.authorMembers of the NET Trial Group-
dc.contributor.authorPierro, A-
dc.contributor.authorTam, PKH-
dc.date.accessioned2015-01-27T02:58:58Z-
dc.date.available2015-01-27T02:58:58Z-
dc.date.issued2010-
dc.identifier.citationJournal of Pediatric Surgery, 2010, v. 45 n. 2, p. 324-329-
dc.identifier.issn0022-3468-
dc.identifier.urihttp://hdl.handle.net/10722/207946-
dc.descriptionPKH Tam (Queen Mary Hospital, Hong Kong) is one of the memebers in 'The NET Trial Group'-
dc.description.abstractINTRODUCTION: Proponents of peritoneal drainage (PD) hypothesize that it allows stabilization before laparotomy. We examined this hypothesis by comparing clinical status before and after either PD or primary laparotomy (LAP). METHODS: In an ethically approved, international, prospective randomized controlled trial (2002-2006), extremely low birth weight (<1000 g) infants with pneumoperitoneum received primary PD (n = 35) or LAP (n = 34). Physiologic data were collected prospectively and organ failure scores calculated and compared between preprocedure and day 1 after procedure. Data, expressed as mean +/- SD or median (range), were analyzed using appropriate statistical tests. RESULTS: There was no postprocedure improvement in either PD or LAP group comparing heart rate (PD, P = 1.0; LAP, P = .6), blood pressure (PD, P = .6; LAP, P = .8), inotrope requirement (PD, P = .2; LAP, P = .3), or Arterial partial pressure of oxygen/fraction of inspired oxygen ratio (PD, P = .1; LAP, P = .5). Infants managed with PD had a worsening cardiovascular status (P = .05). There were no differences in total organ failure score in either group (PD, P = .5; LAP, P = 1). Only 4 infants survived with PD alone with no difference between preprocedure and postprocedure organ failure score (P = .4). CONCLUSIONS: Peritoneal drainage does not immediately improve clinical status in extremely low birth weight infants with bowel perforation. The use of PD as a stabilizing or temporizing measure is not supported by these results. Copyright 2010 Elsevier Inc. All rights reserved.-
dc.languageeng-
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg-
dc.relation.ispartofJournal of Pediatric Surgery-
dc.subject.meshDrainage - methods-
dc.subject.meshEnterocolitis, Necrotizing - surgery-
dc.subject.meshInfant, Extremely Low Birth Weight - physiology-
dc.subject.meshIntestinal Perforation - surgery-
dc.subject.meshLaparotomy - methods-
dc.titlePeritoneal drainage does not stabilize extremely low birth weight infants with perforated bowe: data from the NET trialen_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jpedsurg.2009.10.066-
dc.identifier.pmid20152345-
dc.identifier.hkuros170756-
dc.identifier.volume45-
dc.identifier.issue2-
dc.identifier.spage324-
dc.identifier.epage329-
dc.publisher.placeUnited States-

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