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Article: Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China

TitlePolymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China
Authors
KeywordsLung cancer
DNA repair
Single nucleotide polymorphism
Polycyclic aromatic hydrocarbon
Nucleotide excision repair
Issue Date2005
Citation
International Journal of Cancer, 2005, v. 116, n. 5, p. 768-773 How to Cite?
AbstractThe lung cancer mortality rate in Xuan Wei County is among the highest in China and has been attributed to exposure to indoor smoky coal emissions that contain very high levels of polycyclic aromatic hydrocarbons (PAHs). Nucleotide excision repair (NER) plays a key role in reversing DNA damage from exposure to environmental carcinogens, such as PAHs, that form bulky DNA adducts. We studied single nucleotide polymorphisms (SNPs) and their corresponding haplotypes in 6 genes (ERCC1, ERCC2/XPD, ERCC4/XPF, ERCC5/XPG, RAD23B and XPC) involved in NER in a population-based case-control study of lung cancer in Xuan Wei. A total of 122 incident primary lung cancer cases and 122 individually matched controls were enrolled. Three linked SNPs in ERCC2 were associated with lung cancer with similar ORs; e.g., persons with the Gln allele at codon 751 had a 60% reduction of lung cancer (OR = 0.40,95% CI 0.18-0.89). Moreover, one haplotype in ERCC2 was associated with a decreased risk of lung cancer (OR = 0.40, 95% CI 0.19-0.85) compared to the most common haplotype. In addition, subjects with one or 2 copies of the Val allele at codon 249 of RAD23B had a 2-fold increased risk of lung cancer (OR = 1.91, 95% CI 1.12-3.24). In summary, our results suggest that genetic variants in genes involved in the NER pathway may play a role in lung cancer susceptibility in Xuan Wei. However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and in other populations with substantial environmental exposure to PAHs. © 2005 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/207004
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657

 

DC FieldValueLanguage
dc.contributor.authorShen, Min-
dc.contributor.authorBerndt, Sonja I.-
dc.contributor.authorRothman, Nathaniel R.-
dc.contributor.authorDeMarini, David M.-
dc.contributor.authorMumford, Judy Lee-
dc.contributor.authorHe, Xingzhou-
dc.contributor.authorBonner, Matthew R.-
dc.contributor.authorTian, Linwei-
dc.contributor.authorYeager, Meredith-
dc.contributor.authorWelch, Robert A.-
dc.contributor.authorChanock, Stephen J.-
dc.contributor.authorZheng, Tongzhang-
dc.contributor.authorCaporaso, Neil E.-
dc.contributor.authorLan, Qing-
dc.date.accessioned2014-12-09T04:31:13Z-
dc.date.available2014-12-09T04:31:13Z-
dc.date.issued2005-
dc.identifier.citationInternational Journal of Cancer, 2005, v. 116, n. 5, p. 768-773-
dc.identifier.issn0020-7136-
dc.identifier.urihttp://hdl.handle.net/10722/207004-
dc.description.abstractThe lung cancer mortality rate in Xuan Wei County is among the highest in China and has been attributed to exposure to indoor smoky coal emissions that contain very high levels of polycyclic aromatic hydrocarbons (PAHs). Nucleotide excision repair (NER) plays a key role in reversing DNA damage from exposure to environmental carcinogens, such as PAHs, that form bulky DNA adducts. We studied single nucleotide polymorphisms (SNPs) and their corresponding haplotypes in 6 genes (ERCC1, ERCC2/XPD, ERCC4/XPF, ERCC5/XPG, RAD23B and XPC) involved in NER in a population-based case-control study of lung cancer in Xuan Wei. A total of 122 incident primary lung cancer cases and 122 individually matched controls were enrolled. Three linked SNPs in ERCC2 were associated with lung cancer with similar ORs; e.g., persons with the Gln allele at codon 751 had a 60% reduction of lung cancer (OR = 0.40,95% CI 0.18-0.89). Moreover, one haplotype in ERCC2 was associated with a decreased risk of lung cancer (OR = 0.40, 95% CI 0.19-0.85) compared to the most common haplotype. In addition, subjects with one or 2 copies of the Val allele at codon 249 of RAD23B had a 2-fold increased risk of lung cancer (OR = 1.91, 95% CI 1.12-3.24). In summary, our results suggest that genetic variants in genes involved in the NER pathway may play a role in lung cancer susceptibility in Xuan Wei. However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and in other populations with substantial environmental exposure to PAHs. © 2005 Wiley-Liss, Inc.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Cancer-
dc.subjectLung cancer-
dc.subjectDNA repair-
dc.subjectSingle nucleotide polymorphism-
dc.subjectPolycyclic aromatic hydrocarbon-
dc.subjectNucleotide excision repair-
dc.titlePolymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ijc.21117-
dc.identifier.pmid15849729-
dc.identifier.scopuseid_2-s2.0-23244437172-
dc.identifier.volume116-
dc.identifier.issue5-
dc.identifier.spage768-
dc.identifier.epage773-

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