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Article: Oophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

TitleOophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
Authors
Issue Date2012
Citation
Cancer Epidemiology, Biomarkers & Prevention , 2012, v. 21 n. 7, p. 1089-96 How to Cite?
AbstractBackground: To evaluate the effect of the cumulative number of ovulatory cycles and its contributing components on the risk of breast cancer among BRCA mutation carriers. Methods: We conducted a matched case–control study on 2,854 pairs of women with a BRCA1 or BRCA2 mutation. Conditional logistic regression was used to estimate the association between the number of ovulatory cycles and various exposures and the risk of breast cancer. Information from a subset of these women enrolled in a prospective cohort study was used to calculate age-specific breast cancer rates. Results: The annual risk of breast cancer decreased with the number of ovulatory cycles experienced (ρ = −0.69; P = 0.03). Age at menarche and duration of breastfeeding were inversely related with risk of breast cancer among BRCA1 (Ptrend < 0.0001) but not among BRCA2 (Ptrend ≥ 0.28) mutation carriers. The reduction in breast cancer risk associated with surgical menopause [OR, 0.52; 95% confidence interval (CI), 0.40–0.66; Ptrend < 0.0001] was greater than that associated with natural menopause (OR, 0.81; 95% CI, 0.62–1.07; Ptrend = 0.14). There was a highly significant reduction in breast cancer risk among women who had an oophorectomy after natural menopause (OR, 0.13; 95% CI, 0.02–0.54; P = 0.006). Conclusions: These data challenge the hypothesis that breast cancer risk can be predicted by the lifetime number of ovulatory cycles in women with a BRCA mutation. Both pre- and postmenopausal oophorectomy protect against breast cancer. Impact: Understanding the basis for the protective effect of oophorectomy has important implications for chemoprevention. Cancer Epidemiol Biomarkers Prev; 21(7); 1089–96. ©2012 AACR.
Persistent Identifierhttp://hdl.handle.net/10722/206835

 

DC FieldValueLanguage
dc.contributor.authorKotsopoulos, Jen_US
dc.contributor.authorLubinski, Jen_US
dc.contributor.authorLynch, HTen_US
dc.contributor.authorKim-Sing, Cen_US
dc.contributor.authorNeuhausen, Sen_US
dc.contributor.authorDemsky, Ren_US
dc.contributor.authorFoulkes, WDen_US
dc.contributor.authorGhadirian, Pen_US
dc.contributor.authorTung, Nen_US
dc.contributor.authorAinsworth, Pen_US
dc.contributor.authorSenter, Len_US
dc.contributor.authorKarlan, Ben_US
dc.contributor.authorEisen, Aen_US
dc.contributor.authorEng, Cen_US
dc.contributor.authorWeitzel, Jen_US
dc.contributor.authorGilchrist, DMen_US
dc.contributor.authorBlum, JLen_US
dc.contributor.authorKwong, Aen_US
dc.date.accessioned2014-12-02T10:06:26Z-
dc.date.available2014-12-02T10:06:26Z-
dc.date.issued2012en_US
dc.identifier.citationCancer Epidemiology, Biomarkers & Prevention , 2012, v. 21 n. 7, p. 1089-96en_US
dc.identifier.urihttp://hdl.handle.net/10722/206835-
dc.description.abstractBackground: To evaluate the effect of the cumulative number of ovulatory cycles and its contributing components on the risk of breast cancer among BRCA mutation carriers. Methods: We conducted a matched case–control study on 2,854 pairs of women with a BRCA1 or BRCA2 mutation. Conditional logistic regression was used to estimate the association between the number of ovulatory cycles and various exposures and the risk of breast cancer. Information from a subset of these women enrolled in a prospective cohort study was used to calculate age-specific breast cancer rates. Results: The annual risk of breast cancer decreased with the number of ovulatory cycles experienced (ρ = −0.69; P = 0.03). Age at menarche and duration of breastfeeding were inversely related with risk of breast cancer among BRCA1 (Ptrend < 0.0001) but not among BRCA2 (Ptrend ≥ 0.28) mutation carriers. The reduction in breast cancer risk associated with surgical menopause [OR, 0.52; 95% confidence interval (CI), 0.40–0.66; Ptrend < 0.0001] was greater than that associated with natural menopause (OR, 0.81; 95% CI, 0.62–1.07; Ptrend = 0.14). There was a highly significant reduction in breast cancer risk among women who had an oophorectomy after natural menopause (OR, 0.13; 95% CI, 0.02–0.54; P = 0.006). Conclusions: These data challenge the hypothesis that breast cancer risk can be predicted by the lifetime number of ovulatory cycles in women with a BRCA mutation. Both pre- and postmenopausal oophorectomy protect against breast cancer. Impact: Understanding the basis for the protective effect of oophorectomy has important implications for chemoprevention. Cancer Epidemiol Biomarkers Prev; 21(7); 1089–96. ©2012 AACR.en_US
dc.languageengen_US
dc.relation.ispartofCancer Epidemiology, Biomarkers & Preventionen_US
dc.titleOophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriersen_US
dc.typeArticleen_US
dc.identifier.emailKwong, A: avakwong@hkucc.hku.hken_US
dc.identifier.authorityKwong, A=rp01734en_US
dc.identifier.doi10.1158/1055-9965.EPI-12-0201en_US
dc.identifier.hkuros241586en_US
dc.identifier.volume21en_US
dc.identifier.issue7en_US
dc.identifier.spage1089en_US
dc.identifier.epage96en_US

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