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  Patent History
  • Application
    US 11/192194 2005-07-28
  • Publication
    US 20060037085 2006-02-16
  Patent Family
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published patent: Animal model for fetal alcohol syndrome and methods of treatment

TitleAnimal model for fetal alcohol syndrome and methods of treatment
Priority Date2005-07-28 US 11/192194
2004-08-13 US 10/601443P
Inventors
Issue Date2006
Citation
US Published patent application US 20060037085. Washington, DC: US Patent and Trademark Office (USPTO), 2006 How to Cite?
AbstractA Xenopus laevis (the African clawed frog) embryo model is provided to study the effects of alcohol on fetal development. Exposure of Xenopus embryos in specific developmental stages to alcohol results in tadpoles with microencephaly and growth retardation, in a dose- and time-dependent manner, similar to those observed in human fetal alcohol syndrome (FAS). The invention further provides methods for screening an agent to determine its usefulness for preventing or treating FAS. Moreover, the invention provides methods for preventing or treating FAS in an animal by administering an agent, such an agent includes vitamin C and a catalase, which causes or enhances an expression of Pax6 that is a neural and eye marker. In addition, the invention provides methods for preventing or treating FAS by administering an agent, such as vitamin C, which causes suppression of NF-kappaB activation.
Persistent Identifierhttp://hdl.handle.net/10722/206716

 

DC FieldValueLanguage
dc.date.accessioned2014-11-28T03:41:32Z-
dc.date.available2014-11-28T03:41:32Z-
dc.date.issued2006en_US
dc.identifier.citationUS Published patent application US 20060037085. Washington, DC: US Patent and Trademark Office (USPTO), 2006en_US
dc.identifier.urihttp://hdl.handle.net/10722/206716-
dc.description.abstractA Xenopus laevis (the African clawed frog) embryo model is provided to study the effects of alcohol on fetal development. Exposure of Xenopus embryos in specific developmental stages to alcohol results in tadpoles with microencephaly and growth retardation, in a dose- and time-dependent manner, similar to those observed in human fetal alcohol syndrome (FAS). The invention further provides methods for screening an agent to determine its usefulness for preventing or treating FAS. Moreover, the invention provides methods for preventing or treating FAS in an animal by administering an agent, such an agent includes vitamin C and a catalase, which causes or enhances an expression of Pax6 that is a neural and eye marker. In addition, the invention provides methods for preventing or treating FAS by administering an agent, such as vitamin C, which causes suppression of NF-kappaB activation.en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License for public patent documentsen_US
dc.titleAnimal model for fetal alcohol syndrome and methods of treatmenten_US
dc.typePatenten_US
dc.identifier.authorityLIN, MARIE C=rp00746en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.hkuros92080en_US
dc.contributor.inventorPENG, YINGen_US
dc.contributor.inventorLIN, MARIE Cen_US
dc.contributor.inventorKUNG, HSIANG-FUen_US
dc.contributor.inventorYANG, PAI-HAOen_US
patents.identifier.applicationUS 11/192194en_US
patents.description.countryUnited States of Americaen_US
patents.date.publication2006-02-16en_US
patents.date.application2005-07-28en_US
patents.date.priority2005-07-28 US 11/192194en_US
patents.date.priority2004-08-13 US 10/601443Pen_US
patents.description.ccusen_US
patents.identifier.publicationUS 20060037085en_US
patents.relation.familyCN 1799631 (A) 2006-07-12en_US
patents.description.kindA1en_US
patents.typePatent_publisheden_US

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