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Conference Paper: Central nervous system tumors in Chinese children under the age of three: a population study by the Hong Kong Paediatric Haematology/Oncology Study Group

TitleCentral nervous system tumors in Chinese children under the age of three: a population study by the Hong Kong Paediatric Haematology/Oncology Study Group
Authors
KeywordsMedical sciences
Oncology
Issue Date2014
PublisherOxford University Press. The Journal's web site is located at http://neuro-oncology.dukejournals.org
Citation
The 16th International Symposium on Pediatric Neuro-Oncology (ISPNO 2014), Singapore, 28 June-2 July 2014. In Neuro-Oncology, 2014, v. 16 suppl. 1, p. i26-i29, no. EP-001 How to Cite?
AbstractThe management of CNS tumors in children below the age of three represents special challenge to pediatric oncologists with distinctive epidemiology, treatment considerations and prognosis. Population-based epidemiological data on this particular patient group is lacking in Chinese. We reviewed the population-based pediatric tumor registry of the Hong Kong Paediatric Haematology/Oncology Study Group between 1999 and 2011. Eighty-one children with primary CNS tumors from 0-3 years were identified (annual incidence: 4.16 cases per 100,000). Forty-one (50.6%) were male and mean duration of FU was 94 months (±8.1). Primary tumors were infratentorial in 43 (53.1%). The tumor types in decreasing frequency were astrocytoma (n = 17), medulloblastoma (n = 16), ependymoma (n = 13), CPT (n = 7), PNET (n = 7), ATRT (n = 6), GCT (n = 5), craniopharyngioma (n = 4) and ganglioglioma (n = 3). Three patients presented antenatally. Treatment included surgery in 82.7%, chemotherapy in 50.6% and radiotherapy in 25.9%. There were 29 deaths (35.8%) and 19 relapses (23.5%) during the review period with the 1y-OS, 5y-OS, 1y-EFS and 5y-EFS being 79.4% (±4.6), 63.5% (±5.9), 68.9% (±5.3) and 52.5% (±5.9) respectively. Significantly better OS and EFS were observed in patients who received gross-total resection but those with high-grade tumors, antenatal diagnosis or ATRT/PNET had worse outcome. Survival did not differ with age. Comparison with statistics from other studies revealed higher rates of embryonal tumor, GCT and craniopharyngioma in Hong Kong Chinese. Disease outcome appeared to be better in our cohort comparing to previous reports probably due to the higher proportion of GCT locally.
DescriptionSession - Epidemiology: no. EP-001
This journal suppl. entitled: Abstracts from the 16th International Symposium on Pediatric Neuro-Oncology in conjunction with the 8th St. Jude-VIVA Forum ... 2014
Persistent Identifierhttp://hdl.handle.net/10722/204437
ISSN
2015 Impact Factor: 7.371
2015 SCImago Journal Rankings: 3.196

 

DC FieldValueLanguage
dc.contributor.authorLiu, APYen_US
dc.contributor.authorShing, MMKen_US
dc.contributor.authorYuen, HLen_US
dc.contributor.authorLi, CHen_US
dc.contributor.authorLing, SCen_US
dc.contributor.authorLuk, CWen_US
dc.contributor.authorHa, SYen_US
dc.contributor.authorLi, CKen_US
dc.contributor.authorChan, GCFen_US
dc.date.accessioned2014-09-19T23:48:14Z-
dc.date.available2014-09-19T23:48:14Z-
dc.date.issued2014en_US
dc.identifier.citationThe 16th International Symposium on Pediatric Neuro-Oncology (ISPNO 2014), Singapore, 28 June-2 July 2014. In Neuro-Oncology, 2014, v. 16 suppl. 1, p. i26-i29, no. EP-001en_US
dc.identifier.issn1522-8517-
dc.identifier.urihttp://hdl.handle.net/10722/204437-
dc.descriptionSession - Epidemiology: no. EP-001-
dc.descriptionThis journal suppl. entitled: Abstracts from the 16th International Symposium on Pediatric Neuro-Oncology in conjunction with the 8th St. Jude-VIVA Forum ... 2014-
dc.description.abstractThe management of CNS tumors in children below the age of three represents special challenge to pediatric oncologists with distinctive epidemiology, treatment considerations and prognosis. Population-based epidemiological data on this particular patient group is lacking in Chinese. We reviewed the population-based pediatric tumor registry of the Hong Kong Paediatric Haematology/Oncology Study Group between 1999 and 2011. Eighty-one children with primary CNS tumors from 0-3 years were identified (annual incidence: 4.16 cases per 100,000). Forty-one (50.6%) were male and mean duration of FU was 94 months (±8.1). Primary tumors were infratentorial in 43 (53.1%). The tumor types in decreasing frequency were astrocytoma (n = 17), medulloblastoma (n = 16), ependymoma (n = 13), CPT (n = 7), PNET (n = 7), ATRT (n = 6), GCT (n = 5), craniopharyngioma (n = 4) and ganglioglioma (n = 3). Three patients presented antenatally. Treatment included surgery in 82.7%, chemotherapy in 50.6% and radiotherapy in 25.9%. There were 29 deaths (35.8%) and 19 relapses (23.5%) during the review period with the 1y-OS, 5y-OS, 1y-EFS and 5y-EFS being 79.4% (±4.6), 63.5% (±5.9), 68.9% (±5.3) and 52.5% (±5.9) respectively. Significantly better OS and EFS were observed in patients who received gross-total resection but those with high-grade tumors, antenatal diagnosis or ATRT/PNET had worse outcome. Survival did not differ with age. Comparison with statistics from other studies revealed higher rates of embryonal tumor, GCT and craniopharyngioma in Hong Kong Chinese. Disease outcome appeared to be better in our cohort comparing to previous reports probably due to the higher proportion of GCT locally.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://neuro-oncology.dukejournals.org-
dc.relation.ispartofNeuro-Oncologyen_US
dc.subjectMedical sciences-
dc.subjectOncology-
dc.titleCentral nervous system tumors in Chinese children under the age of three: a population study by the Hong Kong Paediatric Haematology/Oncology Study Groupen_US
dc.typeConference_Paperen_US
dc.identifier.emailLiu, APY: apyliu@hku.hken_US
dc.identifier.emailHa, SY: syha@hku.hken_US
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.authorityLiu, APY=rp01357en_US
dc.identifier.authorityChan, GCF=rp00431en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/neuonc/nou069-
dc.identifier.hkuros240001en_US
dc.identifier.volume16-
dc.identifier.issuesuppl. 1-
dc.identifier.spagei26-
dc.identifier.epagei29-
dc.publisher.placeUnited States-

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