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Article: Endobronchial ultrasound: new insight for the diagnosis of sarcoidosis

TitleEndobronchial ultrasound: new insight for the diagnosis of sarcoidosis
Authors
Issue Date2007
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
The European Respiratory Journal, 2007, v. 29 n. 6, p. 1182-1186 How to Cite?
AbstractA diagnosis of sarcoidosis should be substantiated by pathological means in order to thoroughly exclude other diseases. The role of real-time endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of sarcoidosis has not been reported. The purpose of the present study is to evaluate the diagnostic yield of EBUS-TBNA in demonstrating the pathological features of sarcoidosis. In total, 65 patients with suspected sarcoidosis, with enlarged hilar or mediastinal lymph nodes on computed tomography, were included in the study. Patients with a suspected or known malignancy or previously established diagnosis of sarcoidosis were excluded. Convex probe endobronchial ultrasonography integrated with a separate working channel was used for EBUS-TBNA. Surgical methods were performed in those in whom no granulomas were detected by EBUS-TBNA. Patients were followed up clinically. EBUS-TBNA was performed on a total of 77 lymph node stations in 65 patients. A final diagnosis of sarcoidosis was made for 61 (93.8%) of the patients. The remaining four patients were diagnosed as having Wegener's granulomatosis (n=1) or indefinite (n=3). In patients with a final diagnosis of sarcoidosis, EBUS-TBNA demonstrated noncaseating epithelioid cell granulomas in 56 (91.8%) of the patients. No complications were reported. Endobronchial ultrasound-guided transbronchial needle aspiration proved to be a safe procedure with a high yield for the diagnoses of sarcoidosis.
Persistent Identifierhttp://hdl.handle.net/10722/205680
ISSN
2015 Impact Factor: 8.332
2015 SCImago Journal Rankings: 3.204
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, M-
dc.contributor.authorYasufuku, K-
dc.contributor.authorNakajima, T-
dc.contributor.authorHerth, FJF-
dc.contributor.authorSekine, Y-
dc.contributor.authorShibuya, K-
dc.contributor.authorIizasa, T-
dc.contributor.authorHiroshima, K-
dc.contributor.authorLam, WK-
dc.contributor.authorFujisawa, T-
dc.date.accessioned2014-09-30T08:45:40Z-
dc.date.available2014-09-30T08:45:40Z-
dc.date.issued2007-
dc.identifier.citationThe European Respiratory Journal, 2007, v. 29 n. 6, p. 1182-1186-
dc.identifier.issn0903-1936-
dc.identifier.urihttp://hdl.handle.net/10722/205680-
dc.description.abstractA diagnosis of sarcoidosis should be substantiated by pathological means in order to thoroughly exclude other diseases. The role of real-time endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of sarcoidosis has not been reported. The purpose of the present study is to evaluate the diagnostic yield of EBUS-TBNA in demonstrating the pathological features of sarcoidosis. In total, 65 patients with suspected sarcoidosis, with enlarged hilar or mediastinal lymph nodes on computed tomography, were included in the study. Patients with a suspected or known malignancy or previously established diagnosis of sarcoidosis were excluded. Convex probe endobronchial ultrasonography integrated with a separate working channel was used for EBUS-TBNA. Surgical methods were performed in those in whom no granulomas were detected by EBUS-TBNA. Patients were followed up clinically. EBUS-TBNA was performed on a total of 77 lymph node stations in 65 patients. A final diagnosis of sarcoidosis was made for 61 (93.8%) of the patients. The remaining four patients were diagnosed as having Wegener's granulomatosis (n=1) or indefinite (n=3). In patients with a final diagnosis of sarcoidosis, EBUS-TBNA demonstrated noncaseating epithelioid cell granulomas in 56 (91.8%) of the patients. No complications were reported. Endobronchial ultrasound-guided transbronchial needle aspiration proved to be a safe procedure with a high yield for the diagnoses of sarcoidosis.-
dc.languageeng-
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com-
dc.relation.ispartofThe European Respiratory Journal-
dc.subject.meshBiopsy, Fine-Needle - methods-
dc.subject.meshBronchi - ultrasonography-
dc.subject.meshLymph Nodes - pathology-
dc.subject.meshLymphatic Diseases - pathology-
dc.subject.meshSarcoidosis - diagnosis - ultrasonography-
dc.titleEndobronchial ultrasound: new insight for the diagnosis of sarcoidosisen_US
dc.typeArticleen_US
dc.identifier.emailLam, WK: lamwk@hku.hk-
dc.identifier.emailFujisawa, T: fujisawat@faculty.chiba-u.jp-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1183/09031936.00028706-
dc.identifier.pmid17331972-
dc.identifier.hkuros134673-
dc.identifier.volume29-
dc.identifier.issue6-
dc.identifier.spage1182-
dc.identifier.epage1186-
dc.identifier.isiWOS:000247280500016-
dc.publisher.placeSwitzerland-

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