File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Distribution of MICA haplotypes in a Chinese Han population

TitleDistribution of MICA haplotypes in a Chinese Han population
Authors
KeywordsMICA
Distribution
HLA
Cantonese Han population
SBT
Issue Date2012
Citation
Human Immunology, 2012, v. 73, n. 1, p. 75-79 How to Cite?
AbstractThe MICA gene encodes nonclassical major histocompatibility complex class I molecules, centromeric to HLA-B and telomeric to HLA-DRB1. The MICA genes are polymorphic. The immune response against MICA may correlate with a decrease in graft survival after transplantation. However, data on the frequency of MICA polymorphisms in different populations are limited. In this study, we determined MICA allelic frequencies in a Han population living in Guangdong Province in south China. A total of 15 MICA alleles were identified using sequence-based typing. The most frequent allele was MICA*010 (22.22%), followed by MICA*002:01(18.56%), MICA*008:01(16.32%), and MICA*019(14.93%). The MICA null gene (MICA*Del) exhibited a frequency of 1.743% in this population. MICA and HLA, MICA-HLA-B, and MICA-HLA-A/HLA-B/HLA-DRB1 haplotype frequencies were estimated. The most common 2-, 3- and 4-locus haplotypes were HLA-B*40:01-MICA*008:01 (13.70%), HLA-A*11:01-B*40:01-MICA*008:01(8.25%), and HLA-A*33:03-B*58:01-DRB1*03:01-MICA*002:01(5.22%). A new MICA allele, MICA*061, was identified and appears to be evolutionarily related to MICA*012:01. This study provides high-resolution information on the distribution of haplotypes with MICA, HLA-A, HLA-B, and HLA-DRB1 in China. This information should help determine the mechanisms underlying diseases and allotransplant rejection associated with MICA polymorphisms in the southern Chinese Han population. © 2012 American Society for Histocompatibility and Immunogenetics.
Persistent Identifierhttp://hdl.handle.net/10722/207119
ISSN
2015 Impact Factor: 2.127
2015 SCImago Journal Rankings: 0.904

 

DC FieldValueLanguage
dc.contributor.authorXu, Xiuzhang-
dc.contributor.authorXia, Wenjie-
dc.contributor.authorTian, Linwei-
dc.contributor.authorChen, Yangkai-
dc.contributor.authorDing, Haoqiang-
dc.contributor.authorShao, Yuan-
dc.contributor.authorDeng, Jing-
dc.contributor.authorWang, Jiali-
dc.contributor.authorHuang, Yingfeng-
dc.contributor.authorSantoso, Sentot-
dc.contributor.authorFu, Yongshui-
dc.contributor.authorYe, Xin-
dc.date.accessioned2014-12-09T04:31:26Z-
dc.date.available2014-12-09T04:31:26Z-
dc.date.issued2012-
dc.identifier.citationHuman Immunology, 2012, v. 73, n. 1, p. 75-79-
dc.identifier.issn0198-8859-
dc.identifier.urihttp://hdl.handle.net/10722/207119-
dc.description.abstractThe MICA gene encodes nonclassical major histocompatibility complex class I molecules, centromeric to HLA-B and telomeric to HLA-DRB1. The MICA genes are polymorphic. The immune response against MICA may correlate with a decrease in graft survival after transplantation. However, data on the frequency of MICA polymorphisms in different populations are limited. In this study, we determined MICA allelic frequencies in a Han population living in Guangdong Province in south China. A total of 15 MICA alleles were identified using sequence-based typing. The most frequent allele was MICA*010 (22.22%), followed by MICA*002:01(18.56%), MICA*008:01(16.32%), and MICA*019(14.93%). The MICA null gene (MICA*Del) exhibited a frequency of 1.743% in this population. MICA and HLA, MICA-HLA-B, and MICA-HLA-A/HLA-B/HLA-DRB1 haplotype frequencies were estimated. The most common 2-, 3- and 4-locus haplotypes were HLA-B*40:01-MICA*008:01 (13.70%), HLA-A*11:01-B*40:01-MICA*008:01(8.25%), and HLA-A*33:03-B*58:01-DRB1*03:01-MICA*002:01(5.22%). A new MICA allele, MICA*061, was identified and appears to be evolutionarily related to MICA*012:01. This study provides high-resolution information on the distribution of haplotypes with MICA, HLA-A, HLA-B, and HLA-DRB1 in China. This information should help determine the mechanisms underlying diseases and allotransplant rejection associated with MICA polymorphisms in the southern Chinese Han population. © 2012 American Society for Histocompatibility and Immunogenetics.-
dc.languageeng-
dc.relation.ispartofHuman Immunology-
dc.subjectMICA-
dc.subjectDistribution-
dc.subjectHLA-
dc.subjectCantonese Han population-
dc.subjectSBT-
dc.titleDistribution of MICA haplotypes in a Chinese Han population-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.humimm.2011.08.021-
dc.identifier.pmid22100839-
dc.identifier.scopuseid_2-s2.0-84355161457-
dc.identifier.volume73-
dc.identifier.issue1-
dc.identifier.spage75-
dc.identifier.epage79-
dc.identifier.eissn1879-1166-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats