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Article: Decolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature

TitleDecolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature
Authors
Issue Date2014
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
Citation
BMC Infectious Diseases, 2014, v. 14, article no. 514 How to Cite?
AbstractBackground: Prolonged asymptomatic carriage of vancomycin-resistant enterococci (VRE) in the gastrointestinal tract and the lack of effective decolonization regimen perpetuate the endemicity of VRE in the healthcare settings.Case presentation: We report a regimen for decolonization of gastrointestinal carriage of VRE by a combination of environmental disinfection, patient isolation, bowel preparation to wash-out the fecal bacterial population using polyethylene glycol, a five-day course of oral absorbable linezolid and non-absorbable daptomycin to suppress any remaining VRE, and subsequent oral Lactobacillus rhamnosus GG to maintain the colonization resistance in four patients, including two patients with end-stage liver cirrhosis, one patient with complication post liver transplant, and one patient with complicated infective endocarditis. All patients had clearance of VRE immediately after decolonization, and 3 of them remained VRE-free for 23 to 137 days of hospitalization, despite subsequent use of intravenous broad-spectrum antibiotics without anti-VRE activity.Conclusion: This strategy should be further studied in settings of low VRE endemicity with limited isolation facilities. © 2014 Cheng et al.; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/207253
ISSN
2015 Impact Factor: 2.69
2015 SCImago Journal Rankings: 1.510
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, VCC-
dc.contributor.authorChen, JHK-
dc.contributor.authorTai, JWM-
dc.contributor.authorWong, SCY-
dc.contributor.authorPoon, RWS-
dc.contributor.authorHung, IFN-
dc.contributor.authorTo, KKW-
dc.contributor.authorChan, JFW-
dc.contributor.authorHo, PL-
dc.contributor.authorLo, CM-
dc.contributor.authorYuen, KY-
dc.date.accessioned2014-12-19T09:35:40Z-
dc.date.available2014-12-19T09:35:40Z-
dc.date.issued2014-
dc.identifier.citationBMC Infectious Diseases, 2014, v. 14, article no. 514-
dc.identifier.issn1471-2334-
dc.identifier.urihttp://hdl.handle.net/10722/207253-
dc.description.abstractBackground: Prolonged asymptomatic carriage of vancomycin-resistant enterococci (VRE) in the gastrointestinal tract and the lack of effective decolonization regimen perpetuate the endemicity of VRE in the healthcare settings.Case presentation: We report a regimen for decolonization of gastrointestinal carriage of VRE by a combination of environmental disinfection, patient isolation, bowel preparation to wash-out the fecal bacterial population using polyethylene glycol, a five-day course of oral absorbable linezolid and non-absorbable daptomycin to suppress any remaining VRE, and subsequent oral Lactobacillus rhamnosus GG to maintain the colonization resistance in four patients, including two patients with end-stage liver cirrhosis, one patient with complication post liver transplant, and one patient with complicated infective endocarditis. All patients had clearance of VRE immediately after decolonization, and 3 of them remained VRE-free for 23 to 137 days of hospitalization, despite subsequent use of intravenous broad-spectrum antibiotics without anti-VRE activity.Conclusion: This strategy should be further studied in settings of low VRE endemicity with limited isolation facilities. © 2014 Cheng et al.; licensee BioMed Central Ltd.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/-
dc.relation.ispartofBMC Infectious Diseases-
dc.rightsBMC Infectious Diseases. Copyright © BioMed Central Ltd.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleDecolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature-
dc.typeArticle-
dc.identifier.emailCheng, VCC: vcccheng@hkucc.hku.hk-
dc.identifier.emailChen, JHK: jonchk@hku.hk-
dc.identifier.emailWong, SCY: wcy288@hku.hk-
dc.identifier.emailPoon, RWS: rosana@hkucc.hku.hk-
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hk-
dc.identifier.emailTo, KKW: kelvinto@HKUCC.hku.hk-
dc.identifier.emailChan, JFW: jfwchan@hku.hk-
dc.identifier.emailHo, PL: plho@hkucc.hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityHung, IFN=rp00508en_US
dc.identifier.authorityChan, JFW=rp01736en_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.identifier.authorityLo, CM=rp00412en_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1471-2334-14-514-
dc.identifier.pmid25248287-
dc.identifier.pmcidPMC4180964-
dc.identifier.scopuseid_2-s2.0-84907388280-
dc.identifier.hkuros241978-
dc.identifier.volume14-
dc.identifier.isiWOS:000342365500001-
dc.publisher.placeUnited Kingdom-

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