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Article: Effect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin-starch conjugates in rats

TitleEffect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin-starch conjugates in rats
Authors
KeywordsCerebral hypoxia
Lactate
Hemoglobin based oxygen carrier
Hemodilution
Issue Date2009
Citation
Intensive Care Medicine, 2009, v. 35, n. 11, p. 1925-1933 How to Cite?
AbstractPurpose: To determine the oxygen affinity for optimal tissue oxygen delivery with a hemoglobin-hydroxyethyl starch conjugate (HRC 101). Methods: Anesthetized rats were hemodiluted (180 ml kg -1) with low (P 50 ∼ 70 mmHg) or high affinity (P 50 ∼ 14 mmHg) HRC 101 at hemoglobin (Hb) concentrations near 100 or 70 g l -1 (n = 6-8). Hippocampal tissue oxygen tension (P BrO 2), blood flow, arterial blood gases, Hb, hematocrit (Hct) and lactate were measured. Data (mean ± SD) were analyzed by two-way ANOVA. Results: Hemodilution reduced the hematocrit to 1 ± 1% in all groups. PB rO 2 was best maintained after hemodilution with low affinity HRC 101 at Hb 100 and 70 g l -1(25.2 ± 7.6 and 16.6 ± 8.3 torr, respectively). P BrO 2 decreased (9.5 ± 9.3 torr, P < 0.05) and serum lactate levels increased (5.0 ±1.7 mmol l -1, P < 0.05) following hemodilution with the high affinity HRC 101 (Hb 100 g l -1). Conclusions: HRC 101 with a lower oxygen affinity favored tissue perfusion and maintained P BrO 2 after near complete blood volume exchange in rats. © Springer-Verlag 2009.
Persistent Identifierhttp://hdl.handle.net/10722/205731
ISSN
2015 Impact Factor: 10.125
2015 SCImago Journal Rankings: 3.765
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHaré, Gregory M T-
dc.contributor.authorLiu, Elaine-
dc.contributor.authorBaker, Andrew J.-
dc.contributor.authorMazer, Cynthia David-
dc.date.accessioned2014-10-06T08:02:16Z-
dc.date.available2014-10-06T08:02:16Z-
dc.date.issued2009-
dc.identifier.citationIntensive Care Medicine, 2009, v. 35, n. 11, p. 1925-1933-
dc.identifier.issn0342-4642-
dc.identifier.urihttp://hdl.handle.net/10722/205731-
dc.description.abstractPurpose: To determine the oxygen affinity for optimal tissue oxygen delivery with a hemoglobin-hydroxyethyl starch conjugate (HRC 101). Methods: Anesthetized rats were hemodiluted (180 ml kg -1) with low (P 50 ∼ 70 mmHg) or high affinity (P 50 ∼ 14 mmHg) HRC 101 at hemoglobin (Hb) concentrations near 100 or 70 g l -1 (n = 6-8). Hippocampal tissue oxygen tension (P BrO 2), blood flow, arterial blood gases, Hb, hematocrit (Hct) and lactate were measured. Data (mean ± SD) were analyzed by two-way ANOVA. Results: Hemodilution reduced the hematocrit to 1 ± 1% in all groups. PB rO 2 was best maintained after hemodilution with low affinity HRC 101 at Hb 100 and 70 g l -1(25.2 ± 7.6 and 16.6 ± 8.3 torr, respectively). P BrO 2 decreased (9.5 ± 9.3 torr, P < 0.05) and serum lactate levels increased (5.0 ±1.7 mmol l -1, P < 0.05) following hemodilution with the high affinity HRC 101 (Hb 100 g l -1). Conclusions: HRC 101 with a lower oxygen affinity favored tissue perfusion and maintained P BrO 2 after near complete blood volume exchange in rats. © Springer-Verlag 2009.-
dc.languageeng-
dc.relation.ispartofIntensive Care Medicine-
dc.subjectCerebral hypoxia-
dc.subjectLactate-
dc.subjectHemoglobin based oxygen carrier-
dc.subjectHemodilution-
dc.titleEffect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin-starch conjugates in rats-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00134-009-1532-2-
dc.identifier.pmid19590850-
dc.identifier.scopuseid_2-s2.0-73949122750-
dc.identifier.volume35-
dc.identifier.issue11-
dc.identifier.spage1925-
dc.identifier.epage1933-
dc.identifier.eissn1432-1238-
dc.identifier.isiWOS:000271026300015-

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