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Article: Usefulness of smears in intra-operative diagnosis of newly described entities of CNS: Review Article

TitleUsefulness of smears in intra-operative diagnosis of newly described entities of CNS: Review Article
Authors
KeywordsCytological features
Frozen sections
Intra-operative diagnosis
Brain smears
Newly described CNS tumours
Issue Date2009
Citation
Neuropathology, 2009, v. 29, n. 6, p. 641-648 How to Cite?
AbstractThe recent edition of World Health Organisation (WHO) Classification of Tumours of the Central Nervous System has incorporated a substantial number of important changes. It has recognised several new entities, many of which are rare. Intra-operative diagnosis of these tumours can be difficult with the freezing artefact that often cripples brain frozen sections. In many instances intra-operative smears are extremely useful adjuvants in neuropathological diagnosis. In this article, we describe intra-operative smear findings of three of the newly described tumours. Their characteristic cytologic features are illustrated along with differentiating features from the common mimics, together with a general approach to brain smears. The entities we discuss here are papillary glioneuronal tumour, papillary tumour of the pineal region and angiocentric glioma. All three tumours share at least focal pseudo-papillary/ vasculocentric architecture. Smears from papillary glioneuronal tumour demonstrated dual population of cells in a neuropil background, whereas papillary tumour of the pineal region and angiocentric glioma comprise a single population of cells. These two tumours can further be differentiated based on their cell morphology and background. © 2009 Japanese Society of Neuropathology.
Persistent Identifierhttp://hdl.handle.net/10722/207017
ISSN
2015 Impact Factor: 1.556
2015 SCImago Journal Rankings: 0.757

 

DC FieldValueLanguage
dc.contributor.authorVarikatt, Winny-
dc.contributor.authorDexter, Mark A J-
dc.contributor.authorMahajan, Hema-
dc.contributor.authorMurali, Rajmohan-
dc.contributor.authorNg, Thomas-
dc.date.accessioned2014-12-09T04:31:15Z-
dc.date.available2014-12-09T04:31:15Z-
dc.date.issued2009-
dc.identifier.citationNeuropathology, 2009, v. 29, n. 6, p. 641-648-
dc.identifier.issn0919-6544-
dc.identifier.urihttp://hdl.handle.net/10722/207017-
dc.description.abstractThe recent edition of World Health Organisation (WHO) Classification of Tumours of the Central Nervous System has incorporated a substantial number of important changes. It has recognised several new entities, many of which are rare. Intra-operative diagnosis of these tumours can be difficult with the freezing artefact that often cripples brain frozen sections. In many instances intra-operative smears are extremely useful adjuvants in neuropathological diagnosis. In this article, we describe intra-operative smear findings of three of the newly described tumours. Their characteristic cytologic features are illustrated along with differentiating features from the common mimics, together with a general approach to brain smears. The entities we discuss here are papillary glioneuronal tumour, papillary tumour of the pineal region and angiocentric glioma. All three tumours share at least focal pseudo-papillary/ vasculocentric architecture. Smears from papillary glioneuronal tumour demonstrated dual population of cells in a neuropil background, whereas papillary tumour of the pineal region and angiocentric glioma comprise a single population of cells. These two tumours can further be differentiated based on their cell morphology and background. © 2009 Japanese Society of Neuropathology.-
dc.languageeng-
dc.relation.ispartofNeuropathology-
dc.subjectCytological features-
dc.subjectFrozen sections-
dc.subjectIntra-operative diagnosis-
dc.subjectBrain smears-
dc.subjectNewly described CNS tumours-
dc.titleUsefulness of smears in intra-operative diagnosis of newly described entities of CNS: Review Article-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1789.2009.01038.x-
dc.identifier.pmid19563508-
dc.identifier.scopuseid_2-s2.0-70449674500-
dc.identifier.volume29-
dc.identifier.issue6-
dc.identifier.spage641-
dc.identifier.epage648-
dc.identifier.eissn1440-1789-

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