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Article: Diagnostic pitfall in the diagnosis of mesenchymal chondrosarcoma arising in the central nervous system

TitleDiagnostic pitfall in the diagnosis of mesenchymal chondrosarcoma arising in the central nervous system
Authors
KeywordsDiagnosis
Mesenchymal chondrosarcoma
Small round cell tumor
Issue Date2012
Citation
Neuropathology, 2012, v. 32, n. 1, p. 82-90 How to Cite?
AbstractMesenchymal chondrosarcoma is a rare aggressive neoplasm typically affecting the bones of young adults. It may also arise in somatic soft tissue, the CNS and other organs. It has a characteristic biphasic histological pattern composed of highly undifferentiated small round cells and islands of well-differentiated hyaline cartilage. We report a case of mesenchymal chondrosarcoma arising from the right tentorium cerebelli in a 21-year-old woman with symptoms relating to mass effect. Histological examination demonstrated a purely small round cell appearance in a specimen obtained during partial resection at an outside institution, leading to an erroneous diagnosis of Ewing sarcoma/primitive neuroectodermal tumor (PNET). The diagnosis of mesenchymal chondrosarcoma was made only after tissue obtained during a definitive complete macroscopic removal involving the regional tentorium cerebelli, transverse and sigmoid dural venous sinuses which showed a prominent cartilaginous component. We discuss the features of mesenchymal chondrosarcoma arising in the CNS, the important differential diagnoses of small round-cell tumors within the CNS, and the differentiating features of mesenchymal chondrosarcoma from Ewing sarcoma/PNET, medulloblastoma, hemangiopericytoma, monophasic synovial sarcoma and atypical teratoid/rhabdoid tumour. © 2011 Japanese Society of Neuropathology.
Persistent Identifierhttp://hdl.handle.net/10722/207052
ISSN
2015 Impact Factor: 1.556
2015 SCImago Journal Rankings: 0.757

 

DC FieldValueLanguage
dc.contributor.authorLin, Lisa-
dc.contributor.authorVarikatt, Winny-
dc.contributor.authorDexter, Mark A J-
dc.contributor.authorNg, Thomas-
dc.date.accessioned2014-12-09T04:31:18Z-
dc.date.available2014-12-09T04:31:18Z-
dc.date.issued2012-
dc.identifier.citationNeuropathology, 2012, v. 32, n. 1, p. 82-90-
dc.identifier.issn0919-6544-
dc.identifier.urihttp://hdl.handle.net/10722/207052-
dc.description.abstractMesenchymal chondrosarcoma is a rare aggressive neoplasm typically affecting the bones of young adults. It may also arise in somatic soft tissue, the CNS and other organs. It has a characteristic biphasic histological pattern composed of highly undifferentiated small round cells and islands of well-differentiated hyaline cartilage. We report a case of mesenchymal chondrosarcoma arising from the right tentorium cerebelli in a 21-year-old woman with symptoms relating to mass effect. Histological examination demonstrated a purely small round cell appearance in a specimen obtained during partial resection at an outside institution, leading to an erroneous diagnosis of Ewing sarcoma/primitive neuroectodermal tumor (PNET). The diagnosis of mesenchymal chondrosarcoma was made only after tissue obtained during a definitive complete macroscopic removal involving the regional tentorium cerebelli, transverse and sigmoid dural venous sinuses which showed a prominent cartilaginous component. We discuss the features of mesenchymal chondrosarcoma arising in the CNS, the important differential diagnoses of small round-cell tumors within the CNS, and the differentiating features of mesenchymal chondrosarcoma from Ewing sarcoma/PNET, medulloblastoma, hemangiopericytoma, monophasic synovial sarcoma and atypical teratoid/rhabdoid tumour. © 2011 Japanese Society of Neuropathology.-
dc.languageeng-
dc.relation.ispartofNeuropathology-
dc.subjectDiagnosis-
dc.subjectMesenchymal chondrosarcoma-
dc.subjectSmall round cell tumor-
dc.titleDiagnostic pitfall in the diagnosis of mesenchymal chondrosarcoma arising in the central nervous system-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1789.2011.01224.x-
dc.identifier.pmid21615516-
dc.identifier.scopuseid_2-s2.0-84855933805-
dc.identifier.volume32-
dc.identifier.issue1-
dc.identifier.spage82-
dc.identifier.epage90-
dc.identifier.eissn1440-1789-

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