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Conference Paper: Dexmedetomidine reduced astrocyte connexin 43 and attenuated neuropathic pain induced by partial sciatic nerve ligation in rats

TitleDexmedetomidine reduced astrocyte connexin 43 and attenuated neuropathic pain induced by partial sciatic nerve ligation in rats
Authors
Issue Date2014
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
The 2014 Annual Meeting of Experimental Biology (EB 2014), San Diego, CA., 26-30 April 2014. In The FASEB Journal, 2014, v. 28 suppl. 1, abstract no. LB503 How to Cite?
AbstractDexmedetomidine(DEX) has been shown to attenuate neuropathic pain (NP), but the mechanism is unclear. Astrocytes connexin 43(Cx43) is increased in subjects with NP and plays an important role in the development and maintenance of NP (Glia. 2012;60(11):1660-70). We thus investigated the role of astroglia Cx43 in DEX-induced anti-nociceptive effects in rats with NP. Peripheral NP was induced by partial sciatic nerve ligation (PSNL) in SD rats. After 10 days of inducing NP, DEX was intrathecally administrated for 5 days and ipsilateral mechanical allodynia and thermal hyperalgesia were examined by Von Frey Test and Hargreaves Test. Compared with control rats, PSNL induced significant ipsilateral mechanical allodynia and thermal hyperalgesia (P<0.05) that were coincident with enhanced Cx43 and increased astroglia activation in ipsilateral lumbosacral dorsal spinal cord. DEX inhibited astroglia Cx43 expression and attenuated NP (P<0.05 vs. control). Cx43 gene knock-down did not significantly further enhance DEX mediated attenuation of NP. We concluded that astroglia Cx43 plays a critical role in DEX mediated anti-nociceptive effects in rats with NP.
DescriptionConference Theme: Transforming the Future through Science
Session: Pathology - Mechanisms and Models of Neurological Diseases
Persistent Identifierhttp://hdl.handle.net/10722/204769
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorWang, Len_US
dc.contributor.authorHuang, Hen_US
dc.contributor.authorXia, W-
dc.contributor.authorHe, Y-
dc.contributor.authorCheung, CW-
dc.contributor.authorXia, Z-
dc.date.accessioned2014-09-20T00:39:20Z-
dc.date.available2014-09-20T00:39:20Z-
dc.date.issued2014en_US
dc.identifier.citationThe 2014 Annual Meeting of Experimental Biology (EB 2014), San Diego, CA., 26-30 April 2014. In The FASEB Journal, 2014, v. 28 suppl. 1, abstract no. LB503en_US
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/204769-
dc.descriptionConference Theme: Transforming the Future through Science-
dc.descriptionSession: Pathology - Mechanisms and Models of Neurological Diseases-
dc.description.abstractDexmedetomidine(DEX) has been shown to attenuate neuropathic pain (NP), but the mechanism is unclear. Astrocytes connexin 43(Cx43) is increased in subjects with NP and plays an important role in the development and maintenance of NP (Glia. 2012;60(11):1660-70). We thus investigated the role of astroglia Cx43 in DEX-induced anti-nociceptive effects in rats with NP. Peripheral NP was induced by partial sciatic nerve ligation (PSNL) in SD rats. After 10 days of inducing NP, DEX was intrathecally administrated for 5 days and ipsilateral mechanical allodynia and thermal hyperalgesia were examined by Von Frey Test and Hargreaves Test. Compared with control rats, PSNL induced significant ipsilateral mechanical allodynia and thermal hyperalgesia (P<0.05) that were coincident with enhanced Cx43 and increased astroglia activation in ipsilateral lumbosacral dorsal spinal cord. DEX inhibited astroglia Cx43 expression and attenuated NP (P<0.05 vs. control). Cx43 gene knock-down did not significantly further enhance DEX mediated attenuation of NP. We concluded that astroglia Cx43 plays a critical role in DEX mediated anti-nociceptive effects in rats with NP.-
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/-
dc.relation.ispartofThe FASEB Journalen_US
dc.titleDexmedetomidine reduced astrocyte connexin 43 and attenuated neuropathic pain induced by partial sciatic nerve ligation in ratsen_US
dc.typeConference_Paperen_US
dc.identifier.emailCheung, CW: cheucw@hku.hken_US
dc.identifier.emailXia, Z: zyxia@hkucc.hku.hken_US
dc.identifier.authorityCheung, CW=rp00244en_US
dc.identifier.authorityXia, Z=rp00532en_US
dc.identifier.hkuros235647en_US
dc.identifier.volume28en_US
dc.identifier.issuesuppl. 1en_US
dc.publisher.placeUnited States-

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