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Conference Paper: The role of c-Myc in regulating HIV-1 Tat protein induced cytokine expression and consequent effects on opportunistic infection

TitleThe role of c-Myc in regulating HIV-1 Tat protein induced cytokine expression and consequent effects on opportunistic infection
Authors
Issue Date2013
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
Citation
The Annual Meeting of the American Association of Immunologists (AAI) on Immunology (Immunology 2013), Honolulu, Hawaii, 3-7 May 2013. In Journal of Immunology, 2013, v. 190 n. Meeting Abstract Supplement, p. abstract no. 130.17 How to Cite?
AbstractThe human immunodeficiency virus (HIV-1) trans-activator (Tat) protein is an important viral protein that is known to contribute to the acquired immunodeficiency syndrome (AIDS) pathogenesis via cytokine dysregulation. In this study, we recognized that c-Myc regulated primary blood derived macrophage (PBMac) immune response induced by HIV-1 Tat. Treatment of PBMac with HIV-1 Tat was able to upregulate c-Myc expression in a time dependent manner. We subsequently delineated that HIV-1 Tat regulated c-Myc expression and function through the activation of dsRNA-activated protein kinase (PKR), ERK1/2 and p38 mitogen-activated protein kinase (MAPK). By knocking down the expression of c-Myc with gene specific small-interfering RNA (siRNA), we demonstrated that c-Myc may be critical for the expression of the pro-inflammatory cytokines TNF-α and IL-6. To further investigate the role of c-Myc in AIDS pathogenesis and its effects in the fight against the opportunistic microbes, Mycobacteria avium intracellulare, was used as a pathogen model. Our recent results demonstrated that HIV-1 Tat induced c-Myc to dysregulate cytokine expression, which affects the M. avium intracellular survival in PBMac. In summary, c-Myc may play a significant role in the pathogenesis of AIDS by regulating the cytokine expression by HIV-1 Tat and possibly further enhancing the infection of opportunistic pathogens in AIDS patients.
Persistent Identifierhttp://hdl.handle.net/10722/206055
ISSN
2015 Impact Factor: 4.985
2015 SCImago Journal Rankings: 3.549

 

DC FieldValueLanguage
dc.contributor.authorPong, CHen_US
dc.contributor.authorLi, CBen_US
dc.contributor.authorYim, HCHen_US
dc.contributor.authorLau, ASYen_US
dc.date.accessioned2014-10-20T11:47:25Z-
dc.date.available2014-10-20T11:47:25Z-
dc.date.issued2013en_US
dc.identifier.citationThe Annual Meeting of the American Association of Immunologists (AAI) on Immunology (Immunology 2013), Honolulu, Hawaii, 3-7 May 2013. In Journal of Immunology, 2013, v. 190 n. Meeting Abstract Supplement, p. abstract no. 130.17en_US
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10722/206055-
dc.description.abstractThe human immunodeficiency virus (HIV-1) trans-activator (Tat) protein is an important viral protein that is known to contribute to the acquired immunodeficiency syndrome (AIDS) pathogenesis via cytokine dysregulation. In this study, we recognized that c-Myc regulated primary blood derived macrophage (PBMac) immune response induced by HIV-1 Tat. Treatment of PBMac with HIV-1 Tat was able to upregulate c-Myc expression in a time dependent manner. We subsequently delineated that HIV-1 Tat regulated c-Myc expression and function through the activation of dsRNA-activated protein kinase (PKR), ERK1/2 and p38 mitogen-activated protein kinase (MAPK). By knocking down the expression of c-Myc with gene specific small-interfering RNA (siRNA), we demonstrated that c-Myc may be critical for the expression of the pro-inflammatory cytokines TNF-α and IL-6. To further investigate the role of c-Myc in AIDS pathogenesis and its effects in the fight against the opportunistic microbes, Mycobacteria avium intracellulare, was used as a pathogen model. Our recent results demonstrated that HIV-1 Tat induced c-Myc to dysregulate cytokine expression, which affects the M. avium intracellular survival in PBMac. In summary, c-Myc may play a significant role in the pathogenesis of AIDS by regulating the cytokine expression by HIV-1 Tat and possibly further enhancing the infection of opportunistic pathogens in AIDS patients.-
dc.languageengen_US
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org-
dc.relation.ispartofJournal of Immunologyen_US
dc.rightsThis is an author-produced version of a manuscript accepted for publication in The Journal of Immunology (The JI). The American Association of Immunologists, Inc. (The AAI), publisher of The JI, holds the copyright to this manuscript. This manuscript has not yet been copyedited or subjected to editorial proofreading by The JI; hence, it may differ from the final version published in The JI (online and in print). The AAI (The JI) is not liable for errors or omissions in this author-produced version of the manuscript or in any version derived from it by the National Institutes of Health or any other third party. The final, citable version of record can be found at www.jimmunol.org-
dc.titleThe role of c-Myc in regulating HIV-1 Tat protein induced cytokine expression and consequent effects on opportunistic infectionen_US
dc.typeConference_Paperen_US
dc.identifier.emailPong, CH: jchpong@hku.hken_US
dc.identifier.emailLi, CB: jamesli@graduate.hku.hken_US
dc.identifier.emailYim, HCH: chhyim@graduate.hku.hken_US
dc.identifier.emailLau, ASY: asylau@hku.hken_US
dc.identifier.authorityLi, CB=rp00496en_US
dc.identifier.authorityLau, ASY=rp00474en_US
dc.identifier.hkuros241335en_US
dc.identifier.volume190-
dc.identifier.issueMeeting Abstract Supplement-
dc.publisher.placeUnited States-

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