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Article: Association of myocardial dysfunction with vitamin D deficiency in patients with type 2 diabetes mellitus

TitleAssociation of myocardial dysfunction with vitamin D deficiency in patients with type 2 diabetes mellitus
Authors
KeywordsDiabetes Mellitus
Myocardial dysfunction
Vitamin D deficiency
Issue Date2014
Citation
Journal of Diabetes and its Complications, 2014, v. 28 n. 3, p. 286-290 How to Cite?
AbstractAIMS: The underlying mechanism of myocardial dysfunction in patients with type 2 diabetes mellitus (T2DM) is unclear. Nonetheless recent studies have revealed that vitamin D (vit-D) deficiency, which is prevalent in such patients, is associated with adverse cardiovascular events. We hypothesized that vit-D deficiency in patients with T2DM may contribute to left ventricular (LV) dysfunction. METHODS: We studied 95 patients (62+/-9years, 58% female) with T2DM. None had any history of coronary artery disease and all underwent detailed transthoracic echocardiography, including speckle tracking derived strains. Plasma level of 25-hydoxyvitamin D (25-OHD) was also measured. RESULTS: Vitamin D deficiency was evident in 60 (63%) patients. The LV dimension, LVEF and diastolic grade were similar between those with and without deficiency although an impaired global longitudinal strain was present in the former. Importantly, 25-OHD was negatively associated with global longitudinal strain (R = -0.21, P=0.046) and positively with body-mass index (BMI; R=0.26, P=0.01). Both vit-D deficiency and BMI were associated with impaired global LV longitudinal strain, independent of T2DM disease characteristics. CONCLUSIONS: In patients with T2DM and no history of coronary artery disease, vit-D deficiency is independently associated with impaired global longitudinal strain. This suggests that vit-D deficiency may contribute to the development of myocardial dysfunction in these patients.
Persistent Identifierhttp://hdl.handle.net/10722/207704
ISSN
2015 Impact Factor: 2.955
2015 SCImago Journal Rankings: 1.632

 

DC FieldValueLanguage
dc.contributor.authorChen, Yen_US
dc.contributor.authorZhao, CTen_US
dc.contributor.authorZhen, Zen_US
dc.contributor.authorWong, Aen_US
dc.contributor.authorTse, HFen_US
dc.contributor.authorYiu, KHen_US
dc.date.accessioned2015-01-19T04:20:43Z-
dc.date.available2015-01-19T04:20:43Z-
dc.date.issued2014en_US
dc.identifier.citationJournal of Diabetes and its Complications, 2014, v. 28 n. 3, p. 286-290en_US
dc.identifier.issn1056-8727en_US
dc.identifier.urihttp://hdl.handle.net/10722/207704-
dc.description.abstractAIMS: The underlying mechanism of myocardial dysfunction in patients with type 2 diabetes mellitus (T2DM) is unclear. Nonetheless recent studies have revealed that vitamin D (vit-D) deficiency, which is prevalent in such patients, is associated with adverse cardiovascular events. We hypothesized that vit-D deficiency in patients with T2DM may contribute to left ventricular (LV) dysfunction. METHODS: We studied 95 patients (62+/-9years, 58% female) with T2DM. None had any history of coronary artery disease and all underwent detailed transthoracic echocardiography, including speckle tracking derived strains. Plasma level of 25-hydoxyvitamin D (25-OHD) was also measured. RESULTS: Vitamin D deficiency was evident in 60 (63%) patients. The LV dimension, LVEF and diastolic grade were similar between those with and without deficiency although an impaired global longitudinal strain was present in the former. Importantly, 25-OHD was negatively associated with global longitudinal strain (R = -0.21, P=0.046) and positively with body-mass index (BMI; R=0.26, P=0.01). Both vit-D deficiency and BMI were associated with impaired global LV longitudinal strain, independent of T2DM disease characteristics. CONCLUSIONS: In patients with T2DM and no history of coronary artery disease, vit-D deficiency is independently associated with impaired global longitudinal strain. This suggests that vit-D deficiency may contribute to the development of myocardial dysfunction in these patients.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Diabetes and its Complicationsen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectMyocardial dysfunctionen_US
dc.subjectVitamin D deficiencyen_US
dc.titleAssociation of myocardial dysfunction with vitamin D deficiency in patients with type 2 diabetes mellitusen_US
dc.typeArticleen_US
dc.identifier.emailYiu, KH: khkyiu@hku.hken_US
dc.identifier.authorityYiu, KH=rp01490en_US
dc.identifier.doi10.1016/j.jdiacomp.2014.01.003en_US
dc.identifier.pmid24560423-
dc.identifier.hkuros253815-
dc.identifier.hkuros254841-
dc.identifier.volume28en_US
dc.identifier.issue3en_US
dc.identifier.spage286en_US
dc.identifier.epage290en_US

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