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Article: Dendritic Morphology of Caudal Periaqueductal Gray Projecting Retinal Ganglion Cells in Mongolian Gerbil (Meriones unguiculatus)

TitleDendritic Morphology of Caudal Periaqueductal Gray Projecting Retinal Ganglion Cells in Mongolian Gerbil (Meriones unguiculatus)
Authors
Issue Date2014
Citation
PLoS ONE, 2014, v. 9, article no. e103306 How to Cite?
AbstractIn this study we investigated the morphological features of the caudal periaqueductal gray (cPAG)-projecting retinal ganglion cells (RGCs) in Mongolian gerbils using retrograde labeling, in vitro intracellular injection, confocal microscopy and three-dimensional reconstruction approaches. cPAG-projecting RGCs exhibit small somata (10–17 µm) and irregular dendritic fields (201–298 µm). Sizes of somata and dendritic fields do not show obvious variation at different distance from the optic disk (eccentricity). Dendrites are moderately branched. Morphological analysis (n = 23) reveals that cPAG-projecting RGCs ramified in sublamina a and b in the inner plexiform layer. These cells exhibit different stratification patterns based on the thickness of dendritic bands in sublaminas a and b: majority of analyzed cells (16 out of 23) have two bands of arborizations share similar thickness. The rest of analyzed cells (7 out of 23) exhibit thinner band in sublamina a than in sublamina b. Together, the present study suggests that cPAG of Mongolian gerbil could receive direct retinal inputs from two types of bistratified RGCs. Furthermore, a small subset of melanopsin-expressing RGCs (total 41 in 6 animals) is shown to innervate the rostral PAG (rPAG). Functional characteristics of these non-visual center projecting RGCs remain to be determined.
Persistent Identifierhttp://hdl.handle.net/10722/205578
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSo, KFen_US
dc.contributor.authorPu, Men_US
dc.contributor.authorRen, Cen_US
dc.contributor.authorCui, Qen_US
dc.date.accessioned2014-09-20T04:00:23Z-
dc.date.available2014-09-20T04:00:23Z-
dc.date.issued2014en_US
dc.identifier.citationPLoS ONE, 2014, v. 9, article no. e103306en_US
dc.identifier.urihttp://hdl.handle.net/10722/205578-
dc.description.abstractIn this study we investigated the morphological features of the caudal periaqueductal gray (cPAG)-projecting retinal ganglion cells (RGCs) in Mongolian gerbils using retrograde labeling, in vitro intracellular injection, confocal microscopy and three-dimensional reconstruction approaches. cPAG-projecting RGCs exhibit small somata (10–17 µm) and irregular dendritic fields (201–298 µm). Sizes of somata and dendritic fields do not show obvious variation at different distance from the optic disk (eccentricity). Dendrites are moderately branched. Morphological analysis (n = 23) reveals that cPAG-projecting RGCs ramified in sublamina a and b in the inner plexiform layer. These cells exhibit different stratification patterns based on the thickness of dendritic bands in sublaminas a and b: majority of analyzed cells (16 out of 23) have two bands of arborizations share similar thickness. The rest of analyzed cells (7 out of 23) exhibit thinner band in sublamina a than in sublamina b. Together, the present study suggests that cPAG of Mongolian gerbil could receive direct retinal inputs from two types of bistratified RGCs. Furthermore, a small subset of melanopsin-expressing RGCs (total 41 in 6 animals) is shown to innervate the rostral PAG (rPAG). Functional characteristics of these non-visual center projecting RGCs remain to be determined.en_US
dc.languageengen_US
dc.relation.ispartofPLoS ONEen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleDendritic Morphology of Caudal Periaqueductal Gray Projecting Retinal Ganglion Cells in Mongolian Gerbil (Meriones unguiculatus)en_US
dc.typeArticleen_US
dc.identifier.emailSo, KF: hrmaskf@hku.hken_US
dc.identifier.emailPu, M: vl1018@hku.hken_US
dc.identifier.emailRen, C: tchaoran@jnu.edu.cnen_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0103306en_US
dc.identifier.pmid25054882-
dc.identifier.hkuros239446en_US
dc.identifier.volume9en_US
dc.identifier.spagearticle no. e103306en_US
dc.identifier.epagearticle no. e103306en_US
dc.identifier.isiWOS:000339614100106-

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