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Article: β2 adrenergic antagonist inhibits cerebral cortical oxygen delivery after severe haemodilution in rats

Titleβ2 adrenergic antagonist inhibits cerebral cortical oxygen delivery after severe haemodilution in rats
Authors
KeywordsHaemodilution
Cerebral tissue oxygen tension
Cerebral hypoxia
Cerebral blood flow
β2 adrenergic blockade
Issue Date2006
Citation
British Journal of Anaesthesia, 2006, v. 97, n. 5, p. 617-623 How to Cite?
AbstractBackground. Haemodilution has been associated with neurological morbidity in surgical patients. This study tests the hypothesis that inhibition of cerebral vasodilatation by systemic β2 adrenergic blockade would impair cerebral oxygen delivery leading to tissue hypoxia in severely haemodiluted rats. Methods. Under general an aesthesia, cerebral tissue probes were placed to measure temperature, regional cerebral blood flow (rCBF) and tissue oxygen tension (PBrO2) in the parietal cerebral cortex or hippocampus. Baseline measurements were established before and after systemic administration of either a β2 antagonist (10 mg kg-1 i.v., ICI 118, 551) or saline vehicle. Acute haemodilution was then performed by simultaneously exchanging 50% of the estimated blood volume (30 ml kg-1) with pentastarch. Arterial blood gases (ABGs), haemoglobin concentration (co-oximetry), mean arterial blood pressure (MAP) and heart rate (HR) were also measured. Data were analysed using a two-way anova and post hoc Tukey's test [mean (sd)]. Results. Haemodilution reduced the haemoglobin concentration comparably in all groups [71 (9) g litre-1]. There were no differences in ABGs, co-oximetry, HR and MAP measurements between control and β2 blocked rats, either before or 60 min after drug or vehicle administration. In rats treated with the β2 antagonist there was a significant reduction in parietal cerebral cortical temperature, regional blood flow and tissue oxygen tension, relative to control rats, 60 min after haemodilution (P<0.05 for each). These differences were not observed when probes were placed in the hippocampus. Conclusion. Systemic β2 adrenergic blockade inhibited the compensatory increase in parietal cerebral cortical oxygen delivery after haemodilution thereby reducing cerebral cortical tissue oxygen tension. © 2006 Oxford University Press.
Persistent Identifierhttp://hdl.handle.net/10722/205700
ISSN
2015 Impact Factor: 5.616
2015 SCImago Journal Rankings: 2.314
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHaré, Gregory M T-
dc.contributor.authorWorrall, J. M A-
dc.contributor.authorBaker, Andrew J.-
dc.contributor.authorLiu, Elaine-
dc.contributor.authorSikich, Nancy-
dc.contributor.authorMazer, Cynthia David-
dc.date.accessioned2014-10-06T08:02:13Z-
dc.date.available2014-10-06T08:02:13Z-
dc.date.issued2006-
dc.identifier.citationBritish Journal of Anaesthesia, 2006, v. 97, n. 5, p. 617-623-
dc.identifier.issn0007-0912-
dc.identifier.urihttp://hdl.handle.net/10722/205700-
dc.description.abstractBackground. Haemodilution has been associated with neurological morbidity in surgical patients. This study tests the hypothesis that inhibition of cerebral vasodilatation by systemic β2 adrenergic blockade would impair cerebral oxygen delivery leading to tissue hypoxia in severely haemodiluted rats. Methods. Under general an aesthesia, cerebral tissue probes were placed to measure temperature, regional cerebral blood flow (rCBF) and tissue oxygen tension (PBrO2) in the parietal cerebral cortex or hippocampus. Baseline measurements were established before and after systemic administration of either a β2 antagonist (10 mg kg-1 i.v., ICI 118, 551) or saline vehicle. Acute haemodilution was then performed by simultaneously exchanging 50% of the estimated blood volume (30 ml kg-1) with pentastarch. Arterial blood gases (ABGs), haemoglobin concentration (co-oximetry), mean arterial blood pressure (MAP) and heart rate (HR) were also measured. Data were analysed using a two-way anova and post hoc Tukey's test [mean (sd)]. Results. Haemodilution reduced the haemoglobin concentration comparably in all groups [71 (9) g litre-1]. There were no differences in ABGs, co-oximetry, HR and MAP measurements between control and β2 blocked rats, either before or 60 min after drug or vehicle administration. In rats treated with the β2 antagonist there was a significant reduction in parietal cerebral cortical temperature, regional blood flow and tissue oxygen tension, relative to control rats, 60 min after haemodilution (P<0.05 for each). These differences were not observed when probes were placed in the hippocampus. Conclusion. Systemic β2 adrenergic blockade inhibited the compensatory increase in parietal cerebral cortical oxygen delivery after haemodilution thereby reducing cerebral cortical tissue oxygen tension. © 2006 Oxford University Press.-
dc.languageeng-
dc.relation.ispartofBritish Journal of Anaesthesia-
dc.subjectHaemodilution-
dc.subjectCerebral tissue oxygen tension-
dc.subjectCerebral hypoxia-
dc.subjectCerebral blood flow-
dc.subjectβ2 adrenergic blockade-
dc.titleβ2 adrenergic antagonist inhibits cerebral cortical oxygen delivery after severe haemodilution in rats-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/bja/ael238-
dc.identifier.pmid16956895-
dc.identifier.scopuseid_2-s2.0-33750139990-
dc.identifier.volume97-
dc.identifier.issue5-
dc.identifier.spage617-
dc.identifier.epage623-
dc.identifier.eissn1471-6771-
dc.identifier.isiWOS:000241277500005-

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