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Article: Dynamic development of regional cortical thickness and surface area in early childhood

TitleDynamic development of regional cortical thickness and surface area in early childhood
Authors
Issue Date2014
Citation
Cerebral Cortex (In press), 2014 How to Cite?
AbstractCortical thickness (CT) and surface area (SA) are altered in many neuropsychiatric disorders and are correlated with cognitive func- tioning. Little is known about how these components of cortical gray matter develop in the first years of life. We studied the longitudinal development of regional CT and SA expansion in healthy infants from birth to 2 years. CT and SA have distinct and heterogeneous patterns of development that are exceptionally dynamic; overall CT increases by an average of 36.1%, while cortical SA increases 114.6%. By age 2, CT is on average 97% of adult values, compared with SA, which is 69%. This suggests that early identification, prevention, and interven- tion strategies for neuropsychiatric illness need to be targeted to this period of rapid postnatal brain development, and that SA expansion is the principal driving factor in cortical volume after 2 years of age.
Persistent Identifierhttp://hdl.handle.net/10722/204956

 

DC FieldValueLanguage
dc.contributor.authorLyall, AEen_US
dc.contributor.authorShi, Fen_US
dc.contributor.authorGeng, Xen_US
dc.contributor.authorWoolson, Sen_US
dc.contributor.authorLi, Gen_US
dc.contributor.authorWang, Len_US
dc.contributor.authorHamer, RMen_US
dc.contributor.authorShen, Den_US
dc.contributor.authorGilmore, JHen_US
dc.date.accessioned2014-09-20T01:14:17Z-
dc.date.available2014-09-20T01:14:17Z-
dc.date.issued2014-
dc.identifier.citationCerebral Cortex (In press), 2014en_US
dc.identifier.urihttp://hdl.handle.net/10722/204956-
dc.description.abstractCortical thickness (CT) and surface area (SA) are altered in many neuropsychiatric disorders and are correlated with cognitive func- tioning. Little is known about how these components of cortical gray matter develop in the first years of life. We studied the longitudinal development of regional CT and SA expansion in healthy infants from birth to 2 years. CT and SA have distinct and heterogeneous patterns of development that are exceptionally dynamic; overall CT increases by an average of 36.1%, while cortical SA increases 114.6%. By age 2, CT is on average 97% of adult values, compared with SA, which is 69%. This suggests that early identification, prevention, and interven- tion strategies for neuropsychiatric illness need to be targeted to this period of rapid postnatal brain development, and that SA expansion is the principal driving factor in cortical volume after 2 years of age.en_US
dc.languageengen_US
dc.relation.ispartofCerebral Cortexen_US
dc.titleDynamic development of regional cortical thickness and surface area in early childhooden_US
dc.typeArticleen_US
dc.identifier.emailGeng, X: gengx@hku.hken_US
dc.identifier.authorityGeng, X=rp01678en_US
dc.identifier.doi10.1093/cercor/bhu027-
dc.identifier.hkuros239144en_US

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