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Conference Paper: Microstructural Transition and Mechanical Incompetence of Trabecular Bone around Subchondral Cyst in Knee Osteoarthritis

TitleMicrostructural Transition and Mechanical Incompetence of Trabecular Bone around Subchondral Cyst in Knee Osteoarthritis
Authors
Issue Date2013
PublisherHong Kong Academy of Medicine Press.
Citation
The 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA), Hong Kong, China, 23-24 November 2013. In the Abstracts of the 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA), 2013, p. 39, abstract no. 4.11 How to Cite?
AbstractIntroduction: Subchondral bone cysts (SBCs) were associated with greater loss of articular cartilage and increased risk of joint replacement. This study aimed to characterise subchondral bone disturbance with SBC formation in knee osteoarthritis (OA). Materials and Methods: Tibial specimens were collected during surgeries for a total of 70 patients (age range, 52-86 years) with late-stage knee OA. The specimens were then divided into the SBC+ and SBC- groups according to the presence or absence of SBCs under microcomputed tomographic evaluations. They were processed for the compressive mechanical testing and nanoindentation sequentially. Comparisons of microstructural and mechanical properties of trabecular bone were performed between 2 groups using Student’s t test. Results: The SBCs were present in the majority of tibial specimens (55/70, 78.5%). Their diameter ranged from 1.5 to 14 mm. A greater increase in mean (± standard deviation) trabecular bone volume fraction (BV/TV) was found in OA specimens with SBC+ group (24 ± 9%) compared with SBC- group (18 ± 5%, p = 0.035). It was prominent when the SBC was < 5 mm. The mean compressive modulus of trabecular bone of SBC+ group (47 ± 23 MPa) did not statistically differ from SBC- group (53 ± 33 MPa, p = 0.646) although the former presented higher BV/TV. The mean nano-stiffness of trabeculae in SBC+ group (7.73 ± 1.29 GPa) was significantly lower than SBC-group (12.03 ± 1.98 MPa, p < 0.001). Discussion and Conclusion: The presence of SBC could be an indicator for the poor quality of subchondral bone in the pathophysiology of knee OA.
DescriptionConference Theme: Defying the Aging Spine
Concurrent Free Papers 4: Hips and Knees I
Persistent Identifierhttp://hdl.handle.net/10722/204332

 

DC FieldValueLanguage
dc.contributor.authorWen, Cen_US
dc.contributor.authorYan, CHen_US
dc.contributor.authorLu, WWen_US
dc.contributor.authorChiu, PKYen_US
dc.date.accessioned2014-09-19T22:41:15Z-
dc.date.available2014-09-19T22:41:15Z-
dc.date.issued2013en_US
dc.identifier.citationThe 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA), Hong Kong, China, 23-24 November 2013. In the Abstracts of the 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA), 2013, p. 39, abstract no. 4.11en_US
dc.identifier.urihttp://hdl.handle.net/10722/204332-
dc.descriptionConference Theme: Defying the Aging Spine-
dc.descriptionConcurrent Free Papers 4: Hips and Knees I-
dc.description.abstractIntroduction: Subchondral bone cysts (SBCs) were associated with greater loss of articular cartilage and increased risk of joint replacement. This study aimed to characterise subchondral bone disturbance with SBC formation in knee osteoarthritis (OA). Materials and Methods: Tibial specimens were collected during surgeries for a total of 70 patients (age range, 52-86 years) with late-stage knee OA. The specimens were then divided into the SBC+ and SBC- groups according to the presence or absence of SBCs under microcomputed tomographic evaluations. They were processed for the compressive mechanical testing and nanoindentation sequentially. Comparisons of microstructural and mechanical properties of trabecular bone were performed between 2 groups using Student’s t test. Results: The SBCs were present in the majority of tibial specimens (55/70, 78.5%). Their diameter ranged from 1.5 to 14 mm. A greater increase in mean (± standard deviation) trabecular bone volume fraction (BV/TV) was found in OA specimens with SBC+ group (24 ± 9%) compared with SBC- group (18 ± 5%, p = 0.035). It was prominent when the SBC was < 5 mm. The mean compressive modulus of trabecular bone of SBC+ group (47 ± 23 MPa) did not statistically differ from SBC- group (53 ± 33 MPa, p = 0.646) although the former presented higher BV/TV. The mean nano-stiffness of trabeculae in SBC+ group (7.73 ± 1.29 GPa) was significantly lower than SBC-group (12.03 ± 1.98 MPa, p < 0.001). Discussion and Conclusion: The presence of SBC could be an indicator for the poor quality of subchondral bone in the pathophysiology of knee OA.-
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press.-
dc.relation.ispartofAnnual Congress of the Hong Kong Orthopaedic Association (HKOA)en_US
dc.rightsAnnual Congress of the Hong Kong Orthopaedic Association (HKOA). Copyright © Hong Kong Academy of Medicine Press.-
dc.titleMicrostructural Transition and Mechanical Incompetence of Trabecular Bone around Subchondral Cyst in Knee Osteoarthritisen_US
dc.typeConference_Paperen_US
dc.identifier.emailWen, C: paulwen@hku.hken_US
dc.identifier.emailYan, CH: yanchoi@hku.hken_US
dc.identifier.emailLu, WW: wwlu@hku.hken_US
dc.identifier.emailChiu, PKY: pkychiu@hkucc.hku.hken_US
dc.identifier.authorityYan, CH=rp00303en_US
dc.identifier.authorityLu, WW=rp00411en_US
dc.identifier.authorityChiu, PKY=rp00379en_US
dc.identifier.hkuros235775en_US
dc.identifier.hkuros240334-
dc.identifier.spage39, abstract no. 4.11en_US
dc.identifier.epage39, abstract no. 4.11en_US
dc.publisher.placeHong Kong, China-

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