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Article: Effect of polysaccharides from Angelica sinensis on gastric ulcer healing

TitleEffect of polysaccharides from Angelica sinensis on gastric ulcer healing
Authors
KeywordsPolysaccharides
Mucus
Gastric ulcer
Angiogenesis
Angelica sinensis
Issue Date2003
Citation
Life Sciences, 2003, v. 72, n. 8, p. 925-932 How to Cite?
AbstractOur previous study showed that a crude extract from Angelica sinensis (ASCE), which mainly consisted of polysaccharides, significantly promoted migration and proliferation of normal gastric epithelial cells. These results strongly suggest that ASCE has a direct wound healing effect on gastric mucosa. However, there is no report concerning the effect of ASCE on gastric ulcer healing in animal models. In this study, we found that ASCE promoted ulcer healing. The area of the ulcer was reduced. This was accompanied with a significant increase in mucus synthesis when compared with the control. Angiogenesis was inhibited by the treatment of ASCE. Cell proliferation, ODC and EGFR protein expression was not affected in this process. Thus, the mechanism of how ASCE accelerates ulcer healing in addition to its effect on mucus synthesis remains to be investigated. © 2002 Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/207485
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056

 

DC FieldValueLanguage
dc.contributor.authorYe, Yini-
dc.contributor.authorSo, HauLeung-
dc.contributor.authorLiu, Edgar Shiu Lam-
dc.contributor.authorShin, Vivianyvonne-
dc.contributor.authorCho, Chihin-
dc.date.accessioned2014-12-31T01:01:46Z-
dc.date.available2014-12-31T01:01:46Z-
dc.date.issued2003-
dc.identifier.citationLife Sciences, 2003, v. 72, n. 8, p. 925-932-
dc.identifier.issn0024-3205-
dc.identifier.urihttp://hdl.handle.net/10722/207485-
dc.description.abstractOur previous study showed that a crude extract from Angelica sinensis (ASCE), which mainly consisted of polysaccharides, significantly promoted migration and proliferation of normal gastric epithelial cells. These results strongly suggest that ASCE has a direct wound healing effect on gastric mucosa. However, there is no report concerning the effect of ASCE on gastric ulcer healing in animal models. In this study, we found that ASCE promoted ulcer healing. The area of the ulcer was reduced. This was accompanied with a significant increase in mucus synthesis when compared with the control. Angiogenesis was inhibited by the treatment of ASCE. Cell proliferation, ODC and EGFR protein expression was not affected in this process. Thus, the mechanism of how ASCE accelerates ulcer healing in addition to its effect on mucus synthesis remains to be investigated. © 2002 Elsevier Science Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofLife Sciences-
dc.subjectPolysaccharides-
dc.subjectMucus-
dc.subjectGastric ulcer-
dc.subjectAngiogenesis-
dc.subjectAngelica sinensis-
dc.titleEffect of polysaccharides from Angelica sinensis on gastric ulcer healing-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0024-3205(02)02332-9-
dc.identifier.pmid12493573-
dc.identifier.scopuseid_2-s2.0-0037427874-
dc.identifier.hkuros76682-
dc.identifier.volume72-
dc.identifier.issue8-
dc.identifier.spage925-
dc.identifier.epage932-

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