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Conference Paper: Use of strontium-enriched bioactive bone cement in enhancing tendon osteointegration in a rabbit anterior cruciate ligament reconstruction model

TitleUse of strontium-enriched bioactive bone cement in enhancing tendon osteointegration in a rabbit anterior cruciate ligament reconstruction model
Authors
Issue Date2013
Citation
The 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA), Hong Kong, 23-24 November 2013. In Conference Abstracts, 2013, p. 50, abstract no. 5.17 How to Cite?
AbstractIntroduction: It was hypothesised that strontium led to accelerated healing of strontium-enriched calcium phosphate cement (Sr-CPC)–treated soft tissue tendon graft within the bone tunnel in anterior cruciate ligament (ACL) reconstruction. This hypothesis was tested in a rabbit ACL reconstruction model using Achilles tendon allograft. Methods: A total of 30 bilateral ACL reconstructions were performed in 15 rabbits. The graft on the tested limb was treated with Sr-CPC, while that on the contralateral limb was treated with CPC. Three were sacrificed for histomorphometric analysis respectively at 3, 6, 9, 12, and 24 weeks after the index operation. Histomorphometric analysis of the healing of graft was done by 2 independent observers in 42 histological zones per animal using a scoring system of 0 to 9. The data were analysed by Mann-Whitney U test. Results: Accelerated healing of the graft within bone tunnel was noted in the strontium-treated limb at 3, 6, 9, and 12 weeks after the operation (p < 0.001) when compared with the CPC-treated limb. Complete healing of the graft by Sharpey’s fibre formation at 9 weeks and early evidence of remodelling into normal ACL insertion site at 12 weeks were noted in the SrCPC group. The healing of the graft in the CPC-treated limb was noted 3 to 6 weeks slower than the Sr-CPC group. Conclusion: Strontium is the main contributing factor leading to accelerated healing of Sr-CPC–treated soft tissue tendon graft in a rabbit ACL reconstruction model.
DescriptionConference Theme: Defying the Aging Spine: Our Mission Continues
Concurrent Free Papers 5 - Sports: no. 5.17
Persistent Identifierhttp://hdl.handle.net/10722/204345

 

DC FieldValueLanguage
dc.contributor.authorYau, WPen_US
dc.contributor.authorKuang, Gen_US
dc.contributor.authorLu, WWen_US
dc.contributor.authorChiu, KYen_US
dc.date.accessioned2014-09-19T22:41:16Z-
dc.date.available2014-09-19T22:41:16Z-
dc.date.issued2013en_US
dc.identifier.citationThe 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA), Hong Kong, 23-24 November 2013. In Conference Abstracts, 2013, p. 50, abstract no. 5.17en_US
dc.identifier.urihttp://hdl.handle.net/10722/204345-
dc.descriptionConference Theme: Defying the Aging Spine: Our Mission Continues-
dc.descriptionConcurrent Free Papers 5 - Sports: no. 5.17-
dc.description.abstractIntroduction: It was hypothesised that strontium led to accelerated healing of strontium-enriched calcium phosphate cement (Sr-CPC)–treated soft tissue tendon graft within the bone tunnel in anterior cruciate ligament (ACL) reconstruction. This hypothesis was tested in a rabbit ACL reconstruction model using Achilles tendon allograft. Methods: A total of 30 bilateral ACL reconstructions were performed in 15 rabbits. The graft on the tested limb was treated with Sr-CPC, while that on the contralateral limb was treated with CPC. Three were sacrificed for histomorphometric analysis respectively at 3, 6, 9, 12, and 24 weeks after the index operation. Histomorphometric analysis of the healing of graft was done by 2 independent observers in 42 histological zones per animal using a scoring system of 0 to 9. The data were analysed by Mann-Whitney U test. Results: Accelerated healing of the graft within bone tunnel was noted in the strontium-treated limb at 3, 6, 9, and 12 weeks after the operation (p < 0.001) when compared with the CPC-treated limb. Complete healing of the graft by Sharpey’s fibre formation at 9 weeks and early evidence of remodelling into normal ACL insertion site at 12 weeks were noted in the SrCPC group. The healing of the graft in the CPC-treated limb was noted 3 to 6 weeks slower than the Sr-CPC group. Conclusion: Strontium is the main contributing factor leading to accelerated healing of Sr-CPC–treated soft tissue tendon graft in a rabbit ACL reconstruction model.-
dc.languageengen_US
dc.relation.ispartof33rd HKOA Annual Congress 2013en_US
dc.relation.ispartof2013 香港骨科醫學會第三十三屇週年會議-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleUse of strontium-enriched bioactive bone cement in enhancing tendon osteointegration in a rabbit anterior cruciate ligament reconstruction modelen_US
dc.typeConference_Paperen_US
dc.identifier.emailYau, WP: peterwpy@hkucc.hku.hken_US
dc.identifier.emailKuang, G: kuanggm@connect.hku.hken_US
dc.identifier.emailLu, WW: wwlu@hku.hken_US
dc.identifier.emailChiu, KY: pkychiu@hkucc.hku.hken_US
dc.identifier.authorityYau, WP=rp00500en_US
dc.identifier.authorityLu, WW=rp00411en_US
dc.identifier.authorityChiu, KY=rp00379en_US
dc.description.naturepostprint-
dc.identifier.hkuros236666en_US
dc.identifier.hkuros240336-
dc.identifier.spage50, abstract no. 5.17-
dc.identifier.epage50, abstract no. 5.17-

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