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Conference Paper: The roles of IP10 in liver regeneration and tissue repair are cell type dependent

TitleThe roles of IP10 in liver regeneration and tissue repair are cell type dependent
Authors
KeywordsMedical sciences
Gastroenterology medical sciences
Surgery
Issue Date2014
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
The 2014 Joint International Congress of ILTS, ELITA and LICAGE, London, UK., 4-7 June 2014. In Liver Transplantation, 2014, v. 20 suppl. S1, p. S309, abstract P-507 How to Cite?
AbstractINTRODUCTION AND AIM: Impairment of liver regeneration is the major consequence resulted from acute phase marginal liver graft injury. Understanding of key players in liver regeneration is crucial to develop potential treatments such as stem cell therapy. IFN-inducible protein 10 (IP10) was reported to have controversial roles in liver regeneration. Here, we aimed to investigate the role of IP10 in marginal graft regeneration, and to explore its effect on bone marrow derived mesenchymal stem cells (BM-MSC) proliferation. METHODS: The expression of hepatic IP10 and hepatocyte proliferation was assessed at day 2, 4 and 7 post-transplantation in a rat orthotopic liver transplantation model using normal or fatty small-for-size grafts. To investigate the role of IP10 in hepatocyte proliferation and liver regeneration, IP10-/- and CXCR3-/- (IP10 receptor) mice with or without fatty liver were subjected to major hepatectomy and partial hepatic ischemia/reperfusion injury. Mice hepatocyte proliferation, expressions of HGF and vascular endothelial growth factor were compared among the different groups. To explore the role of IP10 on BM-MSC, we compared cell proliferation, differentiation and cell cycle of the BM-MSCs from IP10-/-, CXCR3-/- and wild type mice. RESULTS: Intrahepatic IP10 expression was signifi cantly reduced in small-for-size fatty graft in comparison to normal graft (day 2: 2.48 vs 8.22 folds, p < 0.05) and correlated with lower hepatocyte proliferation (day 2: 6.5/HPF vs 32/HPF, p < 0.01) after transplantation. Signifi cant impairment in hepatocyte proliferation in IP10-/-and CXCR3-/- mice was also detected.
DescriptionPoster Session 3: P-507
This journal suppl. entitled: The ILTS 20th Annual International Congress
Persistent Identifierhttp://hdl.handle.net/10722/204488
ISSN
2015 Impact Factor: 3.951
2015 SCImago Journal Rankings: 1.763

 

DC FieldValueLanguage
dc.contributor.authorMa, YY-
dc.contributor.authorLi, C-
dc.contributor.authorGeng, W-
dc.contributor.authorNg, KTP-
dc.contributor.authorLo, CM-
dc.contributor.authorMan, K-
dc.date.accessioned2014-09-19T23:57:02Z-
dc.date.available2014-09-19T23:57:02Z-
dc.date.issued2014-
dc.identifier.citationThe 2014 Joint International Congress of ILTS, ELITA and LICAGE, London, UK., 4-7 June 2014. In Liver Transplantation, 2014, v. 20 suppl. S1, p. S309, abstract P-507-
dc.identifier.issn1527-6465-
dc.identifier.urihttp://hdl.handle.net/10722/204488-
dc.descriptionPoster Session 3: P-507-
dc.descriptionThis journal suppl. entitled: The ILTS 20th Annual International Congress-
dc.description.abstractINTRODUCTION AND AIM: Impairment of liver regeneration is the major consequence resulted from acute phase marginal liver graft injury. Understanding of key players in liver regeneration is crucial to develop potential treatments such as stem cell therapy. IFN-inducible protein 10 (IP10) was reported to have controversial roles in liver regeneration. Here, we aimed to investigate the role of IP10 in marginal graft regeneration, and to explore its effect on bone marrow derived mesenchymal stem cells (BM-MSC) proliferation. METHODS: The expression of hepatic IP10 and hepatocyte proliferation was assessed at day 2, 4 and 7 post-transplantation in a rat orthotopic liver transplantation model using normal or fatty small-for-size grafts. To investigate the role of IP10 in hepatocyte proliferation and liver regeneration, IP10-/- and CXCR3-/- (IP10 receptor) mice with or without fatty liver were subjected to major hepatectomy and partial hepatic ischemia/reperfusion injury. Mice hepatocyte proliferation, expressions of HGF and vascular endothelial growth factor were compared among the different groups. To explore the role of IP10 on BM-MSC, we compared cell proliferation, differentiation and cell cycle of the BM-MSCs from IP10-/-, CXCR3-/- and wild type mice. RESULTS: Intrahepatic IP10 expression was signifi cantly reduced in small-for-size fatty graft in comparison to normal graft (day 2: 2.48 vs 8.22 folds, p < 0.05) and correlated with lower hepatocyte proliferation (day 2: 6.5/HPF vs 32/HPF, p < 0.01) after transplantation. Signifi cant impairment in hepatocyte proliferation in IP10-/-and CXCR3-/- mice was also detected.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021-
dc.relation.ispartofLiver Transplantation-
dc.rightsLiver Transplantation. Copyright © John Wiley & Sons, Inc.-
dc.subjectMedical sciences-
dc.subjectGastroenterology medical sciences-
dc.subjectSurgery-
dc.titleThe roles of IP10 in liver regeneration and tissue repair are cell type dependent-
dc.typeConference_Paper-
dc.identifier.emailMa, YY: yyma@hku.hk-
dc.identifier.emailLi, C: doclicx@hku.hk-
dc.identifier.emailGeng, W: weigeng@hku.hk-
dc.identifier.emailNg, KTP: ledodes@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailMan, K: kwanman@hku.hk-
dc.identifier.authorityNg, KTP=rp01720-
dc.identifier.authorityLo, CM=rp00412-
dc.identifier.authorityMan, K=rp00417-
dc.identifier.doi10.1002/lt.23901-
dc.identifier.hkuros237553-
dc.identifier.volume20-
dc.identifier.issuesuppl. S1-
dc.identifier.spageS309, abstract P-507-
dc.identifier.epageS309, abstract P-507-
dc.publisher.placeUnited States-

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