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  Patent History
  • Application
    US 12/4078010 2013-11-12
  • Publication
    US 20140135271 2014-05-15
  Patent Family
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Patent: Lamin A, An Activator of Longevity/Anti-Aging SIRT1 Protein

TitleLamin A, An Activator of Longevity/Anti-Aging SIRT1 Protein
Priority Date2013-11-12 US 12/4078010
2012-11-12 US 12/1725252P
Inventors
Issue Date2014
Citation
US Published patent application US 20140135271. Washington, DC: US Patent and Trademark Office (USPTO), 2014 How to Cite?
AbstractIn one embodiment, the present invention provides methods of modulating the deacetylase activity of SIRT1 in one or more cell by modifying the binding affinity of lamin A to SIRT1 via one or more interaction modifying compound. In another embodiment, the present invention provides methods of screening SIRT1-activating/inhibiting compounds based on the interaction between lamin A and SIRT1 proteins and SIRT1-activating property of lamin A. In another embodiment, the present invention provides uses of SIRT1-activating compounds to treat patient(s) suffering from metabolic and/or aging-related degenerative diseases, and uses of SIRT1-inhibiting compounds to treat human malignancies.
Persistent Identifierhttp://hdl.handle.net/10722/206620

 

DC FieldValueLanguage
dc.date.accessioned2014-11-21T08:05:33Z-
dc.date.available2014-11-21T08:05:33Z-
dc.date.issued2014en_US
dc.identifier.citationUS Published patent application US 20140135271. Washington, DC: US Patent and Trademark Office (USPTO), 2014en_US
dc.identifier.urihttp://hdl.handle.net/10722/206620-
dc.description.abstractIn one embodiment, the present invention provides methods of modulating the deacetylase activity of SIRT1 in one or more cell by modifying the binding affinity of lamin A to SIRT1 via one or more interaction modifying compound. In another embodiment, the present invention provides methods of screening SIRT1-activating/inhibiting compounds based on the interaction between lamin A and SIRT1 proteins and SIRT1-activating property of lamin A. In another embodiment, the present invention provides uses of SIRT1-activating compounds to treat patient(s) suffering from metabolic and/or aging-related degenerative diseases, and uses of SIRT1-inhibiting compounds to treat human malignancies.en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License for public patent documentsen_US
dc.titleLamin A, An Activator of Longevity/Anti-Aging SIRT1 Proteinen_US
dc.typePatenten_US
dc.identifier.authorityZHOU, ZHONGJUN=rp00503en_US
dc.identifier.authorityLIU, BAOHUA=rp01485en_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorZHOU, ZHONGJUNen_US
dc.contributor.inventorLIU, BAOHUAen_US
patents.identifier.applicationUS 12/4078010en_US
patents.description.assigneeUNIV HONG KONG [CN]en_US
patents.description.countryUnited States of Americaen_US
patents.date.publication2014-05-15en_US
patents.identifier.hkutechidBioch-2012-00445-1en_US
patents.date.application2013-11-12en_US
patents.date.priority2013-11-12 US 12/4078010en_US
patents.date.priority2012-11-12 US 12/1725252Pen_US
patents.description.ccusen_US
patents.identifier.publicationUS 20140135271en_US
patents.relation.familyWO 2014071892 (A1) 2014-05-15en_US
patents.description.kindA1en_US

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