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Article: Human H7N9 and H5N1 influenza viruses differ in induction of cytokines and tissue tropism.

TitleHuman H7N9 and H5N1 influenza viruses differ in induction of cytokines and tissue tropism.
Authors
Issue Date2014
Citation
Journal of Virology, 2014, v. 88 n. 22, p. 12982-12991 How to Cite?
AbstractSince emerging in 2013, the avian-origin H7N9 influenza viruses have resulted in over 400 human infections, leading to 115 deaths to date. Although the epidemiology differs from human highly pathogenic avian H5N1 influenza virus infections, there is a similar rapid progression to acute respiratory distress syndrome. The aim of these studies was to compare the pathological and immunological characteristics of a panel of human H7N9 and H5N1 viruses in vitro and in vivo. Although there were similarities between particular H5N1 and H7N9 viruses, including association between lethal disease and spread to the alveolar spaces and kidney, there were also strain-specific differences. Both H5N1 and H7N9 viruses are capable of causing lethal infections, with mortality correlating most strongly with wider distribution of viral antigen in the lungs, rather than with traditional measures of virus titer and host responses. Strain-specific differences included hypercytokinemia in H5N1 infections that was not seen with the H7N9 infections regardless of lethality. Conversely, H7N9 viruses showed a greater tropism for respiratory epithelium covering nasal passages and nasopharynx-associated lymphoid tissue than H5N1 viruses, which may explain the enhanced transmission in ferret models. Overall, these studies highlight some distinctive properties of H5N1 and H7N9 viruses in different in vitro and in vivo models.
Persistent Identifierhttp://hdl.handle.net/10722/207839
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorMeliopoulos, VAen_US
dc.contributor.authorKarlsson, EAen_US
dc.contributor.authorKercher, Len_US
dc.contributor.authorCline, Ten_US
dc.contributor.authorFreiden, Pen_US
dc.contributor.authorDuan, Sen_US
dc.contributor.authorVogel, Pen_US
dc.contributor.authorWebby, RJen_US
dc.contributor.authorGuan, Yen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorThomas, PGen_US
dc.contributor.authorSchultz-Cherry, Sen_US
dc.date.accessioned2015-01-19T11:23:03Z-
dc.date.available2015-01-19T11:23:03Z-
dc.date.issued2014en_US
dc.identifier.citationJournal of Virology, 2014, v. 88 n. 22, p. 12982-12991en_US
dc.identifier.urihttp://hdl.handle.net/10722/207839-
dc.description.abstractSince emerging in 2013, the avian-origin H7N9 influenza viruses have resulted in over 400 human infections, leading to 115 deaths to date. Although the epidemiology differs from human highly pathogenic avian H5N1 influenza virus infections, there is a similar rapid progression to acute respiratory distress syndrome. The aim of these studies was to compare the pathological and immunological characteristics of a panel of human H7N9 and H5N1 viruses in vitro and in vivo. Although there were similarities between particular H5N1 and H7N9 viruses, including association between lethal disease and spread to the alveolar spaces and kidney, there were also strain-specific differences. Both H5N1 and H7N9 viruses are capable of causing lethal infections, with mortality correlating most strongly with wider distribution of viral antigen in the lungs, rather than with traditional measures of virus titer and host responses. Strain-specific differences included hypercytokinemia in H5N1 infections that was not seen with the H7N9 infections regardless of lethality. Conversely, H7N9 viruses showed a greater tropism for respiratory epithelium covering nasal passages and nasopharynx-associated lymphoid tissue than H5N1 viruses, which may explain the enhanced transmission in ferret models. Overall, these studies highlight some distinctive properties of H5N1 and H7N9 viruses in different in vitro and in vivo models.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Virologyen_US
dc.titleHuman H7N9 and H5N1 influenza viruses differ in induction of cytokines and tissue tropism.en_US
dc.typeArticleen_US
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.authorityGuan, Y=rp00397en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.identifier.doi10.1128/JVI.01571-14en_US
dc.identifier.pmcidPMC4249090-
dc.identifier.hkuros242086en_US
dc.identifier.volume88en_US
dc.identifier.issue22en_US
dc.identifier.spage12982en_US
dc.identifier.epage91en_US

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