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Article: Neurokinin B and reproductive functions: 'KNDy neuron' model in mammals and the emerging story in fish

TitleNeurokinin B and reproductive functions: 'KNDy neuron' model in mammals and the emerging story in fish
Authors
Issue Date2014
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcen
Citation
General and Comparative Endocrinology, 2014, v. 208, p. 94-108 How to Cite?
AbstractIn mammals, neurokinin B (NKB), the gene product of the tachykinin family member TAC3, is known to be a key regulator for episodic release of luteinizing hormone (LH). Its regulatory actions are mediated by a subpopulation of kisspeptin neurons within the arcuate nucleus with co-expression of NKB and dynorphin A (commonly called the 'KNDy neurons'). By forming an 'autosynaptic feedback loop' within the hypothalamus, the KNDy neurons can modulate gonadotropin-releasing hormone (GnRH) pulsatility and subsequent LH release in the pituitary. NKB regulation of LH secretion has been recently demonstrated in zebrafish, suggesting that the reproductive functions of NKB may be conserved from fish to mammals. Interestingly, the TAC3 genes in fish not only encode the mature peptide of NKB but also a novel tachykinin-like peptide, namely NKB-related peptide (or neurokinin F). Recent studies in zebrafish also reveal that the neuroanatomy of TAC3/kisspeptin system within the fish brain is quite different from that of mammals. In this article, the current ideas of 'KNDy neuron' model for GnRH regulation and steroid feedback, other reproductive functions of NKB including its local actions in the gonad and placenta, the revised model of tachykinin evolution from invertebrates to vertebrates, as well as the emerging story of the two TAC3 gene products in fish, NKB and NKB-related peptide, will be reviewed with stress on the areas with interesting questions for future investigations.
Persistent Identifierhttp://hdl.handle.net/10722/204823
ISSN
2015 Impact Factor: 2.667
2015 SCImago Journal Rankings: 1.245

 

DC FieldValueLanguage
dc.contributor.authorHu, G-
dc.contributor.authorLin, C-
dc.contributor.authorHe, M-
dc.contributor.authorWong, AOL-
dc.date.accessioned2014-09-20T00:42:47Z-
dc.date.available2014-09-20T00:42:47Z-
dc.date.issued2014-
dc.identifier.citationGeneral and Comparative Endocrinology, 2014, v. 208, p. 94-108-
dc.identifier.issn0016-6480-
dc.identifier.urihttp://hdl.handle.net/10722/204823-
dc.description.abstractIn mammals, neurokinin B (NKB), the gene product of the tachykinin family member TAC3, is known to be a key regulator for episodic release of luteinizing hormone (LH). Its regulatory actions are mediated by a subpopulation of kisspeptin neurons within the arcuate nucleus with co-expression of NKB and dynorphin A (commonly called the 'KNDy neurons'). By forming an 'autosynaptic feedback loop' within the hypothalamus, the KNDy neurons can modulate gonadotropin-releasing hormone (GnRH) pulsatility and subsequent LH release in the pituitary. NKB regulation of LH secretion has been recently demonstrated in zebrafish, suggesting that the reproductive functions of NKB may be conserved from fish to mammals. Interestingly, the TAC3 genes in fish not only encode the mature peptide of NKB but also a novel tachykinin-like peptide, namely NKB-related peptide (or neurokinin F). Recent studies in zebrafish also reveal that the neuroanatomy of TAC3/kisspeptin system within the fish brain is quite different from that of mammals. In this article, the current ideas of 'KNDy neuron' model for GnRH regulation and steroid feedback, other reproductive functions of NKB including its local actions in the gonad and placenta, the revised model of tachykinin evolution from invertebrates to vertebrates, as well as the emerging story of the two TAC3 gene products in fish, NKB and NKB-related peptide, will be reviewed with stress on the areas with interesting questions for future investigations.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcen-
dc.relation.ispartofGeneral and Comparative Endocrinology-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in General and Comparative Endocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in General and Comparative Endocrinology, 2014, v. 208, p. 94-108. DOI: 10.1016/j.ygcen.2014.08.009-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleNeurokinin B and reproductive functions: 'KNDy neuron' model in mammals and the emerging story in fish-
dc.typeArticle-
dc.identifier.emailHe, M: hemu@hkucc.hku.hk-
dc.identifier.emailWong, AOL: olwong@hkucc.hku.hk-
dc.identifier.authorityWong, AOL=rp00806-
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.ygcen.2014.08.009-
dc.identifier.pmid25172151-
dc.identifier.hkuros239528-
dc.identifier.hkuros253664-
dc.identifier.volume208-
dc.identifier.spage94-
dc.identifier.epage108-
dc.publisher.placeUnited States-

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