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postgraduate thesis: Effects of postnatal interference of vestibular GABA transmission on navigation behavior in adult rats

TitleEffects of postnatal interference of vestibular GABA transmission on navigation behavior in adult rats
Authors
Issue Date2014
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
Citation
Au, Z. W. [歐哲彣]. (2014). Effects of postnatal interference of vestibular GABA transmission on navigation behavior in adult rats. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5319513
AbstractAlthough spatial navigation is predominantly guided by allothetic visual cues, idiothetic cues can obtain control when familiar visual cues are not available. In path integration, the current position and orientation are estimated and continuously updated using idiothetic cues, which are contributed by the vestibular system. Previous studies have revealed that vestibular lesioned rats were significantly impaired in path integration. Rats assessed in the current study received neonatal treatment with either VU0240551 (KCC2 blocker) or muscimol (GABAA receptors agonist) in the vestibular nuclei. Path integration ability appears to be intact in rats receiving either treatment. However, VU0240551-treated rats displayed impairments in their ability to resolve conflicting allothetic and idiothetic cues. Therefore, it is proposed that the ability to properly resolve a cue-conflict requires the normal polarity of GABA and/or glycine action in the vestibular nuclei during the neonatal period.
DegreeMaster of Medical Sciences
SubjectSpatial behavior in animals
Dept/ProgramPhysiology
Persistent Identifierhttp://hdl.handle.net/10722/206562

 

DC FieldValueLanguage
dc.contributor.authorAu, Zher Wen-
dc.contributor.author歐哲彣-
dc.date.accessioned2014-11-19T23:15:29Z-
dc.date.available2014-11-19T23:15:29Z-
dc.date.issued2014-
dc.identifier.citationAu, Z. W. [歐哲彣]. (2014). Effects of postnatal interference of vestibular GABA transmission on navigation behavior in adult rats. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5319513-
dc.identifier.urihttp://hdl.handle.net/10722/206562-
dc.description.abstractAlthough spatial navigation is predominantly guided by allothetic visual cues, idiothetic cues can obtain control when familiar visual cues are not available. In path integration, the current position and orientation are estimated and continuously updated using idiothetic cues, which are contributed by the vestibular system. Previous studies have revealed that vestibular lesioned rats were significantly impaired in path integration. Rats assessed in the current study received neonatal treatment with either VU0240551 (KCC2 blocker) or muscimol (GABAA receptors agonist) in the vestibular nuclei. Path integration ability appears to be intact in rats receiving either treatment. However, VU0240551-treated rats displayed impairments in their ability to resolve conflicting allothetic and idiothetic cues. Therefore, it is proposed that the ability to properly resolve a cue-conflict requires the normal polarity of GABA and/or glycine action in the vestibular nuclei during the neonatal period.-
dc.languageeng-
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)-
dc.relation.ispartofHKU Theses Online (HKUTO)-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.-
dc.subject.lcshSpatial behavior in animals-
dc.titleEffects of postnatal interference of vestibular GABA transmission on navigation behavior in adult rats-
dc.typePG_Thesis-
dc.identifier.hkulb5319513-
dc.description.thesisnameMaster of Medical Sciences-
dc.description.thesislevelMaster-
dc.description.thesisdisciplinePhysiology-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5353/th_b5319513-

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