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Article: Prospective relationship between duration of untreated psychosis and 13-year clinical outcome: A first-episode psychosis study

TitleProspective relationship between duration of untreated psychosis and 13-year clinical outcome: A first-episode psychosis study
Authors
KeywordsLong-term outcome
Prospective study
Psychotic disorders
Remission
Duration of untreated psychosis
Risk factors
Issue Date2014
Citation
Schizophrenia Research, 2014, v. 153, n. 1-3, p. 1-8 How to Cite?
AbstractBackground: The adverse effects of a long duration of untreated psychosis (DUP) have been explored in numerous short-term studies. These studies support the development of early interventions that reduce treatment delay and promote recovery. However, the enduring impact of DUP is largely unknown, partly due to the paucity of prospective long-term studies. Although the DUP-outcome relationship is commonly assumed to be linear, the threshold effect has not been adequately examined. Objective: To explore the relationship between DUP and long-term symptomatic remission. Methods: This was a prospective study of a cohort of 153 first-episode psychosis patients in Hong Kong at the 13-year follow-up. The patients were categorized into short (≤. 30. days), medium (31-180. days) and long (>. 180. days) DUP groups. Results: The long-term outcome was ascertained in 73% of the patients. Nearly half of the patients (47%) fulfilled the criteria for symptomatic remission. The short DUP group experienced a significantly higher remission rate over the course of the illness. The odds of long-term symptomatic remission was significantly reduced in the medium DUP (by 89%) and long DUP (by 85%) groups compared with the short DUP group. Further analysis showed that DUP had a specific impact on negative symptom remission. Conclusion: The findings support the threshold theory that DUP longer than 30. days adversely impacts the long-term outcome. The present study is one of the few studies that confirmed the enduring impact of DUP on long-term outcomes based on well-defined criteria and adequate statistical adjustment. © 2014 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/207086
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, YMJ-
dc.contributor.authorChang, WC-
dc.contributor.authorHui, CLM-
dc.contributor.authorWong, Gloria Hoi Yan-
dc.contributor.authorChan, Sherry Kit Wa-
dc.contributor.authorLee, Edwin-
dc.contributor.authorYeung, Waisong-
dc.contributor.authorWong, Chikeung-
dc.contributor.authorTang, Wainang-
dc.contributor.authorChan, Wahfat-
dc.contributor.authorPang, Edwin Pui Fai-
dc.contributor.authorTso, Steve-
dc.contributor.authorNg, Roger-
dc.contributor.authorHung, Sefong-
dc.contributor.authorDunn, Eva Lai Wah-
dc.contributor.authorSham, Pak Chung-
dc.contributor.authorChen, Eric Yu Hai-
dc.date.accessioned2014-12-09T04:31:22Z-
dc.date.available2014-12-09T04:31:22Z-
dc.date.issued2014-
dc.identifier.citationSchizophrenia Research, 2014, v. 153, n. 1-3, p. 1-8-
dc.identifier.issn0920-9964-
dc.identifier.urihttp://hdl.handle.net/10722/207086-
dc.description.abstractBackground: The adverse effects of a long duration of untreated psychosis (DUP) have been explored in numerous short-term studies. These studies support the development of early interventions that reduce treatment delay and promote recovery. However, the enduring impact of DUP is largely unknown, partly due to the paucity of prospective long-term studies. Although the DUP-outcome relationship is commonly assumed to be linear, the threshold effect has not been adequately examined. Objective: To explore the relationship between DUP and long-term symptomatic remission. Methods: This was a prospective study of a cohort of 153 first-episode psychosis patients in Hong Kong at the 13-year follow-up. The patients were categorized into short (≤. 30. days), medium (31-180. days) and long (>. 180. days) DUP groups. Results: The long-term outcome was ascertained in 73% of the patients. Nearly half of the patients (47%) fulfilled the criteria for symptomatic remission. The short DUP group experienced a significantly higher remission rate over the course of the illness. The odds of long-term symptomatic remission was significantly reduced in the medium DUP (by 89%) and long DUP (by 85%) groups compared with the short DUP group. Further analysis showed that DUP had a specific impact on negative symptom remission. Conclusion: The findings support the threshold theory that DUP longer than 30. days adversely impacts the long-term outcome. The present study is one of the few studies that confirmed the enduring impact of DUP on long-term outcomes based on well-defined criteria and adequate statistical adjustment. © 2014 Elsevier B.V.-
dc.languageeng-
dc.relation.ispartofSchizophrenia Research-
dc.subjectLong-term outcome-
dc.subjectProspective study-
dc.subjectPsychotic disorders-
dc.subjectRemission-
dc.subjectDuration of untreated psychosis-
dc.subjectRisk factors-
dc.titleProspective relationship between duration of untreated psychosis and 13-year clinical outcome: A first-episode psychosis study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2014.01.022-
dc.identifier.pmid24529612-
dc.identifier.scopuseid_2-s2.0-84895835787-
dc.identifier.hkuros238226-
dc.identifier.hkuros229229-
dc.identifier.volume153-
dc.identifier.issue1-3-
dc.identifier.spage1-
dc.identifier.epage8-
dc.identifier.eissn1573-2509-
dc.identifier.isiWOS:000333052800001-

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