File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Histiocytic sarcoma of the brain

TitleHistiocytic sarcoma of the brain
Authors
KeywordsLympho-hematopoietic
Brain
Histiocytic sarcoma
Malignant tumour
Issue Date2012
Citation
Journal of Clinical Neuroscience, 2012, v. 19, n. 10, p. 1456-1458 How to Cite?
AbstractHistiocytic sarcoma is a rare malignant neoplasm of the lympho-hematopoietic system that usually occurs in the skin, lymph nodes and intestinal tract. We present a 36-year-old woman with a rare histiocytic sarcoma with isolated central nervous system (CNS) involvement of multifocal circumscribed lesions. Biopsy of the brain lesions showed diffuse proliferation of pleomorphic histiocytes that were immunopositive for CD45, CD68 and CD163. Various cytokeratins and markers of lymphoma, melanoma, germ cell tumours and primary CNS tumours were negative. Examination of bone marrow trephine and a whole-body positron emission tomography scan showed no evidence of involvement of any other organ systems, thus establishing the primary nature of the lesion. The neoplastic cells uniquely showed eosinophilic globules within the cytoplasm, which were positive for CD68. These globules were shown by electron microscopy to be collections of lysosomes. A thorough discussion of the differential diagnosis and literature review is included. © 2012 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/207064
ISSN
2015 Impact Factor: 1.387
2015 SCImago Journal Rankings: 0.609

 

DC FieldValueLanguage
dc.contributor.authorGill-Samra, Spinderjeet-
dc.contributor.authorNg, Thomas-
dc.contributor.authorDexter, Mark A J-
dc.contributor.authorWong, Mark-
dc.contributor.authorNahar, Najmun-
dc.contributor.authorAllsopp, Katherine-
dc.contributor.authorBoadle, Rose A.-
dc.contributor.authorVarikatt, Winny-
dc.date.accessioned2014-12-09T04:31:20Z-
dc.date.available2014-12-09T04:31:20Z-
dc.date.issued2012-
dc.identifier.citationJournal of Clinical Neuroscience, 2012, v. 19, n. 10, p. 1456-1458-
dc.identifier.issn0967-5868-
dc.identifier.urihttp://hdl.handle.net/10722/207064-
dc.description.abstractHistiocytic sarcoma is a rare malignant neoplasm of the lympho-hematopoietic system that usually occurs in the skin, lymph nodes and intestinal tract. We present a 36-year-old woman with a rare histiocytic sarcoma with isolated central nervous system (CNS) involvement of multifocal circumscribed lesions. Biopsy of the brain lesions showed diffuse proliferation of pleomorphic histiocytes that were immunopositive for CD45, CD68 and CD163. Various cytokeratins and markers of lymphoma, melanoma, germ cell tumours and primary CNS tumours were negative. Examination of bone marrow trephine and a whole-body positron emission tomography scan showed no evidence of involvement of any other organ systems, thus establishing the primary nature of the lesion. The neoplastic cells uniquely showed eosinophilic globules within the cytoplasm, which were positive for CD68. These globules were shown by electron microscopy to be collections of lysosomes. A thorough discussion of the differential diagnosis and literature review is included. © 2012 Elsevier Ltd. All rights reserved.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Neuroscience-
dc.subjectLympho-hematopoietic-
dc.subjectBrain-
dc.subjectHistiocytic sarcoma-
dc.subjectMalignant tumour-
dc.titleHistiocytic sarcoma of the brain-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jocn.2011.10.023-
dc.identifier.pmid22831650-
dc.identifier.scopuseid_2-s2.0-84866334463-
dc.identifier.volume19-
dc.identifier.issue10-
dc.identifier.spage1456-
dc.identifier.epage1458-
dc.identifier.eissn1532-2653-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats